Oxidative damage biomarkers and antioxidant enzymes in saliva of patients with peri-implant diseases
Objectives 8-hydroxydeoxyguanosine (8-OHdG) and Malondialdehyde (MDA) are commonly used as markers to evaluate oxidative DNA and Lipid damage in disorders including chronic inflammatory diseases. Superoxide dismutase (SOD) and glutathione peroxidase (GPx) protect tissues against oxidative injury fro...
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| description | Objectives
8-hydroxydeoxyguanosine (8-OHdG) and Malondialdehyde (MDA) are commonly used as markers to evaluate oxidative DNA and Lipid damage in disorders including chronic inflammatory diseases. Superoxide dismutase (SOD) and glutathione peroxidase (GPx) protect tissues against oxidative injury from free oxygen radicals generated by various metabolic processes. The aim of this study was to evaluate 8-OHdG and MDA levels, and SOD and GPx activities in whole saliva of patients with peri-implant diseases.
Materials and methods
A cross-sectional study was conducted on a sum of 60 age gender balanced; peri-implantitis (
n
= 20), peri-mucositis (
n
= 20) and healthy (
n
= 20) individuals. Unstimulated whole saliva samples were collected and to determine the clinical condition of each subject; the plaque index (PI), gingival index (GI), peri-implant probing pocket depth (PIPD), peri-implant presence of bleeding on probing (BOP) (with/without suppuration) and radiographic signs of crestal bone loss (BL) were measured. The salivary 8-OHdG level was measured using the ELISA method. SOD, GPx activities and MDA levels were determined spectrophotometrically.
Results
A total of 60 individuals had evaluations of 318 implants. In comparison to the peri-mucositis and peri-implantitis groups, the healthy group had significantly lower PI and GI scores (
p
|
| doi_str_mv | 10.1186/s40729-024-00562-x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11473456</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3116338851</sourcerecordid><originalsourceid>FETCH-LOGICAL-c356t-98f43b4f706feb79684f51dab3dc893ee5bcf25e78e14974a4a000275c78a0bc3</originalsourceid><addsrcrecordid>eNp9kU9P3DAQxS3UqiDKF-gBWeqll4D_JvapqlCBSkhc4Gw5yWQxTeLUk90ufHq8LAXKgYNlS_ObN_P8CPnC2RHnpjxGxSphCyZUwZguRbHeIXuCW1MoJtWHV-9dcoB4yxjjpVRC8E9kV1rFWMnVHmkv16H1c1gBbf3gF0DrEAeffkNC6sc2nznEDTPOFMb7uwGQhpGi78PK09jRKXfDOCP9G-YbOkEKRRimfsO3AcEj4GfysfM9wsHTvU-uT39enZwXF5dnv05-XBSN1OVcWNMpWauuYmUHdWVLozrNW1_LtjFWAui66YSGygBXtlJe-exKVLqpjGd1I_fJ963utKwHaJu8VvK9m1LIju5c9MH9XxnDjVvEleNcVVLpMit8e1JI8c8ScHZDwAb6bAfiEp3k-ROlMZpn9Osb9DYu05j9PVJKWytEpsSWalJETNA9b8OZ2wTptkG6HKR7DNKtc9Phax_PLf9iy4DcAphL4wLSy-x3ZB8AeAqrew</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3116459922</pqid></control><display><type>article</type><title>Oxidative damage biomarkers and antioxidant enzymes in saliva of patients with peri-implant diseases</title><source>Open Access: PubMed Central</source><source>MEDLINE</source><source>SpringerOpen (Open Access)</source><source>EZB Electronic Journals Library</source><source>Springer Online Journals - JUSTICE</source><source>PubMed Central Open Access</source><creator>Özkan Karasu, Yerda ; Maden, Oğuzhan ; Çanakçı, Cenk Fatih</creator><creatorcontrib>Özkan Karasu, Yerda ; Maden, Oğuzhan ; Çanakçı, Cenk Fatih</creatorcontrib><description><![CDATA[Objectives
8-hydroxydeoxyguanosine (8-OHdG) and Malondialdehyde (MDA) are commonly used as markers to evaluate oxidative DNA and Lipid damage in disorders including chronic inflammatory diseases. Superoxide dismutase (SOD) and glutathione peroxidase (GPx) protect tissues against oxidative injury from free oxygen radicals generated by various metabolic processes. The aim of this study was to evaluate 8-OHdG and MDA levels, and SOD and GPx activities in whole saliva of patients with peri-implant diseases.
