Lactate supports Treg function and immune balance via MGAT1 effects on N-glycosylation in the mitochondria

Current research reports that lactate affects Treg metabolism, although the precise mechanism has only been partially elucidated. In this study, we presented evidence demonstrating that elevated lactate levels enhanced cell proliferation, suppressive capabilities, and oxidative phosphorylation (OXPH...

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Veröffentlicht in:	The Journal of clinical investigation 2024-10, Vol.134 (20), p.1-18
Hauptverfasser:	Zhou, Jinren, Gu, Jian, Qian, Qufei, Zhang, Yigang, Huang, Tianning, Li, Xiangyu, Liu, Zhuoqun, Shao, Qing, Liang, Yuan, Qiao, Lei, Xu, Xiaozhang, Chen, Qiuyang, Xu, Zibo, Li, Yu, Gao, Ji, Pan, Yufeng, Wang, Yiming, O'Connor, Roddy, Hippen, Keli L, Lu, Ling, Blazar, Bruce R
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis B cells Cell growth Cell proliferation Cytokines Glycosylation Graft versus host disease Graft-versus-host reaction Health aspects Homeostasis Hypoxia Immune system International economic relations Intracellular Lactates Lactic acid Lymphocytes T Medical research Medicine, Experimental Metabolism Mitochondria N-Acetylglucosinyldiphosphodolichol N-acetylglucosaminyltransferase Oxidative phosphorylation Phosphorylation Physiological aspects Proteins Proteomics Scientific equipment and supplies industry Sodium T cells Transferases Translocase Xenografts
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