Changes in fluconazole pharmacokinetics can impact on antifungal effectiveness in critically ill burn patients: a Pharmacokinetic-Pharmacodynamic (PK/PD) approach

•Fluconazole pharmacokinetics is significantly altered in critically ill burn patients.•Half-life and total body clearance were correlated to volume of distribution decrease.•High-dose fluconazole may be necessary to guarantee coverage against Candida glabrata. The Fluconazole pharmacokinetic-pharma...

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Veröffentlicht in:	Clinics (São Paulo, Brazil) Brazil), 2024, Vol.79, p.100491, Article 100491
Hauptverfasser:	Matsuno, Victor Kaneko, Campos, Edvaldo Vieira de, Silva Junior, Elson Mendes da, Silva Junior, João Manoel da, Gomez, David de Souza, Santos, Silvia Regina Cavani Jorge
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antifungal Agents - administration & dosage Antifungal Agents - pharmacokinetics Antifungal Agents - therapeutic use Area Under Curve Burn Burns - drug therapy Candida - drug effects Candidiasis Candidiasis - drug therapy Critical care Critical Illness Dose-Response Relationship, Drug Female Fluconazole Fluconazole - administration & dosage Fluconazole - pharmacokinetics Fluconazole - pharmacology Fluconazole - therapeutic use Humans Infusions, Intravenous Male MEDICINE, GENERAL & INTERNAL Microbial Sensitivity Tests Middle Aged Original Pharmacokinetics Reference Values Time Factors Treatment Outcome Young Adult
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