Food and Microbiota Metabolites Associate with Cognitive Decline in Older Subjects: A 12‐Year Prospective Study
Scope Diet is considered an important modulator of cognitive decline and dementia, but the available evidence is, however, still fragmented and often inconsistent. Methods and Results The article studies the long‐term prospective Three‐City Cohort, which consists of two separate nested case‐control...
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| Veröffentlicht in: | Molecular nutrition & food research 2021-12, Vol.65 (23), p.e2100606-n/a |
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| creator | González‐Domínguez, Raúl Castellano‐Escuder, Pol Carmona, Francisco Lefèvre‐Arbogast, Sophie Low, Dorrain Y. Du Preez, Andrea Ruigrok, Silvie R. Manach, Claudine Urpi‐Sarda, Mireia Korosi, Aniko Lucassen, Paul J. Aigner, Ludwig Pallàs, Mercè Thuret, Sandrine Samieri, Cécilia Sánchez‐Pla, Alex Andres‐Lacueva, Cristina |
| description | Scope
Diet is considered an important modulator of cognitive decline and dementia, but the available evidence is, however, still fragmented and often inconsistent.
Methods and Results
The article studies the long‐term prospective Three‐City Cohort, which consists of two separate nested case‐control sample sets from different geographic regions (Bordeaux, n = 418; Dijon, n = 424). Cognitive decline is evaluated through five neuropsychological tests (Mini‐Mental State Examination, Benton Visual Retention Test, Isaac's Set Test, Trail‐Making Test part A, and Trail‐Making Test part B). The food‐related and microbiota‐derived circulating metabolome is studied in participants free of dementia at baseline, by subjecting serum samples to large‐scale quantitative metabolomics analysis. A protective association is found between metabolites derived from cocoa, coffee, mushrooms, red wine, the microbial metabolism of polyphenol‐rich foods, and cognitive decline, as well as a negative association with metabolites related to unhealthy dietary components, such as artificial sweeteners and alcohol.
Conclusion
These results provide insight into the early metabolic events that are associated with the later risk to develop cognitive decline within the crosstalk between diet, gut microbiota and the endogenous metabolism, which can help identify potential targets for preventive and therapeutic strategies to preserve cognitive health.
A large‐scale quantitative metabolomics platform is employed to obtain a deeper insight into the role of diet in the early onset of cognitive decline. Strong evidence supports a protective association between metabolites derived from cocoa, coffee, mushrooms, red wine, the microbial metabolism of polyphenol‐rich foods and cognitive decline. The article also finds a negative association with metabolites related to unhealthy dietary components, such as artificial sweeteners and alcohol. |
| doi_str_mv | 10.1002/mnfr.202100606 |
| format | Article |
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Diet is considered an important modulator of cognitive decline and dementia, but the available evidence is, however, still fragmented and often inconsistent.
Methods and Results
The article studies the long‐term prospective Three‐City Cohort, which consists of two separate nested case‐control sample sets from different geographic regions (Bordeaux, n = 418; Dijon, n = 424). Cognitive decline is evaluated through five neuropsychological tests (Mini‐Mental State Examination, Benton Visual Retention Test, Isaac's Set Test, Trail‐Making Test part A, and Trail‐Making Test part B). The food‐related and microbiota‐derived circulating metabolome is studied in participants free of dementia at baseline, by subjecting serum samples to large‐scale quantitative metabolomics analysis. A protective association is found between metabolites derived from cocoa, coffee, mushrooms, red wine, the microbial metabolism of polyphenol‐rich foods, and cognitive decline, as well as a negative association with metabolites related to unhealthy dietary components, such as artificial sweeteners and alcohol.
Conclusion
These results provide insight into the early metabolic events that are associated with the later risk to develop cognitive decline within the crosstalk between diet, gut microbiota and the endogenous metabolism, which can help identify potential targets for preventive and therapeutic strategies to preserve cognitive health.