Materials and methods
A cross-sectional study was conducted on a sum of 60 age gender balanced; peri-implantitis (
n
= 20), peri-mucositis (
n
= 20) and healthy (
n
= 20) individuals. Unstimulated whole saliva samples were collected and to determine the clinical condition of each subject; the plaque index (PI), gingival index (GI), peri-implant probing pocket depth (PIPD), peri-implant presence of bleeding on probing (BOP) (with/without suppuration) and radiographic signs of crestal bone loss (BL) were measured. The salivary 8-OHdG level was measured using the ELISA method. SOD, GPx activities and MDA levels were determined spectrophotometrically.
Results
A total of 60 individuals had evaluations of 318 implants. In comparison to the peri-mucositis and peri-implantitis groups, the healthy group had significantly lower PI and GI scores (
p
< 0.001). The PIPD value differed amongst the groups, with the peri-implantitis group having the highest value (
p
< 0.001). Compared to the peri-mucositis and control groups, the peri-implantitis group had a significantly higher BL score (
p
< 0.001 and
p
< 0.001, respectively). The peri-implantitis group showed a significantly higher 8-OHdG level (
p
< 0.001;
p
< 0.001 respectively) than the peri-mucositis and control groups. Compared to the peri-mucositis and control groups, the peri-implantitis group had a significantly higher MDA level (
p
< 0.001 and
p
< 0.001, respectively). The peri-implantitis group had a significantly higher SOD level (
p
< 0.001 and
p
< 0.001, respectively) in comparison to the peri-mucositis and control groups. There was no significant difference in GPx levels between the peri-mucositis and control groups (
p
> 0.05), while the peri-implantitis group had significantly lower GPx levels than the peri-mucositis and control groups (
p
< 0.001 and
p
< 0.001, respectively).
Conclusions
Elevated levels of oxidative stress in saliva may indicate the onset of pathological bone loss surrounding the implant and may be an indication of peri-implantitis.
Clinical relevance
In peri-implant diseases, changes may occur in the levels of 8-OHdG, MDA, SOD and GPx in saliva, which may lead to a deterioration in the oxidant/antioxidant balance.]]></description><identifier>ISSN: 2198-4034</identifier><identifier>EISSN: 2198-4034</identifier><identifier>DOI: 10.1186/s40729-024-00562-x</identifier><identifier>PMID: 39400614</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>8-Hydroxy-2'-Deoxyguanosine - metabolism ; Adult ; Antioxidants ; Antioxidants - metabolism ; Biomarkers ; Biomarkers - analysis ; Biomarkers - metabolism ; Cross-Sectional Studies ; Damage assessment ; Dental Plaque Index ; Dentistry ; Deoxyguanosine - analogs & derivatives ; Deoxyguanosine - analysis ; Deoxyguanosine - metabolism ; Female ; Glutathione ; Glutathione Peroxidase - analysis ; Glutathione Peroxidase - metabolism ; Humans ; Lipids ; Male ; Malondialdehyde - metabolism ; Medicine ; Middle Aged ; Mucositis ; Oxidative Stress - physiology ; Oxidizing agents ; Peri-Implantitis - diagnosis ; Peri-Implantitis - enzymology ; Peri-Implantitis - metabolism ; Periodontal Index ; Peroxidase ; Saliva ; Saliva - chemistry ; Saliva - enzymology ; Spectrophotometry ; Stomatitis - diagnosis ; Stomatitis - enzymology ; Stomatitis - metabolism ; Superoxide dismutase ; Superoxide Dismutase - analysis ; Superoxide Dismutase - metabolism ; Transplants & implants</subject><ispartof>International journal of implant dentistry, 2024-10, Vol.10 (1), p.43, Article 43</ispartof><rights>The Author(s) 2024</rights><rights>2024. The Author(s).</rights><rights>The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s) 2024 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c356t-98f43b4f706feb79684f51dab3dc893ee5bcf25e78e14974a4a000275c78a0bc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11473456/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11473456/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,41096,41464,42165,42533,51294,51551,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39400614$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Özkan Karasu, Yerda</creatorcontrib><creatorcontrib>Maden, Oğuzhan</creatorcontrib><creatorcontrib>Çanakçı, Cenk Fatih</creatorcontrib><title>Oxidative damage biomarkers and antioxidant enzymes in saliva of patients with peri-implant diseases</title><title>International journal of implant dentistry</title><addtitle>Int J Implant Dent</addtitle><addtitle>Int J Implant Dent</addtitle><description><![CDATA[Objectives
8-hydroxydeoxyguanosine (8-OHdG) and Malondialdehyde (MDA) are commonly used as markers to evaluate oxidative DNA and Lipid damage in disorders including chronic inflammatory diseases. Superoxide dismutase (SOD) and glutathione peroxidase (GPx) protect tissues against oxidative injury from free oxygen radicals generated by various metabolic processes. The aim of this study was to evaluate 8-OHdG and MDA levels, and SOD and GPx activities in whole saliva of patients with peri-implant diseases.
