Normative Profile of Retinal Nerve Fiber Layer Thickness and Lamina Cribrosa-Related Parameters in a Healthy Non-Glaucoma Cynomolgus Monkey Colony
The purpose of this study was to investigate the normal range of ophthalmic parameters and the correlations between systematic and ocular parameters and retinal nerve fiber layer (RNFL) thickness among a healthy non-glaucoma cynomolgus monkey colony. All included monkeys were given detailed ophthalm...
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| creator | Wu, Jian Li, Ruyue Zhu, Sirui Chen, Kezhe Lin, Caixia Tian, Jiaxin Pan, Lijie Liu, Hongyi Jia, Xu Yu, Ziyu Li, Zhidong Zhu, Yingting Liu, Wei Yang, Chenlong Wong, Chiwai Wang, Ningli Zhuo, Yehong |
| description | The purpose of this study was to investigate the normal range of ophthalmic parameters and the correlations between systematic and ocular parameters and retinal nerve fiber layer (RNFL) thickness among a healthy non-glaucoma cynomolgus monkey colony.
All included monkeys were given detailed ophthalmic examinations, including anterior and posterior segments. Furthermore, univariate and multivariate linear regression models were conducted to estimate the relationship between systemic and ophthalmic parameters and global RNFL thickness.
A total of 349 non-glaucoma monkeys (18.69 ± 2.88 years old) were collected. The global RNFL thickness was 94.61 ± 10.13 µm, and sex-specific differences existed in all sectors. The decreasing trend of RNFL is as follows: inferotemporal, superotemporal, inferonasal, superonasal, temporal, and nasal. For lamina cribrosa (LC)-related parameters, cup depth (P < 0.01), LC thickness (P = 0.014), and Bruch's membrane opening (BMO) - minimum rim width 2 (P = 0.002) were greater in the male group. However, LC depth (P = 0.02), anterior laminar insertion depth-1 (P = 0.009), and mean anterior laminar insertion depth (P = 0.029) of female monkeys were greater than those of male monkeys. In multivariate linear regression, only older age was significantly related to reduced global RNFL thickness (P < 0.001).
Our findings suggest the differences in RNFL thickness distribution and sex between non-glaucoma cynomolgus monkeys and humans. Therefore, the impact of this difference on outcomes should be fully considered in laboratory animal studies. Our findings are also significant in terms of developing a normative optical coherence tomography (OCT) database in nonhuman primates (NHPs).
We found that the differences in RNFL thickness distribution and sex between non-glaucoma cynomolgus monkey colonies and humans should be thoroughly taken into account in laboratory animal studies. |
| doi_str_mv | 10.1167/tvst.13.10.6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11451825</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3112530844</sourcerecordid><originalsourceid>FETCH-LOGICAL-c234t-9828e890788d4d6c2a503fe233ef05db2644e9fa6445b04f3028731673485d243</originalsourceid><addsrcrecordid>eNpVkU1v3CAQhlHVqomS3HKuOPZQb_kyi09VtcqXtN1GUXJG2B5naTCkgFfy3-gvLqt8KOHAMMzDO2hehE4pWVAql9_zLuUF5YuSyw_okFEpKlY39OOb8wE6SekPKUuqWgj5GR3whkvK6fIQ_duEOJpsd4CvYxisAxwGfAPZeuPwBmIpnNsWIl6buey3W9s9eEgJG9-Xu7FweBVtG0My1Q04k6HH1yaaETLEhK3HBl-CcXk7403w1YUzUxfG8mr2YQzufkr4V_APMONVcMHPx-jTYFyCk-d4hO7Oz25Xl9X698XV6ue66hgXuWoUU6AaslSqF73smKkJH4BxDgOp-5ZJIaAZTAl1S8TACVNLXobGhap7JvgR-vGk-zi1I_Qd-ByN04_RjibOOhir31e83er7sNOUipoqVheFr88KMfydIGU92tSBc8ZDmJLmlBaKKLFv9u0J7cqgUoThtQ8lem-l3lupKd_nsuBf3v7tFX4xjv8H46acHw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3112530844</pqid></control><display><type>article</type><title>Normative Profile of Retinal Nerve Fiber Layer Thickness and Lamina Cribrosa-Related Parameters in a Healthy Non-Glaucoma Cynomolgus Monkey Colony</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Wu, Jian ; Li, Ruyue ; Zhu, Sirui ; Chen, Kezhe ; Lin, Caixia ; Tian, Jiaxin ; Pan, Lijie ; Liu, Hongyi ; Jia, Xu ; Yu, Ziyu ; Li, Zhidong ; Zhu, Yingting ; Liu, Wei ; Yang, Chenlong ; Wong, Chiwai ; Wang, Ningli ; Zhuo, Yehong</creator><creatorcontrib>Wu, Jian ; Li, Ruyue ; Zhu, Sirui ; Chen, Kezhe ; Lin, Caixia ; Tian, Jiaxin ; Pan, Lijie ; Liu, Hongyi ; Jia, Xu ; Yu, Ziyu ; Li, Zhidong ; Zhu, Yingting ; Liu, Wei ; Yang, Chenlong ; Wong, Chiwai ; Wang, Ningli ; Zhuo, Yehong ; Non-Human Primate Eye Study Group ; for the Non-Human Primate Eye Study Group</creatorcontrib><description>The purpose of this study was to investigate the normal range of ophthalmic parameters and the correlations between systematic and ocular parameters and retinal nerve fiber layer (RNFL) thickness among a healthy non-glaucoma cynomolgus monkey colony.
All included monkeys were given detailed ophthalmic examinations, including anterior and posterior segments. Furthermore, univariate and multivariate linear regression models were conducted to estimate the relationship between systemic and ophthalmic parameters and global RNFL thickness.
