Identification and classification of host cell proteins during biopharmaceutical process development

As significant improvements in volumetric antibody productivity have been achieved by advances in upstream processing over the last decade, and harvest material has become progressively more difficult to recover with these intensified upstream operations, the segregation of upstream and downstream p...

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Veröffentlicht in:	Biotechnology progress 2022-01, Vol.38 (1), p.e3224-n/a
Hauptverfasser:	Wilson, Louisa J., Lewis, Will, Kucia‐Tran, Richard, Bracewell, Daniel G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Biological Products Biopharmaceuticals Bioreactors Cell culture CHO Cells Cricetinae Cricetulus downstream processing host cell proteins Immunoglobulin G Mass spectrometry Mass Spectrometry - methods Mass spectroscopy Monoclonal antibodies Optimization Peptides product quality Protein A Protein purification Proteins Purification Quality management Upstream upstream processing
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