Materials and methods
A cross-sectional study was conducted on a sum of 60 age gender balanced; peri-implantitis (
n
= 20), peri-mucositis (
n
= 20) and healthy (
n
= 20) individuals. Unstimulated whole saliva samples were collected and to determine the clinical condition of each subject; the plaque index (PI), gingival index (GI), peri-implant probing pocket depth (PIPD), peri-implant presence of bleeding on probing (BOP) (with/without suppuration) and radiographic signs of crestal bone loss (BL) were measured. The salivary 8-OHdG level was measured using the ELISA method. SOD, GPx activities and MDA levels were determined spectrophotometrically.
Results
A total of 60 individuals had evaluations of 318 implants. In comparison to the peri-mucositis and peri-implantitis groups, the healthy group had significantly lower PI and GI scores (
p
< 0.001). The PIPD value differed amongst the groups, with the peri-implantitis group having the highest value (
p
< 0.001). Compared to the peri-mucositis and control groups, the peri-implantitis group had a significantly higher BL score (
p
< 0.001 and
p
< 0.001, respectively). The peri-implantitis group showed a significantly higher 8-OHdG level (
p
< 0.001;
p
< 0.001 respectively) than the peri-mucositis and control groups. Compared to the peri-mucositis and control groups, the peri-implantitis group had a significantly higher MDA level (
p
< 0.001 and
p
< 0.001, respectively). The peri-implantitis group had a significantly higher SOD level (
p
< 0.001 and
p
< 0.001, respectively) in comparison to the peri-mucositis and control groups. There was no significant difference in GPx levels between the peri-mucositis and control groups (
p
> 0.05), while the peri-implantitis group had significantly lower GPx levels than the peri-mucositis and control groups (
p
< 0.001 and
p
< 0.001, respectively).
Conclusions
Elevated levels of oxidative stress in saliva may indicate the onset of pathological bone loss surrounding the implant and may be an indication of peri-implantitis.
Clinical relevance
In peri-implant diseases, changes may occur in the levels of 8-OHdG, MDA, SOD and GPx in saliva, which may lead to a deterioration in the oxidant/antioxidant balance.]]></description><subject>8-Hydroxy-2'-Deoxyguanosine - metabolism</subject><subject>Adult</subject><subject>Antioxidants</subject><subject>Antioxidants - metabolism</subject><subject>Biomarkers</subject><subject>Biomarkers - analysis</subject><subject>Biomarkers - metabolism</subject><subject>Cross-Sectional Studies</subject><subject>Damage assessment</subject><subject>Dental Plaque Index</subject><subject>Dentistry</subject><subject>Deoxyguanosine - analogs & derivatives</subject><subject>Deoxyguanosine - analysis</subject><subject>Deoxyguanosine - metabolism</subject><subject>Female</subject><subject>Glutathione</subject><subject>Glutathione Peroxidase - analysis</subject><subject>Glutathione Peroxidase - metabolism</subject><subject>Humans</subject><subject>Lipids</subject><subject>Male</subject><subject>Malondialdehyde - metabolism</subject><subject>Medicine</subject><subject>Middle Aged</subject><subject>Mucositis</subject><subject>Oxidative Stress - physiology</subject><subject>Oxidizing agents</subject><subject>Peri-Implantitis - diagnosis</subject><subject>Peri-Implantitis - enzymology</subject><subject>Peri-Implantitis - metabolism</subject><subject>Periodontal Index</subject><subject>Peroxidase</subject><subject>Saliva</subject><subject>Saliva - chemistry</subject><subject>Saliva - enzymology</subject><subject>Spectrophotometry</subject><subject>Stomatitis - diagnosis</subject><subject>Stomatitis - enzymology</subject><subject>Stomatitis - metabolism</subject><subject>Superoxide dismutase</subject><subject>Superoxide Dismutase - analysis</subject><subject>Superoxide Dismutase - metabolism</subject><subject>Transplants & implants</subject><issn>2198-4034</issn><issn>2198-4034</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kU9P3DAQxS3UqiDKF-gBWeqll4D_JvapqlCBSkhc4Gw5yWQxTeLUk90ufHq8LAXKgYNlS_ObN_P8CPnC2RHnpjxGxSphCyZUwZguRbHeIXuCW1MoJtWHV-9dcoB4yxjjpVRC8E9kV1rFWMnVHmkv16H1c1gBbf3gF0DrEAeffkNC6sc2nznEDTPOFMb7uwGQhpGi78PK09jRKXfDOCP9G-YbOkEKRRimfsO3AcEj4GfysfM9wsHTvU-uT39enZwXF5dnv05-XBSN1OVcWNMpWauuYmUHdWVLozrNW1_LtjFWAui66YSGygBXtlJe-exKVLqpjGd1I_fJ963utKwHaJu8VvK9m1LIju5c9MH9XxnDjVvEleNcVVLpMit8e1JI8c8ScHZDwAb6bAfiEp3k-ROlMZpn9Osb9DYu05j9PVJKWytEpsSWalJETNA9b8OZ2wTptkG6HKR7DNKtc9Phax_PLf9iy4DcAphL4wLSy-x3ZB8AeAqrew</recordid><startdate>20241014</startdate><enddate>20241014</enddate><creator>Özkan Karasu, Yerda</creator><creator>Maden, Oğuzhan</creator><creator>Çanakçı, Cenk Fatih</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FE</scope><scope>8FG</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>M0S</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20241014</creationdate><title>Oxidative damage biomarkers and antioxidant enzymes in saliva of patients with peri-implant diseases</title><author>Özkan Karasu, Yerda ; Maden, Oğuzhan ; Çanakçı, Cenk Fatih</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-98f43b4f706feb79684f51dab3dc893ee5bcf25e78e14974a4a000275c78a0bc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>8-Hydroxy-2'-Deoxyguanosine - metabolism</topic><topic>Adult</topic><topic>Antioxidants</topic><topic>Antioxidants - metabolism</topic><topic>Biomarkers</topic><topic>Biomarkers - analysis</topic><topic>Biomarkers - metabolism</topic><topic>Cross-Sectional Studies</topic><topic>Damage assessment</topic><topic>Dental Plaque Index</topic><topic>Dentistry</topic><topic>Deoxyguanosine - analogs & derivatives</topic><topic>Deoxyguanosine - analysis</topic><topic>Deoxyguanosine - metabolism</topic><topic>Female</topic><topic>Glutathione</topic><topic>Glutathione Peroxidase - analysis</topic><topic>Glutathione Peroxidase - metabolism</topic><topic>Humans</topic><topic>Lipids</topic><topic>Male</topic><topic>Malondialdehyde - metabolism</topic><topic>Medicine</topic><topic>Middle Aged</topic><topic>Mucositis</topic><topic>Oxidative Stress - physiology</topic><topic>Oxidizing agents</topic><topic>Peri-Implantitis - diagnosis</topic><topic>Peri-Implantitis - enzymology</topic><topic>Peri-Implantitis - metabolism</topic><topic>Periodontal Index</topic><topic>Peroxidase</topic><topic>Saliva</topic><topic>Saliva - chemistry</topic><topic>Saliva - enzymology</topic><topic>Spectrophotometry</topic><topic>Stomatitis - diagnosis</topic><topic>Stomatitis - enzymology</topic><topic>Stomatitis - metabolism</topic><topic>Superoxide dismutase</topic><topic>Superoxide Dismutase - analysis</topic><topic>Superoxide Dismutase - metabolism</topic><topic>Transplants & implants</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Özkan Karasu, Yerda</creatorcontrib><creatorcontrib>Maden, Oğuzhan</creatorcontrib><creatorcontrib>Çanakçı, Cenk Fatih</creatorcontrib><collection>SpringerOpen (Open Access)</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection (Proquest)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Materials Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of implant dentistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Özkan Karasu, Yerda</au><au>Maden, Oğuzhan</au><au>Çanakçı, Cenk Fatih</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oxidative damage biomarkers and antioxidant enzymes in saliva of patients with peri-implant diseases</atitle><jtitle>International journal of implant dentistry</jtitle><stitle>Int J Implant Dent</stitle><addtitle>Int J Implant Dent</addtitle><date>2024-10-14</date><risdate>2024</risdate><volume>10</volume><issue>1</issue><spage>43</spage><pages>43-</pages><artnum>43</artnum><issn>2198-4034</issn><eissn>2198-4034</eissn><abstract><![CDATA[Objectives
8-hydroxydeoxyguanosine (8-OHdG) and Malondialdehyde (MDA) are commonly used as markers to evaluate oxidative DNA and Lipid damage in disorders including chronic inflammatory diseases. Superoxide dismutase (SOD) and glutathione peroxidase (GPx) protect tissues against oxidative injury from free oxygen radicals generated by various metabolic processes. The aim of this study was to evaluate 8-OHdG and MDA levels, and SOD and GPx activities in whole saliva of patients with peri-implant diseases.
