High-Grade Hepatic Spindle Cell Carcinoma as a Cause of Diffuse Right Hepatic Lobe Hypermetabolism Identified With 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (18F-FDG PET/CT) Imaging
We present a rare case of high-grade spindle cell liver carcinoma investigated using F-fluorodeoxyglucose positron emission tomography/computed tomography ( F-FDG PET/CT) in a 70-year-old man with worsened clinical symptoms for more than three months. These include hiccups, belching, loss of appetit...
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| Veröffentlicht in: | Curēus (Palo Alto, CA) CA), 2024-09, Vol.16 (9), p.e68793 |
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| creator | Al-Adhami, Dhuha Al-Shatti, Marwa Alrabi, Kamal Haidar, Mohammad Al-Ibraheem, Akram |
| description | We present a rare case of high-grade spindle cell liver carcinoma investigated using
F-fluorodeoxyglucose positron emission tomography/computed tomography (
F-FDG PET/CT) in a 70-year-old man with worsened clinical symptoms for more than three months. These include hiccups, belching, loss of appetite, and significant weight loss of 30 kg over the last three months.
F-FDG PET/CT was employed as part of the initial diagnostic assessment, revealing intense diffuse right hepatic lobe hypermetabolism. Fused PET/CT images revealed a locally confined right hepatic lobe tumor exhibiting heterogeneous metabolic activity with predominant hypermetabolism surrounding two internally contained hypometabolic islands. These findings suggested an aggressive and unusual neoplastic pattern. Ultrasound-guided biopsy confirmed high-grade spindle cell sarcoma of the liver. Unfortunately, the patient passed away shortly thereafter, precluding therapeutic decisions. |
| doi_str_mv | 10.7759/cureus.68793 |
| format | Article |
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F-fluorodeoxyglucose positron emission tomography/computed tomography (
F-FDG PET/CT) in a 70-year-old man with worsened clinical symptoms for more than three months. These include hiccups, belching, loss of appetite, and significant weight loss of 30 kg over the last three months.
F-FDG PET/CT was employed as part of the initial diagnostic assessment, revealing intense diffuse right hepatic lobe hypermetabolism. Fused PET/CT images revealed a locally confined right hepatic lobe tumor exhibiting heterogeneous metabolic activity with predominant hypermetabolism surrounding two internally contained hypometabolic islands. These findings suggested an aggressive and unusual neoplastic pattern. Ultrasound-guided biopsy confirmed high-grade spindle cell sarcoma of the liver. Unfortunately, the patient passed away shortly thereafter, precluding therapeutic decisions.</description><identifier>ISSN: 2168-8184</identifier><identifier>EISSN: 2168-8184</identifier><identifier>DOI: 10.7759/cureus.68793</identifier><identifier>PMID: 39371758</identifier><language>eng</language><publisher>United States: Cureus Inc</publisher><subject>Anemia ; Antigens ; Biopsy ; Bone marrow ; Hemoglobin ; Liver cancer ; Metastasis ; Nuclear Medicine ; Oncology ; Pathology ; Phosphatase ; Sarcoma ; Tomography ; Tumors</subject><ispartof>Curēus (Palo Alto, CA), 2024-09, Vol.16 (9), p.e68793</ispartof><rights>Copyright © 2024, Al-Adhami et al.</rights><rights>Copyright © 2024, Al-Adhami et al. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright © 2024, Al-Adhami et al. 2024 Al-Adhami et al.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c300t-9e397f67cfd6b7d0644b770bb4d6c7cb944e43c457e55deca4348414e446d79e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11456283/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11456283/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39371758$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Al-Adhami, Dhuha</creatorcontrib><creatorcontrib>Al-Shatti, Marwa</creatorcontrib><creatorcontrib>Alrabi, Kamal</creatorcontrib><creatorcontrib>Haidar, Mohammad</creatorcontrib><creatorcontrib>Al-Ibraheem, Akram</creatorcontrib><title>High-Grade Hepatic Spindle Cell Carcinoma as a Cause of Diffuse Right Hepatic Lobe Hypermetabolism Identified With 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (18F-FDG PET/CT) Imaging</title><title>Curēus (Palo Alto, CA)</title><addtitle>Cureus</addtitle><description>We present a rare case of high-grade spindle cell liver carcinoma investigated using
F-fluorodeoxyglucose positron emission tomography/computed tomography (
F-FDG PET/CT) in a 70-year-old man with worsened clinical symptoms for more than three months. These include hiccups, belching, loss of appetite, and significant weight loss of 30 kg over the last three months.