A large‐scale quantitative metabolomics platform is employed to obtain a deeper insight into the role of diet in the early onset of cognitive decline. Strong evidence supports a protective association between metabolites derived from cocoa, coffee, mushrooms, red wine, the microbial metabolism of polyphenol‐rich foods and cognitive decline. The article also finds a negative association with metabolites related to unhealthy dietary components, such as artificial sweeteners and alcohol.</description><identifier>ISSN: 1613-4125</identifier><identifier>ISSN: 1613-4133</identifier><identifier>EISSN: 1613-4133</identifier><identifier>DOI: 10.1002/mnfr.202100606</identifier><identifier>PMID: 34661340</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>Aged ; Cocoa ; Coffee ; Cognitive ability ; cognitive decline ; Cognitive Dysfunction - etiology ; Crosstalk ; Dementia ; Dementia disorders ; Diet ; Food ; Food and Nutrition ; food metabolome ; Gastrointestinal Microbiome ; gut microbiota ; Humans ; Intestinal microflora ; Life Sciences ; Metabolism ; Metabolites ; Metabolomics ; Microbiota ; Microorganisms ; Prospective Studies ; Sweeteners ; Target recognition ; Wines</subject><ispartof>Molecular nutrition & food research, 2021-12, Vol.65 (23), p.e2100606-n/a</ispartof><rights>2021 The Authors. Molecular Nutrition & Food Research published by Wiley‐VCH GmbH</rights><rights>2021 The Authors. Molecular Nutrition & Food Research published by Wiley-VCH GmbH.</rights><rights>2021. This article is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Attribution</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4981-a62c0c4e825dc2db86b0a6156649d8dfaec31e469ab6e32d3a66d05f698dcb363</citedby><cites>FETCH-LOGICAL-c4981-a62c0c4e825dc2db86b0a6156649d8dfaec31e469ab6e32d3a66d05f698dcb363</cites><orcidid>0000-0002-7640-8833 ; 0000-0001-9701-3331 ; 0000-0002-8494-4978 ; 0000-0003-1094-3363</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmnfr.202100606$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmnfr.202100606$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34661340$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.inrae.fr/hal-03812949$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>González‐Domínguez, Raúl</creatorcontrib><creatorcontrib>Castellano‐Escuder, Pol</creatorcontrib><creatorcontrib>Carmona, Francisco</creatorcontrib><creatorcontrib>Lefèvre‐Arbogast, Sophie</creatorcontrib><creatorcontrib>Low, Dorrain Y.</creatorcontrib><creatorcontrib>Du Preez, Andrea</creatorcontrib><creatorcontrib>Ruigrok, Silvie R.</creatorcontrib><creatorcontrib>Manach, Claudine</creatorcontrib><creatorcontrib>Urpi‐Sarda, Mireia</creatorcontrib><creatorcontrib>Korosi, Aniko</creatorcontrib><creatorcontrib>Lucassen, Paul J.</creatorcontrib><creatorcontrib>Aigner, Ludwig</creatorcontrib><creatorcontrib>Pallàs, Mercè</creatorcontrib><creatorcontrib>Thuret, Sandrine</creatorcontrib><creatorcontrib>Samieri, Cécilia</creatorcontrib><creatorcontrib>Sánchez‐Pla, Alex</creatorcontrib><creatorcontrib>Andres‐Lacueva, Cristina</creatorcontrib><title>Food and Microbiota Metabolites Associate with Cognitive Decline in Older Subjects: A 12‐Year Prospective Study</title><title>Molecular nutrition & food research</title><addtitle>Mol Nutr Food Res</addtitle><description>Scope
Diet is considered an important modulator of cognitive decline and dementia, but the available evidence is, however, still fragmented and often inconsistent.
