A regulatory loop of JAK/STAT signalling and its downstream targets represses cell fate conversion and maintains male germline stem cell niche homeostasis
A specialised microenvironment, termed niche, provides extrinsic signals for the maintenance of residential stem cells. However, how residential stem cells maintain niche homeostasis and whether stromal niche cells could convert their fate into stem cells to replenish lost stem cells upon systemic s...
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| Veröffentlicht in: | Cell proliferation 2024-10, Vol.57 (10), p.e13648-n/a |
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| creator | Kong, Ruiyan Zhao, Hang Li, Juan Ma, Yankun Li, Ningfang Shi, Lin Li, Zhouhua |
| description | A specialised microenvironment, termed niche, provides extrinsic signals for the maintenance of residential stem cells. However, how residential stem cells maintain niche homeostasis and whether stromal niche cells could convert their fate into stem cells to replenish lost stem cells upon systemic stem cell loss remain largely unknown. Here, through systemic identification of JAK/STAT downstream targets in adult Drosophila testis, we show that Escargot (Esg), a member of the Snail family of transcriptional factors, is a putative JAK/STAT downstream target. esg is intrinsically required in cyst stem cells (CySCs) but not in germline stem cells (GSCs). esg depletion in CySCs results in CySC loss due to differentiation and non‐cell autonomous GSC loss. Interestingly, hub cells are gradually lost by delaminating from the hub and converting into CySCs in esg‐defective testes. Mechanistically, esg directly represses the expression of socs36E, the well‐known downstream target and negative regulator of JAK/STAT signalling. Finally, further depletion of socs36E completely rescues the defects observed in esg‐defective testes. Collectively, JAK/STAT target Esg suppresses SOCS36E to maintain CySC fate and repress niche cell conversion. Thus, our work uncovers a regulatory loop between JAK/STAT signalling and its downstream targets in controlling testicular niche homeostasis under physiological conditions.
Esg suppresses the expression of SOCS36E, the downstream target and negative regulator of JAK/STAT signalling. Loss of esg leads to systemic CySC loss. Once the hub senses the systemic loss of CySCs, some hub cells are delaminated from the hub and converted into functional CySCs to replace the lost CySCs. |
| doi_str_mv | 10.1111/cpr.13648 |
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Esg suppresses the expression of SOCS36E, the downstream target and negative regulator of JAK/STAT signalling. Loss of esg leads to systemic CySC loss. Once the hub senses the systemic loss of CySCs, some hub cells are delaminated from the hub and converted into functional CySCs to replace the lost CySCs.</description><identifier>ISSN: 0960-7722</identifier><identifier>ISSN: 1365-2184</identifier><identifier>EISSN: 1365-2184</identifier><identifier>DOI: 10.1111/cpr.13648</identifier><identifier>PMID: 38987866</identifier><language>eng</language><publisher>England: John Wiley & Sons, Inc</publisher><subject>Animals ; Cell cycle ; Cell Differentiation ; Cell fate ; Cloning ; Cysts ; Delamination ; Depletion ; DNA methylation ; Drosophila melanogaster - metabolism ; Drosophila Proteins - genetics ; Drosophila Proteins - metabolism ; Germ Cells - cytology ; Germ Cells - metabolism ; Homeostasis ; Insects ; Janus Kinases - metabolism ; Male ; Microenvironments ; Original ; Physiology ; Signal Transduction ; Snail protein ; STAT Transcription Factors - metabolism ; Stem Cell Niche - physiology ; Stem cells ; Stem Cells - cytology ; Stem Cells - metabolism ; Suppressor of Cytokine Signaling Proteins ; Testes ; Testis - cytology ; Testis - metabolism ; Transcription factors ; Transcription Factors - genetics ; Transcription Factors - metabolism</subject><ispartof>Cell proliferation, 2024-10, Vol.57 (10), p.e13648-n/a</ispartof><rights>2024 The Authors. published by Beijing Institute for Stem Cell and Regenerative Medicine and John Wiley & Sons Ltd.</rights><rights>2024 The Authors. Cell Proliferation published by Beijing Institute for Stem Cell and Regenerative Medicine and John Wiley & Sons Ltd.</rights><rights>2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the "License"). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3348-6083b15387a882926c773ea413ee4b15db500909300baada74810ad6003d6c53</cites><orcidid>0000-0002-7660-8579</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11471429/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11471429/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,861,882,1412,11543,27905,27906,45555,45556,46033,46457,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38987866$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kong, Ruiyan</creatorcontrib><creatorcontrib>Zhao, Hang</creatorcontrib><creatorcontrib>Li, Juan</creatorcontrib><creatorcontrib>Ma, Yankun</creatorcontrib><creatorcontrib>Li, Ningfang</creatorcontrib><creatorcontrib>Shi, Lin</creatorcontrib><creatorcontrib>Li, Zhouhua</creatorcontrib><title>A regulatory loop of JAK/STAT signalling and its downstream targets represses cell fate conversion and maintains male germline stem cell niche homeostasis</title><title>Cell proliferation</title><addtitle>Cell Prolif</addtitle><description>A specialised microenvironment, termed niche, provides extrinsic signals for the maintenance of residential stem cells. However, how residential stem cells maintain niche homeostasis and whether stromal niche cells could convert their fate into stem cells to replenish lost stem cells upon systemic stem cell loss remain largely unknown. Here, through systemic identification of JAK/STAT downstream targets in adult Drosophila testis, we show that Escargot (Esg), a member of the Snail family of transcriptional factors, is a putative JAK/STAT downstream target. esg is intrinsically required in cyst stem cells (CySCs) but not in germline stem cells (GSCs). esg depletion in CySCs results in CySC loss due to differentiation and non‐cell autonomous GSC loss. Interestingly, hub cells are gradually lost by delaminating from the hub and converting into CySCs in esg‐defective testes. Mechanistically, esg directly represses the expression of socs36E, the well‐known downstream target and negative regulator of JAK/STAT signalling. Finally, further depletion of socs36E completely rescues the defects observed in esg‐defective testes. Collectively, JAK/STAT target Esg suppresses SOCS36E to maintain CySC fate and repress niche cell conversion. Thus, our work uncovers a regulatory loop between JAK/STAT signalling and its downstream targets in controlling testicular niche homeostasis under physiological conditions.
