Ultrastructure of Ebola virus particles in human liver
Electron microscopy of tissues from two necropsies carried out in the Sudan on patients with Ebola virus infection identified virus particles in lung and spleen, but the main concentrations of Ebola particles were seen in liver sections. Viral precursor proteins and cores were found in functional li...
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| Veröffentlicht in: | Journal of clinical pathology 1978-03, Vol.31 (3), p.201-208 |
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| container_title | Journal of clinical pathology |
| container_volume | 31 |
| creator | Ellis, D S Simpson, I H Francis, D P Knobloch, J Bowen, E T Lolik, P Deng, I M |
| description | Electron microscopy of tissues from two necropsies carried out in the Sudan on patients with Ebola virus infection identified virus particles in lung and spleen, but the main concentrations of Ebola particles were seen in liver sections. Viral precursor proteins and cores were found in functional liver cells, often aligned in membrane-bound aggregations. Complete virions, usually found only extracellularly, were mainly seen as long tubular forms, some without cores. Many tubular forms had 'enlarged heads' or 'spores' and some branched and torus forms were identified. The size and structure of the Ebola virus forms appear to be virtually indistinguishable from those of Marburg virus. |
| doi_str_mv | 10.1136/jcp.31.3.201 |
| format | Article |
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Viral precursor proteins and cores were found in functional liver cells, often aligned in membrane-bound aggregations. Complete virions, usually found only extracellularly, were mainly seen as long tubular forms, some without cores. Many tubular forms had 'enlarged heads' or 'spores' and some branched and torus forms were identified. The size and structure of the Ebola virus forms appear to be virtually indistinguishable from those of Marburg virus.</description><identifier>ISSN: 0021-9746</identifier><identifier>EISSN: 1472-4146</identifier><identifier>DOI: 10.1136/jcp.31.3.201</identifier><identifier>PMID: 641193</identifier><identifier>CODEN: JCPAAK</identifier><language>eng</language><publisher>England: BMJ Publishing Group Ltd and Association of Clinical Pathologists</publisher><subject>Female ; Humans ; Liver - microbiology ; Liver - ultrastructure ; Male ; Marburgvirus - ultrastructure ; Microscopy, Electron ; Rhabdoviridae - ultrastructure</subject><ispartof>Journal of clinical pathology, 1978-03, Vol.31 (3), p.201-208</ispartof><rights>Copyright BMJ Publishing Group LTD Mar 1978</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b542t-f2fea88bd89b176e0b62b496302bfc674f313d2f0a38ce2f154e713f55e3a9af3</citedby><cites>FETCH-LOGICAL-b542t-f2fea88bd89b176e0b62b496302bfc674f313d2f0a38ce2f154e713f55e3a9af3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1145228/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1145228/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/641193$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ellis, D S</creatorcontrib><creatorcontrib>Simpson, I H</creatorcontrib><creatorcontrib>Francis, D P</creatorcontrib><creatorcontrib>Knobloch, J</creatorcontrib><creatorcontrib>Bowen, E T</creatorcontrib><creatorcontrib>Lolik, P</creatorcontrib><creatorcontrib>Deng, I M</creatorcontrib><title>Ultrastructure of Ebola virus particles in human liver</title><title>Journal of clinical pathology</title><addtitle>J Clin Pathol</addtitle><description>Electron microscopy of tissues from two necropsies carried out in the Sudan on patients with Ebola virus infection identified virus particles in lung and spleen, but the main concentrations of Ebola particles were seen in liver sections. Viral precursor proteins and cores were found in functional liver cells, often aligned in membrane-bound aggregations. Complete virions, usually found only extracellularly, were mainly seen as long tubular forms, some without cores. Many tubular forms had 'enlarged heads' or 'spores' and some branched and torus forms were identified. The size and structure of the Ebola virus forms appear to be virtually indistinguishable from those of Marburg virus.</description><subject>Female</subject><subject>Humans</subject><subject>Liver - microbiology</subject><subject>Liver - ultrastructure</subject><subject>Male</subject><subject>Marburgvirus - ultrastructure</subject><subject>Microscopy, Electron</subject><subject>Rhabdoviridae - ultrastructure</subject><issn>0021-9746</issn><issn>1472-4146</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1978</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kb1vFDEQxS3E13HQUVKsFAka9vB4vLa3QYpO-ZIiaEh0nWXv2cTHfhz27gn--xhtdAKKVFO8n968mUfIW6ArABSfds1-hbDCFaPwhCyAS1Zy4OIpWVDKoKwlFy_Jq5R2lAJKwBfkueAANS6IuGnHaNIYp2acoisGX5zZoTXFIcQpFXsTx9C0LhWhL-6mzvRFGw4uvibPvGmTe_Mwl-Tm_Ozb-rK8_npxtT69Lm3F2Vh65p1Rym5VbUEKR61gltcCKbO-EZJ7BNwyTw2qxjEPFXc5n68qh6Y2Hpfk8-y7n2znto3rc9pW72PoTPytBxP0v0of7vT34aABeMWYygbvHwzi8HNyadRdSI1rW9O7YUpaoaqVyK9YkpP_wN0wxT4fp0FKymkNnGXq40w1cUgpOn-MAlT_KUPnMjSCRp3LyPi7v-Mf4fn7WS5nOaTR_TqqJv7QQqKs9Jfbtb6tFG4uNxd6k_kPM2-73eOL7wFqgqEa</recordid><startdate>19780301</startdate><enddate>19780301</enddate><creator>Ellis, D S</creator><creator>Simpson, I H</creator><creator>Francis, D P</creator><creator>Knobloch, J</creator><creator>Bowen, E T</creator><creator>Lolik, P</creator><creator>Deng, I M</creator><general>BMJ Publishing Group Ltd and Association of Clinical Pathologists</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19780301</creationdate><title>Ultrastructure of Ebola virus particles in human liver</title><author>Ellis, D S ; 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Viral precursor proteins and cores were found in functional liver cells, often aligned in membrane-bound aggregations. Complete virions, usually found only extracellularly, were mainly seen as long tubular forms, some without cores. Many tubular forms had 'enlarged heads' or 'spores' and some branched and torus forms were identified. The size and structure of the Ebola virus forms appear to be virtually indistinguishable from those of Marburg virus.</abstract><cop>England</cop><pub>BMJ Publishing Group Ltd and Association of Clinical Pathologists</pub><pmid>641193</pmid><doi>10.1136/jcp.31.3.201</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Female Humans Liver - microbiology Liver - ultrastructure Male Marburgvirus - ultrastructure Microscopy, Electron Rhabdoviridae - ultrastructure |
| title | Ultrastructure of Ebola virus particles in human liver |
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