What Contributes to the Minimum Inhibitory Concentration? Beyond β-Lactamase Gene Detection in Klebsiella pneumoniae

Abstract Background Klebsiella pneumoniae is capable of resistance to β-lactam antibiotics through expression of β-lactamases (both chromosomal and plasmid-encoded) and downregulation of outer membrane porins. However, the extent to which these mechanisms interplay in a resistant phenotype is not we...

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Veröffentlicht in:	The Journal of infectious diseases 2024-10, Vol.230 (4), p.e777-e788
Hauptverfasser:	Maclean, Alyssa K W, Morrow, Stacey, Niu, Fang, Hanson, Nancy D
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - pharmacology Antibiotics beta-Lactam Resistance - genetics beta-Lactamases - genetics beta-Lactamases - metabolism beta-Lactams - pharmacology Cefotaxime Ceftazidime Cephalosporins Genomes Humans Klebsiella Infections - microbiology Klebsiella pneumoniae Klebsiella pneumoniae - drug effects Klebsiella pneumoniae - enzymology Klebsiella pneumoniae - genetics Major Meropenem Microbial Sensitivity Tests Minimum inhibitory concentration Phenotypes Piperacillin-tazobactam Plasmids - genetics Porins Porins - genetics Porins - metabolism Whole Genome Sequencing β Lactamase β-Lactam antibiotics
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