Transcriptomic analysis of BM-MSCs identified EGR1 as a transcription factor to fully exploit their therapeutic potential

Bone marrow-mesenchymal stromal cells (BM-MSCs) are key components of the BM niche, where they regulate hematopoietic stem progenitor cell (HSPC) homeostasis by direct contact and secreting soluble factors. BM-MSCs also protect the BM niche from excessive inflammation by releasing anti-inflammatory...

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Veröffentlicht in:	Biochimica et biophysica acta. Molecular cell research 2024-12, Vol.1871 (8), p.119818, Article 119818
Hauptverfasser:	Santi, Ludovica, Beretta, Stefano, Berti, Margherita, Savoia, Evelyn Oliva, Passerini, Laura, Mancino, Marilena, De Ponti, Giada, Alberti, Gaia, Quaranta, Pamela, Basso-Ricci, Luca, Avanzini, Maria Antonietta, Merelli, Ivan, Scala, Serena, Ferrari, Samuele, Aiuti, Alessandro, Bernardo, Maria Ester, Crippa, Stefania
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-inflammatory response Bone Marrow Cells - metabolism Bone marrow-mesenchymal stromal cells (BM-MSCs) Cells, Cultured Early Growth Response Protein 1 - genetics Early Growth Response Protein 1 - metabolism Gene Expression Profiling Hematopoietic Stem Cells - metabolism Hematopoietic support Humans Mesenchymal Stem Cells - metabolism MSC reprogramming Research Paper Transcriptome Transcriptomic analysis
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