Optimizing smartphone psychotherapy for depressive symptoms in patients with cancer: Multiphase optimization strategy using a decentralized multicenter randomized clinical trial (J‐SUPPORT 2001 Study)
Aim Patients with cancer experience various forms of psychological distress, including depressive symptoms, which can impact quality of life, elevate morbidity risk, and increase medical costs. Psychotherapy and pharmacotherapy are effective for reducing depressive symptoms among patients with cance...
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| Veröffentlicht in: | Psychiatry and clinical neurosciences 2024-06, Vol.78 (6), p.353-361 |
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| creator | Akechi, Tatsuo Furukawa, Toshiaki A. Noma, Hisashi Iwata, Hiroji Toyama, Tatsuya Higaki, Kenji Matsuoka, Hiromichi Zenda, Sadamoto Iwatani, Tsuguo Akahane, Kazuhisa Inoue, Akira Sagara, Yasuaki Uchida, Megumi Imai, Fuminobu Momino, Kanae Imaizumi, Gen Yamaguchi, Takuhiro Mashiko, Tomoe Miyaji, Tempei Horikoshi, Masaru Sakurai, Naomi Onishi, Tatsuya Kanemitsu, Yukihide Murata, Takeshi Wanifuchi‐Endo, Yumi Kuroda, Hiroaki Nishikawa, Ryutaro Miyashita, Minoru Abe, Masakazu Uchitomi, Yosuke |
| description | Aim
Patients with cancer experience various forms of psychological distress, including depressive symptoms, which can impact quality of life, elevate morbidity risk, and increase medical costs. Psychotherapy and pharmacotherapy are effective for reducing depressive symptoms among patients with cancer, but most patients prefer psychotherapy. This study aimed to develop an efficient and effective smartphone psychotherapy component to address depressive symptom.
Methods
This was a decentralized, parallel‐group, multicenter, open, individually randomized, fully factorial trial. Patients aged ≥20 years with cancer were randomized by the presence/absence of three cognitive‐behavioral therapy (CBT) skills (behavioral activation [BA], assertiveness training [AT], and problem‐solving [PS]) on a smartphone app. All participants received psychoeducation (PE). The primary outcome was change in the patient health questionnaire‐9 (PHQ‐9) total score between baseline and week 8. Secondary outcomes included anxiety.
Results
In total, 359 participants were randomized. Primary outcome data at week 8 were obtained for 355 participants (99%). The week 8 PHQ‐9 total score was significantly reduced from baseline for all participants by −1.41 points (95% confidence interval [CI] −1.89, −0.92), but between‐group differences in change scores were not significant (BA: −0.04, 95% CI −0.75, 0.67; AT: −0.16, 95% CI −0.87, 0.55; PS: −0.19, 95% CI −0.90, 0.52).