Methods and Results
The article studies the long‐term prospective Three‐City Cohort, which consists of two separate nested case‐control sample sets from different geographic regions (Bordeaux, n = 418; Dijon, n = 424). Cognitive decline is evaluated through five neuropsychological tests (Mini‐Mental State Examination, Benton Visual Retention Test, Isaac's Set Test, Trail‐Making Test part A, and Trail‐Making Test part B). The food‐related and microbiota‐derived circulating metabolome is studied in participants free of dementia at baseline, by subjecting serum samples to large‐scale quantitative metabolomics analysis. A protective association is found between metabolites derived from cocoa, coffee, mushrooms, red wine, the microbial metabolism of polyphenol‐rich foods, and cognitive decline, as well as a negative association with metabolites related to unhealthy dietary components, such as artificial sweeteners and alcohol.
Conclusion
These results provide insight into the early metabolic events that are associated with the later risk to develop cognitive decline within the crosstalk between diet, gut microbiota and the endogenous metabolism, which can help identify potential targets for preventive and therapeutic strategies to preserve cognitive health.
A large‐scale quantitative metabolomics platform is employed to obtain a deeper insight into the role of diet in the early onset of cognitive decline. Strong evidence supports a protective association between metabolites derived from cocoa, coffee, mushrooms, red wine, the microbial metabolism of polyphenol‐rich foods and cognitive decline. The article also finds a negative association with metabolites related to unhealthy dietary components, such as artificial sweeteners and alcohol.</description><subject>Aged</subject><subject>Cocoa</subject><subject>Coffee</subject><subject>Cognitive ability</subject><subject>cognitive decline</subject><subject>Cognitive Dysfunction - etiology</subject><subject>Crosstalk</subject><subject>Dementia</subject><subject>Dementia disorders</subject><subject>Diet</subject><subject>Food</subject><subject>Food and Nutrition</subject><subject>food metabolome</subject><subject>Gastrointestinal Microbiome</subject><subject>gut microbiota</subject><subject>Humans</subject><subject>Intestinal microflora</subject><subject>Life Sciences</subject><subject>Metabolism</subject><subject>Metabolites</subject><subject>Metabolomics</subject><subject>Microbiota</subject><subject>Microorganisms</subject><subject>Prospective Studies</subject><subject>Sweeteners</subject><subject>Target recognition</subject><subject>Wines</subject><issn>1613-4125</issn><issn>1613-4133</issn><issn>1613-4133</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><recordid>eNqFkcFuEzEQhlcIREvhyhFZ4gKHBI_tdXe5VFFoKFJCEYUDJ8trTxpHm3Vqe1Pl1kfgGXkSHKVE0Asn2zPf_4_tvyheAh0CpezdqpuHIaMsHySVj4pjkMAHAjh_fNiz8qh4FuOSUg5M8KfFERcytwQ9Lm4m3luiO0tmzgTfOJ80mWHSjW9dwkhGMXrjdEJy69KCjP1155LbIPmApnUdEteRy9ZiIFd9s0ST4nsyIsB-3f38gTqQL8HHdS7vJFept9vnxZO5biO-uF9Piu-T82_ji8H08uOn8Wg6MKKuYKAlM9QIrFhpDbNNJRuqJZRSitpWdq7RcEAha91I5MxyLaWl5VzWlTUNl_ykONv7rvtmhdZgl4Ju1Tq4lQ5b5bVT_3Y6t1DXfqMAxGlZcpod3u4dFg90F6Op2tUor4DVot5AZt_cTwv-pseY1MpFg22rO_R9VKysOKeyYnVGXz9Al74PXf4LxSRUjPFTYJka7qmcSowB54cbAFW76NUuenWIPgte_f3eA_4n6wyIPXDrWtz-x07NPk--CgDgvwGB27rI</recordid><startdate>202112</startdate><enddate>202112</enddate><creator>González‐Domínguez, Raúl</creator><creator>Castellano‐Escuder, Pol</creator><creator>Carmona, Francisco</creator><creator>Lefèvre‐Arbogast, Sophie</creator><creator>Low, Dorrain Y.</creator><creator>Du Preez, Andrea</creator><creator>Ruigrok, Silvie R.