The Role of Cyclin d1 in Radiotherapy Resistance of Advance Stage Nasopharyngeal Carcinoma: A Systematic Review
One of the biggest therapy challenges for nasopharyngeal cancer (NPC) is still radioresistance. The radioresistance in NPC is thought to be caused by cyclin D1 overexpression. The purpose of this study was to determine how cyclin D1 contributes to radiation resistance in NPC. Adhering to the PRISM...
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| Veröffentlicht in: | Asian Pacific Journal of Cancer Prevention 2024-07, Vol.25 (7), p.2211-2218 |
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| container_title | Asian Pacific Journal of Cancer Prevention |
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| creator | Romdhoni, Achmad Chusnu Rajanagara, Arya Satya Albab, Chabib Fachry Waskito, Langgeng Agung Wibowo, Idznika Nurannisa Yunus, Mohd Razif Mohamad |
| description | One of the biggest therapy challenges for nasopharyngeal cancer (NPC) is still radioresistance. The radioresistance in NPC is thought to be caused by cyclin D1 overexpression. The purpose of this study was to determine how cyclin D1 contributes to radiation resistance in NPC.
Adhering to the PRISMA guidelines, we systematically reviewed studies on cyclin D1-associated radioresistance in NPC from 2012 until 2023. From our search, 15 studies were included.
Cyclin D1's role in radiotherapy resistance is elucidated through several mechanisms, notably SHP-1 and B-catenin. Overexpression of SHP-1 led to an increase in cyclin D1, a higher proportion of cells in the S-phase, and radioresistance. Conversely, inhibiting β-catenin and cyclin D1 expression enhances radiation sensitivity.
In conclusion, Cyclin D1 has a strong correlation with radiation resistance; downregulation of the protein increases radiosensitivity, while overexpression of the protein promotes radioresistance. |
| doi_str_mv | 10.31557/APJCP.2024.25.7.2211 |
| format | Article |
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Adhering to the PRISMA guidelines, we systematically reviewed studies on cyclin D1-associated radioresistance in NPC from 2012 until 2023. From our search, 15 studies were included.
Cyclin D1's role in radiotherapy resistance is elucidated through several mechanisms, notably SHP-1 and B-catenin. Overexpression of SHP-1 led to an increase in cyclin D1, a higher proportion of cells in the S-phase, and radioresistance. Conversely, inhibiting β-catenin and cyclin D1 expression enhances radiation sensitivity.
In conclusion, Cyclin D1 has a strong correlation with radiation resistance; downregulation of the protein increases radiosensitivity, while overexpression of the protein promotes radioresistance.</description><identifier>ISSN: 2476-762X</identifier><identifier>ISSN: 1513-7368</identifier><identifier>EISSN: 2476-762X</identifier><identifier>DOI: 10.31557/APJCP.2024.25.7.2211</identifier><identifier>PMID: 39068551</identifier><language>eng</language><publisher>Thailand: West Asia Organization for Cancer Prevention</publisher><subject>beta Catenin - metabolism ; Cyclin D1 - metabolism ; Humans ; Nasopharyngeal Carcinoma - metabolism ; Nasopharyngeal Carcinoma - pathology ; Nasopharyngeal Carcinoma - radiotherapy ; Nasopharyngeal Neoplasms - metabolism ; Nasopharyngeal Neoplasms - pathology ; Nasopharyngeal Neoplasms - radiotherapy ; Neoplasm Staging ; Prognosis ; Protein Tyrosine Phosphatase, Non-Receptor Type 6 - metabolism ; Radiation Tolerance ; Review</subject><ispartof>Asian Pacific Journal of Cancer Prevention, 2024-07, Vol.25 (7), p.2211-2218</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0009-0009-5959-4900 ; 0000-0002-9367-3268 ; 0000-0002-8563-9000 ; 0000-0001-7999-2003 ; 0000-0002-9400-1973 ; 0000-0002-0298-7182</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11480630/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11480630/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39068551$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Romdhoni, Achmad Chusnu</creatorcontrib><creatorcontrib>Rajanagara, Arya Satya</creatorcontrib><creatorcontrib>Albab, Chabib Fachry</creatorcontrib><creatorcontrib>Waskito, Langgeng Agung</creatorcontrib><creatorcontrib>Wibowo, Idznika Nurannisa</creatorcontrib><creatorcontrib>Yunus, Mohd Razif Mohamad</creatorcontrib><title>The Role of Cyclin d1 in Radiotherapy Resistance of Advance Stage Nasopharyngeal Carcinoma: A Systematic Review</title><title>Asian Pacific Journal of Cancer Prevention</title><addtitle>Asian Pac J Cancer Prev</addtitle><description>One of the biggest therapy challenges for nasopharyngeal cancer (NPC) is still radioresistance. The radioresistance in NPC is thought to be caused by cyclin D1 overexpression. The purpose of this study was to determine how cyclin D1 contributes to radiation resistance in NPC.
