Metabolic landscape of the healthy pancreas and pancreatic tumor microenvironment

Pancreatic cancer, one of the deadliest human malignancies, is characterized by a fibro-inflammatory tumor microenvironment and wide array of metabolic alterations. To comprehensively map metabolism in a cell type-specific manner, we harnessed a unique single-cell RNA-sequencing dataset of normal hu...

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Veröffentlicht in:	JCI insight 2024-08, Vol.9 (18)
Hauptverfasser:	Bonilla, Monica E, Radyk, Megan D, Perricone, Matthew D, Elhossiny, Ahmed M, Harold, Alexis C, Medina-Cabrera, Paola I, Kadiyala, Padma, Shi, Jiaqi, Frankel, Timothy L, Carpenter, Eileen S, Green, Michael D, Mitrea, Cristina, Lyssiotis, Costas A, Pasca di Magliano, Marina
Format:	Artikel
Sprache:	eng
Schlagworte:	Cholesterol - metabolism Humans Lipid Metabolism Mitochondria - metabolism Oxidative Phosphorylation Pancreas - metabolism Pancreas - pathology Pancreatic Neoplasms - genetics Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Single-Cell Analysis Tumor Microenvironment Tumor-Associated Macrophages - immunology Tumor-Associated Macrophages - metabolism
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