</creator><creator>Manach, Claudine</creator><creator>Urpi‐Sarda, Mireia</creator><creator>Korosi, Aniko</creator><creator>Lucassen, Paul J.</creator><creator>Aigner, Ludwig</creator><creator>Pallàs, Mercè</creator><creator>Thuret, Sandrine</creator><creator>Samieri, Cécilia</creator><creator>Sánchez‐Pla, Alex</creator><creator>Andres‐Lacueva, Cristina</creator><general>Wiley Subscription Services, Inc</general><general>Wiley-VCH Verlag</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QP</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope><scope>1XC</scope><scope>VOOES</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-7640-8833</orcidid><orcidid>https://orcid.org/0000-0001-9701-3331</orcidid><orcidid>https://orcid.org/0000-0002-8494-4978</orcidid><orcidid>https://orcid.org/0000-0003-1094-3363</orcidid></search><sort><creationdate>202112</creationdate><title>Food and Microbiota Metabolites Associate with Cognitive Decline in Older Subjects: A 12‐Year Prospective Study</title><author>González‐Domínguez, Raúl ; Castellano‐Escuder, Pol ; Carmona, Francisco ; Lefèvre‐Arbogast, Sophie ; Low, Dorrain Y. ; Du Preez, Andrea ; Ruigrok, Silvie R. ; Manach, Claudine ; Urpi‐Sarda, Mireia ; Korosi, Aniko ; Lucassen, Paul J. ; Aigner, Ludwig ; Pallàs, Mercè ; Thuret, Sandrine ; Samieri, Cécilia ; Sánchez‐Pla, Alex ; Andres‐Lacueva, Cristina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4981-a62c0c4e825dc2db86b0a6156649d8dfaec31e469ab6e32d3a66d05f698dcb363</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Aged</topic><topic>Cocoa</topic><topic>Coffee</topic><topic>Cognitive ability</topic><topic>cognitive decline</topic><topic>Cognitive Dysfunction - etiology</topic><topic>Crosstalk</topic><topic>Dementia</topic><topic>Dementia disorders</topic><topic>Diet</topic><topic>Food</topic><topic>Food and Nutrition</topic><topic>food metabolome</topic><topic>Gastrointestinal Microbiome</topic><topic>gut microbiota</topic><topic>Humans</topic><topic>Intestinal microflora</topic><topic>Life Sciences</topic><topic>Metabolism</topic><topic>Metabolites</topic><topic>Metabolomics</topic><topic>Microbiota</topic><topic>Microorganisms</topic><topic>Prospective Studies</topic><topic>Sweeteners</topic><topic>Target recognition</topic><topic>Wines</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>González‐Domínguez, Raúl</creatorcontrib><creatorcontrib>Castellano‐Escuder, Pol</creatorcontrib><creatorcontrib>Carmona, Francisco</creatorcontrib><creatorcontrib>Lefèvre‐Arbogast, Sophie</creatorcontrib><creatorcontrib>Low, Dorrain Y.</creatorcontrib><creatorcontrib>Du Preez, Andrea</creatorcontrib><creatorcontrib>Ruigrok, Silvie R.</creatorcontrib><creatorcontrib>Manach, Claudine</creatorcontrib><creatorcontrib>Urpi‐Sarda, Mireia</creatorcontrib><creatorcontrib>Korosi, Aniko</creatorcontrib><creatorcontrib>Lucassen, Paul J.</creatorcontrib><creatorcontrib>Aigner, Ludwig</creatorcontrib><creatorcontrib>Pallàs, Mercè</creatorcontrib><creatorcontrib>Thuret, Sandrine</creatorcontrib><creatorcontrib>Samieri, Cécilia</creatorcontrib><creatorcontrib>Sánchez‐Pla, Alex</creatorcontrib><creatorcontrib>Andres‐Lacueva, Cristina</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Wiley Free Content</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Molecular nutrition & food research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>González‐Domínguez, Raúl</au><au>Castellano‐Escuder, Pol</au><au>Carmona, Francisco</au><au>Lefèvre‐Arbogast, Sophie</au><au>Low, Dorrain Y.</au><au>Du Preez, Andrea</au><au>Ruigrok, Silvie R.</au><au>Manach, Claudine</au><au>Urpi‐Sarda, Mireia</au><au>Korosi, Aniko</au><au>Lucassen, Paul J.