Distinct Effects of Heparin and Interleukin‐4 Functionalization on Macrophage Polarization and In Situ Arterial Tissue Regeneration Using Resorbable Supramolecular Vascular Grafts in Rats

Two of the greatest challenges for successful application of small‐diameter in situ tissue‐engineered vascular grafts are 1) preventing thrombus formation and 2) harnessing the inflammatory response to the graft to guide functional tissue regeneration. This study evaluates the in vivo performance of...

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Veröffentlicht in:	Advanced healthcare materials 2021-11, Vol.10 (21), p.e2101103-n/a
Hauptverfasser:	Bonito, Valentina, Koch, Suzanne E., Krebber, Merle M., Carvajal‐Berrio, Daniel A., Marzi, Julia, Duijvelshoff, Renee, Lurier, Emily B., Buscone, Serena, Dekker, Sylvia, Jong, Simone M. J., Mes, Tristan, Vaessen, Koen R. D., Brauchle, Eva M., Bosman, Anton W., Schenke‐Layland, Katja, Verhaar, Marianne C., Dankers, Patricia Y. W., Smits, Anthal I. P. M., Bouten, Carlijn V. C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticoagulants Aorta biodegradable polymers Blood Vessel Prosthesis cardiovascular Chemical fingerprinting Cytokines Elastomers Grafting Heparin Hyperplasia immunomodulatory biomaterials in situ tissue engineering In vivo methods and tests Inflammation Inflammatory response Interleukin 4 Macrophages Polarization Raman microspectroscopy Rats Regeneration supramolecular chemistry Thrombosis Tissue Engineering Tissue Scaffolds tissue‐engineered vascular graft (TEVG)
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