Esg suppresses the expression of SOCS36E, the downstream target and negative regulator of JAK/STAT signalling. Loss of esg leads to systemic CySC loss. Once the hub senses the systemic loss of CySCs, some hub cells are delaminated from the hub and converted into functional CySCs to replace the lost CySCs.</description><subject>Animals</subject><subject>Cell cycle</subject><subject>Cell Differentiation</subject><subject>Cell fate</subject><subject>Cloning</subject><subject>Cysts</subject><subject>Delamination</subject><subject>Depletion</subject><subject>DNA methylation</subject><subject>Drosophila melanogaster - metabolism</subject><subject>Drosophila Proteins - genetics</subject><subject>Drosophila Proteins - metabolism</subject><subject>Germ Cells - cytology</subject><subject>Germ Cells - metabolism</subject><subject>Homeostasis</subject><subject>Insects</subject><subject>Janus Kinases - metabolism</subject><subject>Male</subject><subject>Microenvironments</subject><subject>Original</subject><subject>Physiology</subject><subject>Signal Transduction</subject><subject>Snail protein</subject><subject>STAT Transcription Factors - metabolism</subject><subject>Stem Cell Niche - physiology</subject><subject>Stem cells</subject><subject>Stem Cells - cytology</subject><subject>Stem Cells - metabolism</subject><subject>Suppressor of Cytokine Signaling Proteins</subject><subject>Testes</subject><subject>Testis - cytology</subject><subject>Testis - metabolism</subject><subject>Transcription factors</subject><subject>Transcription Factors - genetics</subject><subject>Transcription Factors - metabolism</subject><issn>0960-7722</issn><issn>1365-2184</issn><issn>1365-2184</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kc-KFDEQxoMo7rh68AUk4EUPvZN0Mkn6JMPg_wVF5x4y3TU9WdJJm6R3mVfxac1sr4sKBooKVb_6qORD6DklF7ScZTvGC8oEVw_QouRVVVPFH6IFaQSppKzrM_QkpStCKKNSPEZnTDVKKiEW6OcaR-gnZ3KIR-xCGHHY40_rz8vv2_UWJ9t745z1PTa-wzYn3IUbn3IEM-BsYg-lFGGMkBIk3IJzeG8y4Db4a4jJBn87ORjrc4lUbg5wD3EoqoBThmGe8rY9AD6EAULKJtn0FD3aG5fg2V0-R9t3b7ebD9Xll_cfN-vLqmWMq0oQxXZ0xZQ0StVNLVopGRhOGQAvjW63IqQhDSNkZ0xnJFeUmE4QwjrRrtg5ejPLjtNugK4Fn6Nxeox2MPGog7H67463B92Ha00pl5TXTVF4dacQw48JUtaDTac3GQ9hSpoRqSQVDT-hL_9Br8IUyxcXilJBeF2LE_V6ptoYUoqwv9-GEn1yXBfH9a3jhX3x5_r35G-LC7CcgRvr4Ph_Jb35-m2W_AXrCrex</recordid><startdate>202410</startdate><enddate>202410</enddate><creator>Kong, Ruiyan</creator><creator>Zhao, Hang</creator><creator>Li, Juan</creator><creator>Ma, Yankun</creator><creator>Li, Ningfang</creator><creator>Shi, Lin</creator><creator>Li, Zhouhua</creator><general>John Wiley & Sons, Inc</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M7P</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-7660-8579</orcidid></search><sort><creationdate>202410</creationdate><title>A regulatory loop of JAK/STAT signalling and its downstream targets represses cell fate conversion and maintains male germline stem cell niche homeostasis</title><author>Kong, Ruiyan ; Zhao, Hang ; Li, Juan ; Ma, Yankun ; Li, Ningfang ; Shi, Lin ; Li, Zhouhua</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3348-6083b15387a882926c773ea413ee4b15db500909300baada74810ad6003d6c53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Animals</topic><topic>Cell cycle</topic><topic>Cell Differentiation</topic><topic>Cell fate</topic><topic>Cloning</topic><topic>Cysts</topic><topic>Delamination</topic><topic>Depletion</topic><topic>DNA methylation</topic><topic>Drosophila melanogaster - metabolism</topic><topic>Drosophila Proteins - genetics</topic><topic>Drosophila Proteins - metabolism</topic><topic>Germ Cells - cytology</topic><topic>Germ Cells - metabolism</topic><topic>Homeostasis</topic><topic>Insects</topic><topic>Janus Kinases - metabolism</topic><topic>Male</topic><topic>Microenvironments</topic><topic>Original</topic><topic>Physiology</topic><topic>Signal Transduction</topic><topic>Snail protein</topic><topic>STAT Transcription Factors - metabolism</topic><topic>Stem Cell Niche - physiology</topic><topic>Stem cells</topic><topic>Stem Cells - cytology</topic><topic>Stem Cells - metabolism</topic><topic>Suppressor of Cytokine Signaling Proteins</topic><topic>Testes</topic><topic>Testis - cytology</topic><topic>Testis - metabolism</topic><topic>Transcription factors</topic><topic>Transcription Factors - genetics</topic><topic>Transcription Factors - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kong, Ruiyan</creatorcontrib><creatorcontrib>Zhao, Hang</creatorcontrib><creatorcontrib>Li, Juan</creatorcontrib><creatorcontrib>Ma, Yankun</creatorcontrib><creatorcontrib>Li, Ningfang</creatorcontrib><creatorcontrib>Shi, Lin</creatorcontrib><creatorcontrib>Li, Zhouhua</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Wiley Free Content</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cell proliferation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kong, Ruiyan</au><au>Zhao, Hang</au><au>Li, Juan</au><au>Ma, Yankun</au><au>Li, Ningfang</au><au>Shi, Lin</au><au>Li, Zhouhua</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A regulatory loop of JAK/STAT signalling and its downstream targets represses cell fate conversion and maintains male germline stem cell niche homeostasis</atitle><jtitle>Cell proliferation</jtitle><addtitle>Cell Prolif</addtitle><date>2024-10</date><risdate>2024</risdate><volume>57</volume><issue>10</issue><spage>e13648</spage><epage>n/a</epage><pages>e13648-n/a</pages><issn>0960-7722</issn><issn>1365-2184</issn><eissn>1365-2184</eissn><abstract>A specialised microenvironment, termed niche, provides extrinsic signals for the maintenance of residential stem cells. However, how residential stem cells maintain niche homeostasis and whether stromal niche cells could convert their fate into stem cells to replenish lost stem cells upon systemic stem cell loss remain largely unknown. Here, through systemic identification of JAK/STAT downstream targets in adult Drosophila testis, we show that Escargot (Esg), a member of the Snail family of transcriptional factors, is a putative JAK/STAT downstream target. esg is intrinsically required in cyst stem cells (CySCs) but not in germline stem cells (GSCs). esg depletion in CySCs results in CySC loss due to differentiation and non‐cell autonomous GSC loss. Interestingly, hub cells are gradually lost by delaminating from the hub and converting into CySCs in esg‐defective testes. Mechanistically, esg directly represses the expression of socs36E, the well‐known downstream target and negative regulator of JAK/STAT signalling. Finally, further depletion of socs36E completely rescues the defects observed in esg‐defective testes. Collectively, JAK/STAT target Esg suppresses SOCS36E to maintain CySC fate and repress niche cell conversion. Thus, our work uncovers a regulatory loop between JAK/STAT signalling and its downstream targets in controlling testicular niche homeostasis under physiological conditions.
Esg suppresses the expression of SOCS36E, the downstream target and negative regulator of JAK/STAT signalling. Loss of esg leads to systemic CySC loss. Once the hub senses the systemic loss of CySCs, some hub cells are delaminated from the hub and converted into functional CySCs to replace the lost CySCs.</abstract><cop>England</cop><pub>John Wiley & Sons, Inc</pub><pmid>38987866</pmid><doi>10.1111/cpr.13648</doi><tpages>16</tpages><orcidid>https://orcid.org/0000-0002-7660-8579</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Cell cycle Cell Differentiation Cell fate Cloning Cysts Delamination Depletion DNA methylation Drosophila melanogaster - metabolism Drosophila Proteins - genetics Drosophila Proteins - metabolism Germ Cells - cytology Germ Cells - metabolism Homeostasis Insects Janus Kinases - metabolism Male Microenvironments Original Physiology Signal Transduction Snail protein STAT Transcription Factors - metabolism Stem Cell Niche - physiology Stem cells Stem Cells - cytology Stem Cells - metabolism Suppressor of Cytokine Signaling Proteins Testes Testis - cytology Testis - metabolism Transcription factors Transcription Factors - genetics Transcription Factors - metabolism |
| title | A regulatory loop of JAK/STAT signalling and its downstream targets represses cell fate conversion and maintains male germline stem cell niche homeostasis |
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