Growth hormone‐releasing hormone deficiency confers extended lifespan and metabolic resilience during high‐fat feeding in mid and late life

Growth hormone‐releasing hormone‐deficient (GHRH‐KO) mice have previously been characterized by lower body weight, disproportionately high body fat accumulation, preferential metabolism of lipids compared to carbohydrates, improved insulin sensitivity, and an extended lifespan. That these mice are l...

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Veröffentlicht in:	Aging cell 2024-09, Vol.23 (9), p.e14238-n/a
Hauptverfasser:	Adkins‐Jablonsky, Joseph, Lasher, Alexander Tate, Patki, Amit, Nagarajan, Akash, Sun, Liou Y.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose tissue Aging Body fat Body weight Calorimetry Carbohydrates Chronic illnesses Diabetes Diabetes mellitus Diet Fat metabolism Females Glucose metabolism Glucose tolerance Growth hormone-releasing hormone Growth hormones High fat diet Insulin Insulin resistance Intervention Life span Lipid metabolism longevity Males Metabolism Nutrient deficiency Obesity Physiology Respiration Side effects Statistical analysis
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