Adhering to the PRISMA guidelines, we systematically reviewed studies on cyclin D1-associated radioresistance in NPC from 2012 until 2023. From our search, 15 studies were included.
Cyclin D1's role in radiotherapy resistance is elucidated through several mechanisms, notably SHP-1 and B-catenin. Overexpression of SHP-1 led to an increase in cyclin D1, a higher proportion of cells in the S-phase, and radioresistance. Conversely, inhibiting β-catenin and cyclin D1 expression enhances radiation sensitivity.
In conclusion, Cyclin D1 has a strong correlation with radiation resistance; downregulation of the protein increases radiosensitivity, while overexpression of the protein promotes radioresistance.</description><subject>beta Catenin - metabolism</subject><subject>Cyclin D1 - metabolism</subject><subject>Humans</subject><subject>Nasopharyngeal Carcinoma - metabolism</subject><subject>Nasopharyngeal Carcinoma - pathology</subject><subject>Nasopharyngeal Carcinoma - radiotherapy</subject><subject>Nasopharyngeal Neoplasms - metabolism</subject><subject>Nasopharyngeal Neoplasms - pathology</subject><subject>Nasopharyngeal Neoplasms - radiotherapy</subject><subject>Neoplasm Staging</subject><subject>Prognosis</subject><subject>Protein Tyrosine Phosphatase, Non-Receptor Type 6 - metabolism</subject><subject>Radiation Tolerance</subject><subject>Review</subject><issn>2476-762X</issn><issn>1513-7368</issn><issn>2476-762X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkdtOwzAMhiME4vwIoLzASg5NmnKDpoqjEKBtF9xFbuptQV0zNWVob0_ZAMGNbcn-P1v-CTnjLJFcqexi-PJQvCSCiTQRKskSITjfIYcizfQg0-J19099QI5ifGMsVSZT--RA5kwbpfghCZM50lGokYYpLdau9g2tOO3jCCofujm2sFzTEUYfO2jcZm5YrTbluIMZ0ieIYTmHdt3MEGpaQOt8ExZwSYd0vI4dLqDzrkesPH6ckL0p1BFPv_MxmdxcT4q7wePz7X0xfBw4IUw3yCXX3CijscrT1BiHmk1LKdFwdMglYyVoYBlKDYalRjstqrzMs6pSJaA8Jldb7PK9XGDlsOlaqO2y9Yv-UBvA2_-dxs_tLKws56lhWrKeoLYE14YYW5z-ijmzGwfsxgH75YAVymb2y4Fed_5386_q5-XyEzdUhFI</recordid><startdate>20240701</startdate><enddate>20240701</enddate><creator>Romdhoni, Achmad Chusnu</creator><creator>Rajanagara, Arya Satya</creator><creator>Albab, Chabib Fachry</creator><creator>Waskito, Langgeng Agung</creator><creator>Wibowo, Idznika Nurannisa</creator><creator>Yunus, Mohd Razif Mohamad</creator><general>West Asia Organization for Cancer Prevention</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope><orcidid>https://orcid.org/0009-0009-5959-4900</orcidid><orcidid>https://orcid.org/0000-0002-9367-3268</orcidid><orcidid>https://orcid.org/0000-0002-8563-9000</orcidid><orcidid>https://orcid.org/0000-0001-7999-2003</orcidid><orcidid>https://orcid.org/0000-0002-9400-1973</orcidid><orcidid>https://orcid.org/0000-0002-0298-7182</orcidid></search><sort><creationdate>20240701</creationdate><title>The Role of Cyclin d1 in Radiotherapy Resistance of Advance Stage Nasopharyngeal Carcinoma: A Systematic Review</title><author>Romdhoni, Achmad Chusnu ; Rajanagara, Arya Satya ; Albab, Chabib Fachry ; Waskito, Langgeng Agung ; Wibowo, Idznika Nurannisa ; Yunus, Mohd Razif Mohamad</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c228t-931618586ed94488ce60fb33e81ece1300ba6a07e36a80486c62d9b97dd5bae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>beta Catenin - metabolism</topic><topic>Cyclin D1 - metabolism</topic><topic>Humans</topic><topic>Nasopharyngeal Carcinoma - metabolism</topic><topic>Nasopharyngeal Carcinoma - pathology</topic><topic>Nasopharyngeal Carcinoma - radiotherapy</topic><topic>Nasopharyngeal Neoplasms - metabolism</topic><topic>Nasopharyngeal Neoplasms - pathology</topic><topic>Nasopharyngeal Neoplasms - radiotherapy</topic><topic>Neoplasm