Conclusion
As the presence of any of the three intervention components did not contribute to a significant additive reduction of depressive symptoms, we cannot make evidence‐based recommendations regarding the use of specific smartphone psychotherapy. |
| doi_str_mv | 10.1111/pcn.13657 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11488626</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3063316947</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4047-3ed132d47f661b08674467413f7957342844aa79288e9f49d64cc476606050b93</originalsourceid><addsrcrecordid>eNp1ks1u1DAQxyMEoqVw4AWQJS7tIa0dO3bCpUIrPlXYFW3PltdxNq4S29hOq_TEI_BcPAZPgrdZKkDCkj80_s3fM-PJsucIHqM0Tpw0xwjTkj3I9hEhMEcVqh-mMy5wjjCie9mTEK4ghBhT9DjbwxWhFYFkP_uxdFEP-labDQiD8NF11ijgwiQ7GzvlhZtAaz1olPMqBH2tQJgGF-0QgDbAiaiViQHc6NgBKYxU_hX4NPZRu04EBeysnzBrQIheRLWZwBi2D4qkKpO3F72-VQ0Ytm5bg_LAC9PY4c4se220FD2IXqf18OPPb9_PL1er5ZcLUECIwHkcm-noafaoFX1Qz3b7QXb59s3F4n1-tnz3YfH6LJcpY5Zj1aS6NIS1lKI1rCgjJE2EW1aXDJOiIkQIVhdVpeqW1A0lUhJGKaSwhOsaH2Sns64b14Nqdglw53Wq38St0PzvG6M7vrHXHCFSVbSgSeFwp-Dt11GFyAcdpOp7YZQdAy_qkiIKISsT-vIf9MqO3qT8OIYUp7-tCUvU0UxJb0Pwqr2PBkG-bRGeWoTftUhiX_wZ_j35uycScDIDN7pX0_-V-GrxeZb8BVDxyr0</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3063316947</pqid></control><display><type>article</type><title>Optimizing smartphone psychotherapy for depressive symptoms in patients with cancer: Multiphase optimization strategy using a decentralized multicenter randomized clinical trial (J‐SUPPORT 2001 Study)</title><source>MEDLINE</source><source>Freely Accessible Japanese Titles</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Akechi, Tatsuo ; Furukawa, Toshiaki A. ; Noma, Hisashi ; Iwata, Hiroji ; Toyama, Tatsuya ; Higaki, Kenji ; Matsuoka, Hiromichi ; Zenda, Sadamoto ; Iwatani, Tsuguo ; Akahane, Kazuhisa ; Inoue, Akira ; Sagara, Yasuaki ; Uchida, Megumi ; Imai, Fuminobu ; Momino, Kanae ; Imaizumi, Gen ; Yamaguchi, Takuhiro ; Mashiko, Tomoe ; Miyaji, Tempei ; Horikoshi, Masaru ; Sakurai, Naomi ; Onishi, Tatsuya ; Kanemitsu, Yukihide ; Murata, Takeshi ; Wanifuchi‐Endo, Yumi ; Kuroda, Hiroaki ; Nishikawa, Ryutaro ; Miyashita, Minoru ; Abe, Masakazu ; Uchitomi, Yosuke</creator><creatorcontrib>Akechi, Tatsuo ; Furukawa, Toshiaki A. ; Noma, Hisashi ; Iwata, Hiroji ; Toyama, Tatsuya ; Higaki, Kenji ; Matsuoka, Hiromichi ; Zenda, Sadamoto ; Iwatani, Tsuguo ; Akahane, Kazuhisa ; Inoue, Akira ; Sagara, Yasuaki ; Uchida, Megumi ; Imai, Fuminobu ; Momino, Kanae ; Imaizumi, Gen ; Yamaguchi, Takuhiro ; Mashiko, Tomoe ; Miyaji, Tempei ; Horikoshi, Masaru ; Sakurai, Naomi ; Onishi, Tatsuya ; Kanemitsu, Yukihide ; Murata, Takeshi ; Wanifuchi‐Endo, Yumi ; Kuroda, Hiroaki ; Nishikawa, Ryutaro ; Miyashita, Minoru ; Abe, Masakazu ; Uchitomi, Yosuke ; J‐SUPPORT 2001 Study group</creatorcontrib><description>Aim
Patients with cancer experience various forms of psychological distress, including depressive symptoms, which can impact quality of life, elevate morbidity risk, and increase medical costs. Psychotherapy and pharmacotherapy are effective for reducing depressive symptoms among patients with cancer, but most patients prefer psychotherapy. This study aimed to develop an efficient and effective smartphone psychotherapy component to address depressive symptom.
Methods
This was a decentralized, parallel‐group, multicenter, open, individually randomized, fully factorial trial. Patients aged ≥20 years with cancer were randomized by the presence/absence of three cognitive‐behavioral therapy (CBT) skills (behavioral activation [BA], assertiveness training [AT], and problem‐solving [PS]) on a smartphone app. All participants received psychoeducation (PE). The primary outcome was change in the patient health questionnaire‐9 (PHQ‐9) total score between baseline and week 8. Secondary outcomes included anxiety.
