$Exercise training decreases the load and changes the content of circulating SDS-resistant protein aggregates in patients with heart failure with reduced ejection fraction$

Exercise training decreases the load and changes the content of circulating SDS-resistant protein aggregates in patients with heart failure with reduced ejection fraction

Background Heart failure (HF) often disrupts the protein quality control (PQC) system leading to protein aggregate accumulation. Evidence from tissue biopsies showed that exercise restores PQC system in HF; however, little is known about its effects on plasma proteostasis. Aim To determine the effec...

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Veröffentlicht in:	Molecular and cellular biochemistry 2024-10, Vol.479 (10), p.2711-2722
Hauptverfasser:	Gouveia, Marisol, Schmidt, Cristine, Basilio, Priscilla Gois, Aveiro, Susana S., Domingues, Pedro, Xia, Ke, Colón, Wilfredo, Vitorino, Rui, Ferreira, Rita, Santos, Mário, Vieira, Sandra I., Ribeiro, Fernando
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aggregates Bioaccumulation Biochemistry Biomedical and Life Sciences Biopsy Brain natriuretic peptide C-reactive protein C-Reactive Protein - metabolism Cancer Research Cardiology Cardiorespiratory fitness Circulation Composition effects Congestive heart failure Ejection fraction Exercise Exercise - physiology Exercise Therapy - methods Female Fitness Fitness training programs Haptoglobin Heart failure Heart Failure - blood Heart Failure - physiopathology Heart Failure - therapy Humans Life Sciences Male Mass spectrometry Mass spectroscopy Medical Biochemistry Middle Aged Natriuretic Peptide, Brain - blood Peptide Fragments - blood Physical fitness Physical training Plasma Plasma levels Protein Aggregates Protein composition Proteins Quality control Quality of Life Stroke Volume
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