Staging</topic><topic>Prognosis</topic><topic>Protein Tyrosine Phosphatase, Non-Receptor Type 6 - metabolism</topic><topic>Radiation Tolerance</topic><topic>Review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Romdhoni, Achmad Chusnu</creatorcontrib><creatorcontrib>Rajanagara, Arya Satya</creatorcontrib><creatorcontrib>Albab, Chabib Fachry</creatorcontrib><creatorcontrib>Waskito, Langgeng Agung</creatorcontrib><creatorcontrib>Wibowo, Idznika Nurannisa</creatorcontrib><creatorcontrib>Yunus, Mohd Razif Mohamad</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Asian Pacific Journal of Cancer Prevention</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Romdhoni, Achmad Chusnu</au><au>Rajanagara, Arya Satya</au><au>Albab, Chabib Fachry</au><au>Waskito, Langgeng Agung</au><au>Wibowo, Idznika Nurannisa</au><au>Yunus, Mohd Razif Mohamad</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Role of Cyclin d1 in Radiotherapy Resistance of Advance Stage Nasopharyngeal Carcinoma: A Systematic Review</atitle><jtitle>Asian Pacific Journal of Cancer Prevention</jtitle><addtitle>Asian Pac J Cancer Prev</addtitle><date>2024-07-01</date><risdate>2024</risdate><volume>25</volume><issue>7</issue><spage>2211</spage><epage>2218</epage><pages>2211-2218</pages><issn>2476-762X</issn><issn>1513-7368</issn><eissn>2476-762X</eissn><abstract>One of the biggest therapy challenges for nasopharyngeal cancer (NPC) is still radioresistance. The radioresistance in NPC is thought to be caused by cyclin D1 overexpression. The purpose of this study was to determine how cyclin D1 contributes to radiation resistance in NPC.
Adhering to the PRISMA guidelines, we systematically reviewed studies on cyclin D1-associated radioresistance in NPC from 2012 until 2023. From our search, 15 studies were included.
Cyclin D1's role in radiotherapy resistance is elucidated through several mechanisms, notably SHP-1 and B-catenin. Overexpression of SHP-1 led to an increase in cyclin D1, a higher proportion of cells in the S-phase, and radioresistance. Conversely, inhibiting β-catenin and cyclin D1 expression enhances radiation sensitivity.
In conclusion, Cyclin D1 has a strong correlation with radiation resistance; downregulation of the protein increases radiosensitivity, while overexpression of the protein promotes radioresistance.</abstract><cop>Thailand</cop><pub>West Asia Organization for Cancer Prevention</pub><pmid>39068551</pmid><doi>10.31557/APJCP.2024.25.7.2211</doi><tpages>8</tpages><orcidid>https://orcid.org/0009-0009-5959-4900</orcidid><orcidid>https://orcid.org/0000-0002-9367-3268</orcidid><orcidid>https://orcid.org/0000-0002-8563-9000</orcidid><orcidid>https://orcid.org/0000-0001-7999-2003</orcidid><orcidid>https://orcid.org/0000-0002-9400-1973</orcidid><orcidid>https://orcid.org/0000-0002-0298-7182</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Asian Pacific Journal of Cancer Prevention, 2024-07, Vol.25 (7), p.2211-2218 |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free E- Journals |
| subjects | beta Catenin - metabolism Cyclin D1 - metabolism Humans Nasopharyngeal Carcinoma - metabolism Nasopharyngeal Carcinoma - pathology Nasopharyngeal Carcinoma - radiotherapy Nasopharyngeal Neoplasms - metabolism Nasopharyngeal Neoplasms - pathology Nasopharyngeal Neoplasms - radiotherapy Neoplasm Staging Prognosis Protein Tyrosine Phosphatase, Non-Receptor Type 6 - metabolism Radiation Tolerance Review |
| title | The Role of Cyclin d1 in Radiotherapy Resistance of Advance Stage Nasopharyngeal Carcinoma: A Systematic Review |
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