Results
In total, 359 participants were randomized. Primary outcome data at week 8 were obtained for 355 participants (99%). The week 8 PHQ‐9 total score was significantly reduced from baseline for all participants by −1.41 points (95% confidence interval [CI] −1.89, −0.92), but between‐group differences in change scores were not significant (BA: −0.04, 95% CI −0.75, 0.67; AT: −0.16, 95% CI −0.87, 0.55; PS: −0.19, 95% CI −0.90, 0.52).
Conclusion
As the presence of any of the three intervention components did not contribute to a significant additive reduction of depressive symptoms, we cannot make evidence‐based recommendations regarding the use of specific smartphone psychotherapy.</description><identifier>ISSN: 1323-1316</identifier><identifier>ISSN: 1440-1819</identifier><identifier>EISSN: 1440-1819</identifier><identifier>DOI: 10.1111/pcn.13657</identifier><identifier>PMID: 38468404</identifier><language>eng</language><publisher>Melbourne: John Wiley & Sons Australia, Ltd</publisher><subject>Adult ; Aged ; Cancer ; Cognitive behavioral therapy ; Cognitive Behavioral Therapy - methods ; decentralized clinical trial ; Depression - therapy ; depressive symptoms ; Drug therapy ; Female ; Humans ; Male ; Mental depression ; Middle Aged ; Mobile Applications ; Morbidity ; multiphase optimization strategy ; neoplasm ; Neoplasms - complications ; Neoplasms - therapy ; Outcome Assessment, Health Care ; Patients ; Psychotherapy ; Psychotherapy - methods ; Quality of life ; Regular ; Smartphone ; Smartphones ; smartphone‐based CBT</subject><ispartof>Psychiatry and clinical neurosciences, 2024-06, Vol.78 (6), p.353-361</ispartof><rights>2024 The Authors. published by John Wiley & Sons Australia, Ltd on behalf of Japanese Society of Psychiatry and Neurology.</rights><rights>2024 The Authors. Psychiatry and Clinical Neurosciences published by John Wiley & Sons Australia, Ltd on behalf of Japanese Society of Psychiatry and Neurology.</rights><rights>2024. This article is published under http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c4047-3ed132d47f661b08674467413f7957342844aa79288e9f49d64cc476606050b93</cites><orcidid>0000-0003-1100-7518</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fpcn.13657$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fpcn.13657$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38468404$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Akechi, Tatsuo</creatorcontrib><creatorcontrib>Furukawa, Toshiaki A.</creatorcontrib><creatorcontrib>Noma, Hisashi</creatorcontrib><creatorcontrib>Iwata, Hiroji</creatorcontrib><creatorcontrib>Toyama, Tatsuya</creatorcontrib><creatorcontrib>Higaki, Kenji</creatorcontrib><creatorcontrib>Matsuoka, Hiromichi</creatorcontrib><creatorcontrib>Zenda, Sadamoto</creatorcontrib><creatorcontrib>Iwatani, Tsuguo</creatorcontrib><creatorcontrib>Akahane, Kazuhisa</creatorcontrib><creatorcontrib>Inoue, Akira</creatorcontrib><creatorcontrib>Sagara, Yasuaki</creatorcontrib><creatorcontrib>Uchida, Megumi</creatorcontrib><creatorcontrib>Imai, Fuminobu</creatorcontrib><creatorcontrib>Momino, Kanae</creatorcontrib><creatorcontrib>Imaizumi, Gen</creatorcontrib><creatorcontrib>Yamaguchi, Takuhiro</creatorcontrib><creatorcontrib>Mashiko, Tomoe</creatorcontrib><creatorcontrib>Miyaji, Tempei</creatorcontrib><creatorcontrib>Horikoshi, Masaru</creatorcontrib><creatorcontrib>Sakurai, Naomi</creatorcontrib><creatorcontrib>Onishi, Tatsuya</creatorcontrib><creatorcontrib>Kanemitsu, Yukihide</creatorcontrib><creatorcontrib>Murata, Takeshi</creatorcontrib><creatorcontrib>Wanifuchi‐Endo, Yumi</creatorcontrib><creatorcontrib>Kuroda, Hiroaki</creatorcontrib><creatorcontrib>Nishikawa, Ryutaro</creatorcontrib><creatorcontrib>Miyashita, Minoru</creatorcontrib><creatorcontrib>Abe, Masakazu</creatorcontrib><creatorcontrib>Uchitomi, Yosuke</creatorcontrib><creatorcontrib>J‐SUPPORT 2001 Study group</creatorcontrib><title>Optimizing smartphone psychotherapy for depressive symptoms in patients with cancer: Multiphase optimization strategy using a decentralized multicenter randomized clinical trial (J‐SUPPORT 2001 Study)</title><title>Psychiatry and clinical neurosciences</title><addtitle>Psychiatry Clin Neurosci</addtitle><description>Aim
Patients with cancer experience various forms of psychological distress, including depressive symptoms, which can impact quality of life, elevate morbidity risk, and increase medical costs. Psychotherapy and pharmacotherapy are effective for reducing depressive symptoms among patients with cancer, but most patients prefer psychotherapy. This study aimed to develop an efficient and effective smartphone psychotherapy component to address depressive symptom.
Methods
This was a decentralized, parallel‐group, multicenter, open, individually randomized, fully factorial trial. Patients aged ≥20 years with cancer were randomized by the presence/absence of three cognitive‐behavioral therapy (CBT) skills (behavioral activation [BA], assertiveness training [AT], and problem‐solving [PS]) on a smartphone app. All participants received psychoeducation (PE). The primary outcome was change in the patient health questionnaire‐9 (PHQ‐9) total score between baseline and week 8. Secondary outcomes included anxiety.
Results
In total, 359 participants were randomized. Primary outcome data at week 8 were obtained for 355 participants (99%). The week 8 PHQ‐9 total score was significantly reduced from baseline for all participants by −1.41 points (95% confidence interval [CI] −1.89, −0.92), but between‐group differences in change scores were not significant (BA: −0.04, 95% CI −0.75, 0.67; AT: −0.16, 95% CI −0.87, 0.55; PS: −0.19, 95% CI −0.90, 0.52).
Conclusion
As the presence of any of the three intervention components did not contribute to a significant additive reduction of depressive symptoms, we cannot make evidence‐based recommendations regarding the use of specific smartphone psychotherapy.</description><subject>Adult</subject><subject>Aged</subject><subject>Cancer</subject><subject>Cognitive behavioral therapy</subject><subject>Cognitive Behavioral Therapy - methods</subject><subject>decentralized clinical trial</subject><subject>Depression - therapy</subject><subject>depressive symptoms</subject><subject>Drug therapy</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Mental depression</subject><subject>Middle Aged</subject><subject>Mobile Applications</subject><subject>Morbidity</subject><subject>multiphase optimization strategy</subject><subject>neoplasm</subject><subject>Neoplasms - complications</subject><subject>Neoplasms - therapy</subject><subject>Outcome Assessment, Health Care</subject><subject>Patients</subject><subject>Psychotherapy</subject><subject>Psychotherapy - methods</subject><subject>Quality of life</subject><subject>Regular</subject><subject>Smartphone</subject><subject>Smartphones</subject><subject>smartphone‐based CBT</subject><issn>1323-1316</issn><issn>1440-1819</issn><issn>1440-1819</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>EIF</sourceid><recordid>eNp1ks1u1DAQxyMEoqVw4AWQJS7tIa0dO3bCpUIrPlXYFW3PltdxNq4S29hOq_TEI_BcPAZPgrdZKkDCkj80_s3fM-PJsucIHqM0Tpw0xwjTkj3I9hEhMEcVqh-mMy5wjjCie9mTEK4ghBhT9DjbwxWhFYFkP_uxdFEP-labDQiD8NF11ijgwiQ7GzvlhZtAaz1olPMqBH2tQJgGF-0QgDbAiaiViQHc6NgBKYxU_hX4NPZRu04EBeysnzBrQIheRLWZwBi2D4qkKpO3F72-VQ0Ytm5bg_LAC9PY4c4se220FD2IXqf18OPPb9_PL1er5ZcLUECIwHkcm-noafaoFX1Qz3b7QXb59s3F4n1-tnz3YfH6LJcpY5Zj1aS6NIS1lKI1rCgjJE2EW1aXDJOiIkQIVhdVpeqW1A0lUhJGKaSwhOsaH2Sns64b14Nqdglw53Wq38St0PzvG6M7vrHXHCFSVbSgSeFwp-Dt11GFyAcdpOp7YZQdAy_qkiIKISsT-vIf9MqO3qT8OIYUp7-tCUvU0UxJb0Pwqr2PBkG-bRGeWoTftUhiX_wZ_j35uycScDIDN7pX0_-V-GrxeZb8BVDxyr0</recordid><startdate>202406</startdate><enddate>202406</enddate><creator>Akechi, Tatsuo</creator><creator>Furukawa, Toshiaki A.</creator><creator>Noma, Hisashi</creator><creator>Iwata, Hiroji</creator><creator>Toyama, Tatsuya</creator><creator>Higaki, Kenji</creator><creator>Matsuoka, Hiromichi</creator><creator>Zenda, Sadamoto</creator><creator>Iwatani, Tsuguo</creator><creator>Akahane, Kazuhisa</creator><creator>Inoue, Akira</creator><creator>Sagara, Yasuaki</creator><creator>Uchida, Megumi</creator><creator>Imai, Fuminobu</creator><creator>Momino, Kanae</creator><creator>Imaizumi, Gen</creator><creator>Yamaguchi, Takuhiro</creator><creator>Mashiko, Tomoe</creator><creator>Miyaji, Tempei</creator><creator>Horikoshi, Masaru</creator><creator>Sakurai, Naomi</creator><creator>Onishi, Tatsuya</creator><creator>Kanemitsu, Yukihide</creator><creator>Murata, Takeshi</creator><creator>Wanifuchi‐Endo, Yumi</creator><creator>Kuroda, Hiroaki</creator><creator>Nishikawa, Ryutaro</creator><creator>Miyashita, Minoru</creator><creator>Abe, Masakazu</creator><creator>Uchitomi, Yosuke</creator><general>John Wiley & Sons Australia, Ltd</general><general>Wiley Subscription Services, Inc</general><scope>24P</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-1100-7518</orcidid></search><sort><creationdate>202406</creationdate><title>Optimizing smartphone psychotherapy for depressive symptoms in patients with cancer: Multiphase optimization strategy using a decentralized multicenter randomized clinical trial (J‐SUPPORT 2001 Study)</title><author>Akechi, Tatsuo ; Furukawa, Toshiaki A. ; Noma, Hisashi ; Iwata, Hiroji ; Toyama, Tatsuya ; Higaki, Kenji ; Matsuoka, Hiromichi ; Zenda, Sadamoto ; Iwatani, Tsuguo ; Akahane, Kazuhisa ; Inoue, Akira ; Sagara, Yasuaki ; Uchida, Megumi ; Imai, Fuminobu ; Momino, Kanae ; Imaizumi, Gen ; Yamaguchi, Takuhiro ; Mashiko, Tomoe ; Miyaji, Tempei ; Horikoshi, Masaru ; Sakurai, Naomi ; Onishi, Tatsuya ; Kanemitsu, Yukihide ; Murata, Takeshi ; Wanifuchi‐Endo, Yumi ; Kuroda, Hiroaki ; Nishikawa, Ryutaro ; Miyashita, Minoru ; Abe, Masakazu ; Uchitomi, Yosuke</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4047-3ed132d47f661b08674467413f7957342844aa79288e9f49d64cc476606050b93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Cancer</topic><topic>Cognitive behavioral therapy</topic><topic>Cognitive Behavioral Therapy - methods</topic><topic>decentralized clinical trial</topic><topic>Depression - therapy</topic><topic>depressive symptoms</topic><topic>Drug therapy</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Mental depression</topic><topic>Middle Aged</topic><topic>Mobile Applications</topic><topic>Morbidity</topic><topic>multiphase optimization strategy</topic><topic>neoplasm</topic><topic>Neoplasms - complications</topic><topic>Neoplasms - therapy</topic><topic>Outcome Assessment, Health Care</topic><topic>Patients</topic><topic>Psychotherapy</topic><topic>Psychotherapy - methods</topic><topic>Quality of life</topic><topic>Regular</topic><topic>Smartphone</topic><topic>Smartphones</topic><topic>smartphone‐based CBT</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Akechi, Tatsuo</creatorcontrib><creatorcontrib>Furukawa, Toshiaki A.</creatorcontrib><creatorcontrib>Noma, Hisashi</creatorcontrib><creatorcontrib>Iwata, Hiroji</creatorcontrib><creatorcontrib>Toyama, Tatsuya</creatorcontrib><creatorcontrib>Higaki, Kenji</creatorcontrib><creatorcontrib>Matsuoka, Hiromichi</creatorcontrib><creatorcontrib>Zenda, Sadamoto</creatorcontrib><creatorcontrib>Iwatani, Tsuguo</creatorcontrib><creatorcontrib>Akahane, Kazuhisa</creatorcontrib><creatorcontrib>Inoue, Akira</creatorcontrib><creatorcontrib>Sagara, Yasuaki</creatorcontrib><creatorcontrib>Uchida, Megumi</creatorcontrib><creatorcontrib>Imai, Fuminobu</creatorcontrib><creatorcontrib>Momino, Kanae</creatorcontrib><creatorcontrib>Imaizumi, Gen</creatorcontrib><creatorcontrib>Yamaguchi, Takuhiro</creatorcontrib><creatorcontrib>Mashiko, Tomoe</creatorcontrib><creatorcontrib>Miyaji, Tempei</creatorcontrib><creatorcontrib>Horikoshi, Masaru</creatorcontrib><creatorcontrib>Sakurai, Naomi</creatorcontrib><creatorcontrib>Onishi, Tatsuya</creatorcontrib><creatorcontrib>Kanemitsu, Yukihide</creatorcontrib><creatorcontrib>Murata, Takeshi</creatorcontrib><creatorcontrib>Wanifuchi‐Endo, Yumi</creatorcontrib><creatorcontrib>Kuroda, Hiroaki</creatorcontrib><creatorcontrib>Nishikawa, Ryutaro</creatorcontrib><creatorcontrib>Miyashita, Minoru</creatorcontrib><creatorcontrib>Abe, Masakazu</creatorcontrib><creatorcontrib>Uchitomi, Yosuke</creatorcontrib><creatorcontrib>J‐SUPPORT 2001 Study group</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Psychiatry and clinical neurosciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Akechi, Tatsuo</au><au>Furukawa, Toshiaki A.</au><au>Noma, Hisashi</au><au>Iwata, Hiroji</au><au>Toyama, Tatsuya</au><au>Higaki, Kenji</au><au>Matsuoka, Hiromichi</au><au>Zenda, Sadamoto</au><au>Iwatani, Tsuguo</au><au>Akahane, Kazuhisa</au><au>Inoue, Akira</au><au>Sagara, Yasuaki</au><au>Uchida, Megumi</au><au>Imai, Fuminobu</au><au>Momino, Kanae</au><au>Imaizumi, Gen</au><au>Yamaguchi, Takuhiro</au><au>Mashiko, Tomoe</au><au>Miyaji, Tempei</au><au>Horikoshi, Masaru</au><au>Sakurai, Naomi</au><au>Onishi, Tatsuya</au><au>Kanemitsu, Yukihide</au><au>Murata, Takeshi</au><au>Wanifuchi‐Endo, Yumi</au><au>Kuroda, Hiroaki</au><au>Nishikawa, Ryutaro</au><au>Miyashita, Minoru</au><au>Abe, Masakazu</au><au>Uchitomi, Yosuke</au><aucorp>J‐SUPPORT 2001 Study group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Optimizing smartphone psychotherapy for depressive symptoms in patients with cancer: Multiphase optimization strategy using a decentralized multicenter randomized clinical trial (J‐SUPPORT 2001 Study)</atitle><jtitle>Psychiatry and clinical neurosciences</jtitle><addtitle>Psychiatry Clin Neurosci</addtitle><date>2024-06</date><risdate>2024</risdate><volume>78</volume><issue>6</issue><spage>353</spage><epage>361</epage><pages>353-361</pages><issn>1323-1316</issn><issn>1440-1819</issn><eissn>1440-1819</eissn><abstract>Aim