</au><au>Aigner, Ludwig</au><au>Pallàs, Mercè</au><au>Thuret, Sandrine</au><au>Samieri, Cécilia</au><au>Sánchez‐Pla, Alex</au><au>Andres‐Lacueva, Cristina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Food and Microbiota Metabolites Associate with Cognitive Decline in Older Subjects: A 12‐Year Prospective Study</atitle><jtitle>Molecular nutrition & food research</jtitle><addtitle>Mol Nutr Food Res</addtitle><date>2021-12</date><risdate>2021</risdate><volume>65</volume><issue>23</issue><spage>e2100606</spage><epage>n/a</epage><pages>e2100606-n/a</pages><issn>1613-4125</issn><issn>1613-4133</issn><eissn>1613-4133</eissn><abstract>Scope
Diet is considered an important modulator of cognitive decline and dementia, but the available evidence is, however, still fragmented and often inconsistent.
Methods and Results
The article studies the long‐term prospective Three‐City Cohort, which consists of two separate nested case‐control sample sets from different geographic regions (Bordeaux, n = 418; Dijon, n = 424). Cognitive decline is evaluated through five neuropsychological tests (Mini‐Mental State Examination, Benton Visual Retention Test, Isaac's Set Test, Trail‐Making Test part A, and Trail‐Making Test part B). The food‐related and microbiota‐derived circulating metabolome is studied in participants free of dementia at baseline, by subjecting serum samples to large‐scale quantitative metabolomics analysis. A protective association is found between metabolites derived from cocoa, coffee, mushrooms, red wine, the microbial metabolism of polyphenol‐rich foods, and cognitive decline, as well as a negative association with metabolites related to unhealthy dietary components, such as artificial sweeteners and alcohol.
Conclusion
These results provide insight into the early metabolic events that are associated with the later risk to develop cognitive decline within the crosstalk between diet, gut microbiota and the endogenous metabolism, which can help identify potential targets for preventive and therapeutic strategies to preserve cognitive health.
A large‐scale quantitative metabolomics platform is employed to obtain a deeper insight into the role of diet in the early onset of cognitive decline. Strong evidence supports a protective association between metabolites derived from cocoa, coffee, mushrooms, red wine, the microbial metabolism of polyphenol‐rich foods and cognitive decline. The article also finds a negative association with metabolites related to unhealthy dietary components, such as artificial sweeteners and alcohol.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>34661340</pmid><doi>10.1002/mnfr.202100606</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-7640-8833</orcidid><orcidid>https://orcid.org/0000-0001-9701-3331</orcidid><orcidid>https://orcid.org/0000-0002-8494-4978</orcidid><orcidid>https://orcid.org/0000-0003-1094-3363</orcidid><oa>free_for_read</oa></addata></record> |
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| issn | 1613-4125 1613-4133 1613-4133 |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | Aged Cocoa Coffee Cognitive ability cognitive decline Cognitive Dysfunction - etiology Crosstalk Dementia Dementia disorders Diet Food Food and Nutrition food metabolome Gastrointestinal Microbiome gut microbiota Humans Intestinal microflora Life Sciences Metabolism Metabolites Metabolomics Microbiota Microorganisms Prospective Studies Sweeteners Target recognition Wines |
| title | Food and Microbiota Metabolites Associate with Cognitive Decline in Older Subjects: A 12‐Year Prospective Study |
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