Identification of potential novel targets for treating inflammatory bowel disease using Mendelian randomization analysis

Background Inflammatory bowel disease (IBD) is a complex autoimmune disorder, although some medications are available for its treatment. However, the long-term efficacy of these drugs remains unsatisfactory. Therefore, there is a need to develop novel drug targets for IBD treatment. Methods We condu...

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Veröffentlicht in:	International journal of colorectal disease 2024-10, Vol.39 (1), p.165, Article 165
Hauptverfasser:	Fan, Ji-Chang, Lu, Yuan, Gan, Jin-Heng, Lu, Hao
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiopoietin-Like Protein 3 Bayes Theorem Bayesian analysis Colitis, Ulcerative - drug therapy Colitis, Ulcerative - genetics Crohn's disease Fc receptors Gastroenterology Genetic diversity Genetic Predisposition to Disease Genome-wide association studies Genome-Wide Association Study Genomic analysis Hepatology Humans Inflammatory bowel disease Inflammatory bowel diseases Inflammatory Bowel Diseases - drug therapy Inflammatory Bowel Diseases - genetics Internal Medicine Intestine Localization Medicine Medicine & Public Health Mendelian Randomization Analysis Molecular Targeted Therapy Phenotype Plasma proteins Polymorphism, Single Nucleotide - genetics Proctology Proteins Side effects Surgery Therapeutic targets Ulcerative colitis
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