F-FDG PET/CT was employed as part of the initial diagnostic assessment, revealing intense diffuse right hepatic lobe hypermetabolism. Fused PET/CT images revealed a locally confined right hepatic lobe tumor exhibiting heterogeneous metabolic activity with predominant hypermetabolism surrounding two internally contained hypometabolic islands. These findings suggested an aggressive and unusual neoplastic pattern. Ultrasound-guided biopsy confirmed high-grade spindle cell sarcoma of the liver. Unfortunately, the patient passed away shortly thereafter, precluding therapeutic decisions.</description><subject>Anemia</subject><subject>Antigens</subject><subject>Biopsy</subject><subject>Bone marrow</subject><subject>Hemoglobin</subject><subject>Liver cancer</subject><subject>Metastasis</subject><subject>Nuclear Medicine</subject><subject>Oncology</subject><subject>Pathology</subject><subject>Phosphatase</subject><subject>Sarcoma</subject><subject>Tomography</subject><subject>Tumors</subject><issn>2168-8184</issn><issn>2168-8184</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNpdks1u1DAUhSMEolXpjjWyxKZIpGPHTuysEErnTxqJCgaxtBzbybhK4mDHiHnOvlA9nTIUVr6-PvfTPdZJkrcIXlOalzMZnA7-umC0xC-S8wwVLGWIkZfP6rPk0vs7CCGCNIMUvk7OcIkpojk7T-5Xpt2lSyeUBis9islI8G00g-o0qHTXgUo4aQbbCyA8EPEavAa2ATemaQ7l1zg_nUY3to6c_ahdrydR2874HqyVHibTGK3ADzPtAGKLdNEF66zS9ve-7YK0kXRrvZmcHcC8N96bWGxtb1snxt1-Vtl-DFMk_O2Bq0fQzRLczrezavsBrHvRmqF9k7xqROf15dN5kXxfzLfVKt18Wa6rz5tUYgintNS4pE1BZaOKmipYEFJTCuuaqEJSWZeEaIIlyanOc6WlIJgwgmKTFIrG6Yvk05E7hrrXSkaXTnR8dKYXbs-tMPzfl8HseGt_cYRIXmQMR8LVE8HZn0H7iUfrMn67GLQNnmOEMCUM5wfp-_-kdza4IfqLqixjeYFKGlUfjyrprPdON6dtEOSHxPBjYvhjYqL83XMHJ_GffOAHAuG_-w</recordid><startdate>20240906</startdate><enddate>20240906</enddate><creator>Al-Adhami, Dhuha</creator><creator>Al-Shatti, Marwa</creator><creator>Alrabi, Kamal</creator><creator>Haidar, Mohammad</creator><creator>Al-Ibraheem, Akram</creator><general>Cureus Inc</general><general>Cureus</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20240906</creationdate><title>High-Grade Hepatic Spindle Cell Carcinoma as a Cause of Diffuse Right Hepatic Lobe Hypermetabolism Identified With 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (18F-FDG PET/CT) Imaging</title><author>Al-Adhami, Dhuha ; 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F-fluorodeoxyglucose positron emission tomography/computed tomography (
F-FDG PET/CT) in a 70-year-old man with worsened clinical symptoms for more than three months. These include hiccups, belching, loss of appetite, and significant weight loss of 30 kg over the last three months.
F-FDG PET/CT was employed as part of the initial diagnostic assessment, revealing intense diffuse right hepatic lobe hypermetabolism. Fused PET/CT images revealed a locally confined right hepatic lobe tumor exhibiting heterogeneous metabolic activity with predominant hypermetabolism surrounding two internally contained hypometabolic islands. These findings suggested an aggressive and unusual neoplastic pattern. Ultrasound-guided biopsy confirmed high-grade spindle cell sarcoma of the liver. Unfortunately, the patient passed away shortly thereafter, precluding therapeutic decisions.</abstract><cop>United States</cop><pub>Cureus Inc</pub><pmid>39371758</pmid><doi>10.7759/cureus.68793</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| source | PubMed Central; PubMed Central Open Access |
| subjects | Anemia Antigens Biopsy Bone marrow Hemoglobin Liver cancer Metastasis Nuclear Medicine Oncology Pathology Phosphatase Sarcoma Tomography Tumors |
| title | High-Grade Hepatic Spindle Cell Carcinoma as a Cause of Diffuse Right Hepatic Lobe Hypermetabolism Identified With 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (18F-FDG PET/CT) Imaging |
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