Patients with cancer experience various forms of psychological distress, including depressive symptoms, which can impact quality of life, elevate morbidity risk, and increase medical costs. Psychotherapy and pharmacotherapy are effective for reducing depressive symptoms among patients with cancer, but most patients prefer psychotherapy. This study aimed to develop an efficient and effective smartphone psychotherapy component to address depressive symptom.
Methods
This was a decentralized, parallel‐group, multicenter, open, individually randomized, fully factorial trial. Patients aged ≥20 years with cancer were randomized by the presence/absence of three cognitive‐behavioral therapy (CBT) skills (behavioral activation [BA], assertiveness training [AT], and problem‐solving [PS]) on a smartphone app. All participants received psychoeducation (PE). The primary outcome was change in the patient health questionnaire‐9 (PHQ‐9) total score between baseline and week 8. Secondary outcomes included anxiety.
Results
In total, 359 participants were randomized. Primary outcome data at week 8 were obtained for 355 participants (99%). The week 8 PHQ‐9 total score was significantly reduced from baseline for all participants by −1.41 points (95% confidence interval [CI] −1.89, −0.92), but between‐group differences in change scores were not significant (BA: −0.04, 95% CI −0.75, 0.67; AT: −0.16, 95% CI −0.87, 0.55; PS: −0.19, 95% CI −0.90, 0.52).
Conclusion
As the presence of any of the three intervention components did not contribute to a significant additive reduction of depressive symptoms, we cannot make evidence‐based recommendations regarding the use of specific smartphone psychotherapy.</abstract><cop>Melbourne</cop><pub>John Wiley & Sons Australia, Ltd</pub><pmid>38468404</pmid><doi>10.1111/pcn.13657</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-1100-7518</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1323-1316 |
| ispartof | Psychiatry and clinical neurosciences, 2024-06, Vol.78 (6), p.353-361 |
| issn | 1323-1316 1440-1819 1440-1819 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11488626 |
| source | MEDLINE; Freely Accessible Japanese Titles; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Aged Cancer Cognitive behavioral therapy Cognitive Behavioral Therapy - methods decentralized clinical trial Depression - therapy depressive symptoms Drug therapy Female Humans Male Mental depression Middle Aged Mobile Applications Morbidity multiphase optimization strategy neoplasm Neoplasms - complications Neoplasms - therapy Outcome Assessment, Health Care Patients Psychotherapy Psychotherapy - methods Quality of life Regular Smartphone Smartphones smartphone‐based CBT |
| title | Optimizing smartphone psychotherapy for depressive symptoms in patients with cancer: Multiphase optimization strategy using a decentralized multicenter randomized clinical trial (J‐SUPPORT 2001 Study) |
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