Influence of tumour grade on disease survival in male breast cancer patients: a systematic review
Purpose Histological grading of tumours is a well-established biomarker used to guide treatment in female breast cancer. However, its significance in male breast cancer remains unclear. This systematic review investigates the prognostic significance of tumour grade in relation to breast cancer-speci...
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| Veröffentlicht in: | Breast cancer research and treatment 2024-11, Vol.208 (1), p.1-8 |
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| creator | Kinsey-Trotman, Stephen Nguyen, Alain Edwards, Suzanne Swalling, Adam Dasari, Pallave Walsh, David Ingman, Wendy V. |
| description | Purpose
Histological grading of tumours is a well-established biomarker used to guide treatment in female breast cancer. However, its significance in male breast cancer remains unclear. This systematic review investigates the prognostic significance of tumour grade in relation to breast cancer-specific survival (BCSS) in male breast cancer patients undergoing surgery.
Methods
MEDLINE, PUBMED Central and EMBASE databases were searched to identify randomised trials and observational studies related to male breast neoplasms, tumour grading, recurrence, and survival.
Results
A total of fifteen observational type studies were included in the review. A significant association between tumour grade and BCSS was reported in a majority of studies. This association was most evident with regard to high-grade (grade III) compared to low grade (grade I) tumours, with a significant relationship in 4 out of 4 studies. For intermediate-grade II tumours an association was demonstrated in a minority of studies.
Conclusions
This study confirms an association between high-grade male breast cancers and poorer disease-specific survival, however, the significance of intermediate-grade tumours remains unclear. Further research is required to investigate the biology of male breast cancer in relation to histological grade and optimally define intermediate-grade disease. |
| doi_str_mv | 10.1007/s10549-024-07446-z |
| format | Article |
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Histological grading of tumours is a well-established biomarker used to guide treatment in female breast cancer. However, its significance in male breast cancer remains unclear. This systematic review investigates the prognostic significance of tumour grade in relation to breast cancer-specific survival (BCSS) in male breast cancer patients undergoing surgery.
Methods
MEDLINE, PUBMED Central and EMBASE databases were searched to identify randomised trials and observational studies related to male breast neoplasms, tumour grading, recurrence, and survival.
Results
A total of fifteen observational type studies were included in the review. A significant association between tumour grade and BCSS was reported in a majority of studies. This association was most evident with regard to high-grade (grade III) compared to low grade (grade I) tumours, with a significant relationship in 4 out of 4 studies. For intermediate-grade II tumours an association was demonstrated in a minority of studies.
Conclusions
This study confirms an association between high-grade male breast cancers and poorer disease-specific survival, however, the significance of intermediate-grade tumours remains unclear. Further research is required to investigate the biology of male breast cancer in relation to histological grade and optimally define intermediate-grade disease.</description><identifier>ISSN: 0167-6806</identifier><identifier>ISSN: 1573-7217</identifier><identifier>EISSN: 1573-7217</identifier><identifier>DOI: 10.1007/s10549-024-07446-z</identifier><identifier>PMID: 39095633</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Breast cancer ; Breast Neoplasms, Male - mortality ; Breast Neoplasms, Male - pathology ; Clinical trials ; Humans ; Male ; Medicine ; Medicine & Public Health ; Mens health ; Neoplasm Grading ; Neoplasm Recurrence, Local - pathology ; Oncology ; Patients ; Prognosis ; Review ; Survival ; Systematic review ; Tumors</subject><ispartof>Breast cancer research and treatment, 2024-11, Vol.208 (1), p.1-8</ispartof><rights>The Author(s) 2024</rights><rights>2024. The Author(s).</rights><rights>The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s) 2024 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c356t-361ab8b0ac0aa57340638668467c879c7c4cad0e1bf9597d662f6798deec53d63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10549-024-07446-z$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10549-024-07446-z$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39095633$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kinsey-Trotman, Stephen</creatorcontrib><creatorcontrib>Nguyen, Alain</creatorcontrib><creatorcontrib>Edwards, Suzanne</creatorcontrib><creatorcontrib>Swalling, Adam</creatorcontrib><creatorcontrib>Dasari, Pallave</creatorcontrib><creatorcontrib>Walsh, David</creatorcontrib><creatorcontrib>Ingman, Wendy V.</creatorcontrib><title>Influence of tumour grade on disease survival in male breast cancer patients: a systematic review</title><title>Breast cancer research and treatment</title><addtitle>Breast Cancer Res Treat</addtitle><addtitle>Breast Cancer Res Treat</addtitle><description>Purpose
Histological grading of tumours is a well-established biomarker used to guide treatment in female breast cancer. However, its significance in male breast cancer remains unclear. This systematic review investigates the prognostic significance of tumour grade in relation to breast cancer-specific survival (BCSS) in male breast cancer patients undergoing surgery.
Methods
MEDLINE, PUBMED Central and EMBASE databases were searched to identify randomised trials and observational studies related to male breast neoplasms, tumour grading, recurrence, and survival.
Results
A total of fifteen observational type studies were included in the review. A significant association between tumour grade and BCSS was reported in a majority of studies. This association was most evident with regard to high-grade (grade III) compared to low grade (grade I) tumours, with a significant relationship in 4 out of 4 studies. For intermediate-grade II tumours an association was demonstrated in a minority of studies.