Materials and methods
A cross-sectional study was conducted on a sum of 60 age gender balanced; peri-implantitis (
n
= 20), peri-mucositis (
n
= 20) and healthy (
n
= 20) individuals. Unstimulated whole saliva samples were collected and to determine the clinical condition of each subject; the plaque index (PI), gingival index (GI), peri-implant probing pocket depth (PIPD), peri-implant presence of bleeding on probing (BOP) (with/without suppuration) and radiographic signs of crestal bone loss (BL) were measured. The salivary 8-OHdG level was measured using the ELISA method. SOD, GPx activities and MDA levels were determined spectrophotometrically.
Results
A total of 60 individuals had evaluations of 318 implants. In comparison to the peri-mucositis and peri-implantitis groups, the healthy group had significantly lower PI and GI scores (
p
< 0.001). The PIPD value differed amongst the groups, with the peri-implantitis group having the highest value (
p
< 0.001). Compared to the peri-mucositis and control groups, the peri-implantitis group had a significantly higher BL score (
p
< 0.001 and
p
< 0.001, respectively). The peri-implantitis group showed a significantly higher 8-OHdG level (
p
< 0.001;
p
< 0.001 respectively) than the peri-mucositis and control groups. Compared to the peri-mucositis and control groups, the peri-implantitis group had a significantly higher MDA level (
p
< 0.001 and
p
< 0.001, respectively). The peri-implantitis group had a significantly higher SOD level (
p
< 0.001 and
p
< 0.001, respectively) in comparison to the peri-mucositis and control groups. There was no significant difference in GPx levels between the peri-mucositis and control groups (
p
> 0.05), while the peri-implantitis group had significantly lower GPx levels than the peri-mucositis and control groups (
p
< 0.001 and
p
< 0.001, respectively).
Conclusions
Elevated levels of oxidative stress in saliva may indicate the onset of pathological bone loss surrounding the implant and may be an indication of peri-implantitis.
Clinical relevance
In peri-implant diseases, changes may occur in the levels of 8-OHdG, MDA, SOD and GPx in saliva, which may lead to a deterioration in the oxidant/antioxidant balance.]]></abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>39400614</pmid><doi>10.1186/s40729-024-00562-x</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2198-4034 |
| ispartof | International journal of implant dentistry, 2024-10, Vol.10 (1), p.43, Article 43 |
| issn | 2198-4034 2198-4034 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11473456 |
| source | Open Access: PubMed Central; MEDLINE; SpringerOpen (Open Access); EZB Electronic Journals Library; Springer Online Journals - JUSTICE; PubMed Central Open Access |
| subjects | 8-Hydroxy-2'-Deoxyguanosine - metabolism Adult Antioxidants Antioxidants - metabolism Biomarkers Biomarkers - analysis Biomarkers - metabolism Cross-Sectional Studies Damage assessment Dental Plaque Index Dentistry Deoxyguanosine - analogs & derivatives Deoxyguanosine - analysis Deoxyguanosine - metabolism Female Glutathione Glutathione Peroxidase - analysis Glutathione Peroxidase - metabolism Humans Lipids Male Malondialdehyde - metabolism Medicine Middle Aged Mucositis Oxidative Stress - physiology Oxidizing agents Peri-Implantitis - diagnosis Peri-Implantitis - enzymology Peri-Implantitis - metabolism Periodontal Index Peroxidase Saliva Saliva - chemistry Saliva - enzymology Spectrophotometry Stomatitis - diagnosis Stomatitis - enzymology Stomatitis - metabolism Superoxide dismutase Superoxide Dismutase - analysis Superoxide Dismutase - metabolism Transplants & implants |
| title | Oxidative damage biomarkers and antioxidant enzymes in saliva of patients with peri-implant diseases |
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