Conclusions
This study confirms an association between high-grade male breast cancers and poorer disease-specific survival, however, the significance of intermediate-grade tumours remains unclear. Further research is required to investigate the biology of male breast cancer in relation to histological grade and optimally define intermediate-grade disease.</description><subject>Breast cancer</subject><subject>Breast Neoplasms, Male - mortality</subject><subject>Breast Neoplasms, Male - pathology</subject><subject>Clinical trials</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mens health</subject><subject>Neoplasm Grading</subject><subject>Neoplasm Recurrence, Local - pathology</subject><subject>Oncology</subject><subject>Patients</subject><subject>Prognosis</subject><subject>Review</subject><subject>Survival</subject><subject>Systematic review</subject><subject>Tumors</subject><issn>0167-6806</issn><issn>1573-7217</issn><issn>1573-7217</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><recordid>eNp9kUtv1TAQhS1ERS-FP8ACWWLDJnQcv2I2CFU8KlViA2tr4kwurvK42Mmt2l-Pyy0FumBleeab4zk-jL0Q8EYA2NMsQCtXQa0qsEqZ6uYR2whtZWVrYR-zDQhjK9OAOWZPc74EAGfBPWHH0oHTRsoNw_OpH1aaAvG558s6zmvi24RduU-8i5kwE89r2sc9DjxOfMSBeJtKfeEBy2DiO1wiTUt-y5Hn67zQWAqBJ9pHunrGjnocMj2_O0_Yt48fvp59ri6-fDo_e39RBanNUkkjsG1awACIxYMCIxtjGmVsaKwLNqiAHZBoe6ed7Yype2Nd0xEFLTsjT9i7g-5ubUfqQlko4eB3KY6Yrv2M0f_bmeJ3v533Xgila2VFUXh9p5DmHyvlxY8xBxoGnGhes5fQWG1qJ2VBXz1AL8vHTcWfl0LUzmoldKHqAxXSnHOi_n4bAf42Qn-I0JcI_a8I_U0Zevm3j_uR35kVQB6AXFrTltKft_8j-xNt56js</recordid><startdate>20241101</startdate><enddate>20241101</enddate><creator>Kinsey-Trotman, Stephen</creator><creator>Nguyen, Alain</creator><creator>Edwards, Suzanne</creator><creator>Swalling, Adam</creator><creator>Dasari, Pallave</creator><creator>Walsh, David</creator><creator>Ingman, Wendy V.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20241101</creationdate><title>Influence of tumour grade on disease survival in male breast cancer patients: a systematic review</title><author>Kinsey-Trotman, Stephen ; Nguyen, Alain ; Edwards, Suzanne ; Swalling, Adam ; Dasari, Pallave ; Walsh, David ; Ingman, Wendy V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-361ab8b0ac0aa57340638668467c879c7c4cad0e1bf9597d662f6798deec53d63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Breast cancer</topic><topic>Breast Neoplasms, Male - mortality</topic><topic>Breast Neoplasms, Male - pathology</topic><topic>Clinical trials</topic><topic>Humans</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mens health</topic><topic>Neoplasm Grading</topic><topic>Neoplasm Recurrence, Local - pathology</topic><topic>Oncology</topic><topic>Patients</topic><topic>Prognosis</topic><topic>Review</topic><topic>Survival</topic><topic>Systematic review</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kinsey-Trotman, Stephen</creatorcontrib><creatorcontrib>Nguyen, Alain</creatorcontrib><creatorcontrib>Edwards, Suzanne</creatorcontrib><creatorcontrib>Swalling, Adam</creatorcontrib><creatorcontrib>Dasari, Pallave</creatorcontrib><creatorcontrib>Walsh, David</creatorcontrib><creatorcontrib>Ingman, Wendy V.</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Breast cancer research and treatment</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kinsey-Trotman, Stephen</au><au>Nguyen, Alain</au><au>Edwards, Suzanne</au><au>Swalling, Adam</au><au>Dasari, Pallave</au><au>Walsh, David</au><au>Ingman, Wendy V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of tumour grade on disease survival in male breast cancer patients: a systematic review</atitle><jtitle>Breast cancer research and treatment</jtitle><stitle>Breast Cancer Res Treat</stitle><addtitle>Breast Cancer Res Treat</addtitle><date>2024-11-01</date><risdate>2024</risdate><volume>208</volume><issue>1</issue><spage>1</spage><epage>8</epage><pages>1-8</pages><issn>0167-6806</issn><issn>1573-7217</issn><eissn>1573-7217</eissn><abstract>Purpose
Histological grading of tumours is a well-established biomarker used to guide treatment in female breast cancer. However, its significance in male breast cancer remains unclear. This systematic review investigates the prognostic significance of tumour grade in relation to breast cancer-specific survival (BCSS) in male breast cancer patients undergoing surgery.
Methods
MEDLINE, PUBMED Central and EMBASE databases were searched to identify randomised trials and observational studies related to male breast neoplasms, tumour grading, recurrence, and survival.
Results
A total of fifteen observational type studies were included in the review. A significant association between tumour grade and BCSS was reported in a majority of studies. This association was most evident with regard to high-grade (grade III) compared to low grade (grade I) tumours, with a significant relationship in 4 out of 4 studies. For intermediate-grade II tumours an association was demonstrated in a minority of studies.
Conclusions
This study confirms an association between high-grade male breast cancers and poorer disease-specific survival, however, the significance of intermediate-grade tumours remains unclear. Further research is required to investigate the biology of male breast cancer in relation to histological grade and optimally define intermediate-grade disease.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>39095633</pmid><doi>10.1007/s10549-024-07446-z</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Breast cancer Breast Neoplasms, Male - mortality Breast Neoplasms, Male - pathology Clinical trials Humans Male Medicine Medicine & Public Health Mens health Neoplasm Grading Neoplasm Recurrence, Local - pathology Oncology Patients Prognosis Review Survival Systematic review Tumors |
| title | Influence of tumour grade on disease survival in male breast cancer patients: a systematic review |
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