A total of 349 non-glaucoma monkeys (18.69 ± 2.88 years old) were collected. The global RNFL thickness was 94.61 ± 10.13 µm, and sex-specific differences existed in all sectors. The decreasing trend of RNFL is as follows: inferotemporal, superotemporal, inferonasal, superonasal, temporal, and nasal. For lamina cribrosa (LC)-related parameters, cup depth (P < 0.01), LC thickness (P = 0.014), and Bruch's membrane opening (BMO) - minimum rim width 2 (P = 0.002) were greater in the male group. However, LC depth (P = 0.02), anterior laminar insertion depth-1 (P = 0.009), and mean anterior laminar insertion depth (P = 0.029) of female monkeys were greater than those of male monkeys. In multivariate linear regression, only older age was significantly related to reduced global RNFL thickness (P < 0.001).
Our findings suggest the differences in RNFL thickness distribution and sex between non-glaucoma cynomolgus monkeys and humans. Therefore, the impact of this difference on outcomes should be fully considered in laboratory animal studies. Our findings are also significant in terms of developing a normative optical coherence tomography (OCT) database in nonhuman primates (NHPs).
We found that the differences in RNFL thickness distribution and sex between non-glaucoma cynomolgus monkey colonies and humans should be thoroughly taken into account in laboratory animal studies.</description><identifier>ISSN: 2164-2591</identifier><identifier>EISSN: 2164-2591</identifier><identifier>DOI: 10.1167/tvst.13.10.6</identifier><identifier>PMID: 39361317</identifier><language>eng</language><publisher>United States: The Association for Research in Vision and Ophthalmology</publisher><subject>Animals ; Female ; Glaucoma ; Intraocular Pressure - physiology ; Macaca fascicularis - anatomy & histology ; Male ; Nerve Fibers ; Optic Disk - anatomy & histology ; Reference Values ; Retinal Ganglion Cells - cytology ; Tomography, Optical Coherence - methods</subject><ispartof>Translational vision science & technology, 2024-10, Vol.13 (10), p.6</ispartof><rights>Copyright 2024 The Authors 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c234t-9828e890788d4d6c2a503fe233ef05db2644e9fa6445b04f3028731673485d243</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11451825/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11451825/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39361317$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wu, Jian</creatorcontrib><creatorcontrib>Li, Ruyue</creatorcontrib><creatorcontrib>Zhu, Sirui</creatorcontrib><creatorcontrib>Chen, Kezhe</creatorcontrib><creatorcontrib>Lin, Caixia</creatorcontrib><creatorcontrib>Tian, Jiaxin</creatorcontrib><creatorcontrib>Pan, Lijie</creatorcontrib><creatorcontrib>Liu, Hongyi</creatorcontrib><creatorcontrib>Jia, Xu</creatorcontrib><creatorcontrib>Yu, Ziyu</creatorcontrib><creatorcontrib>Li, Zhidong</creatorcontrib><creatorcontrib>Zhu, Yingting</creatorcontrib><creatorcontrib>Liu, Wei</creatorcontrib><creatorcontrib>Yang, Chenlong</creatorcontrib><creatorcontrib>Wong, Chiwai</creatorcontrib><creatorcontrib>Wang, Ningli</creatorcontrib><creatorcontrib>Zhuo, Yehong</creatorcontrib><creatorcontrib>Non-Human Primate Eye Study Group</creatorcontrib><creatorcontrib>for the Non-Human Primate Eye Study Group</creatorcontrib><title>Normative Profile of Retinal Nerve Fiber Layer Thickness and Lamina Cribrosa-Related Parameters in a Healthy Non-Glaucoma Cynomolgus Monkey Colony</title><title>Translational vision science & technology</title><addtitle>Transl Vis Sci Technol</addtitle><description>The purpose of this study was to investigate the normal range of ophthalmic parameters and the correlations between systematic and ocular parameters and retinal nerve fiber layer (RNFL) thickness among a healthy non-glaucoma cynomolgus monkey colony.
All included monkeys were given detailed ophthalmic examinations, including anterior and posterior segments. Furthermore, univariate and multivariate linear regression models were conducted to estimate the relationship between systemic and ophthalmic parameters and global RNFL thickness.
A total of 349 non-glaucoma monkeys (18.69 ± 2.88 years old) were collected. The global RNFL thickness was 94.61 ± 10.13 µm, and sex-specific differences existed in all sectors. The decreasing trend of RNFL is as follows: inferotemporal, superotemporal, inferonasal, superonasal, temporal, and nasal. For lamina cribrosa (LC)-related parameters, cup depth (P < 0.01), LC thickness (P = 0.014), and Bruch's membrane opening (BMO) - minimum rim width 2 (P = 0.002) were greater in the male group. However, LC depth (P = 0.02), anterior laminar insertion depth-1 (P = 0.009), and mean anterior laminar insertion depth (P = 0.029) of female monkeys were greater than those of male monkeys. In multivariate linear regression, only older age was significantly related to reduced global RNFL thickness (P < 0.001).
Our findings suggest the differences in RNFL thickness distribution and sex between non-glaucoma cynomolgus monkeys and humans. Therefore, the impact of this difference on outcomes should be fully considered in laboratory animal studies. Our findings are also significant in terms of developing a normative optical coherence tomography (OCT) database in nonhuman primates (NHPs).
We found that the differences in RNFL thickness distribution and sex between non-glaucoma cynomolgus monkey colonies and humans should be thoroughly taken into account in laboratory animal studies.</description><subject>Animals</subject><subject>Female</subject><subject>Glaucoma</subject><subject>Intraocular Pressure - physiology</subject><subject>Macaca fascicularis - anatomy & histology</subject><subject>Male</subject><subject>Nerve Fibers</subject><subject>Optic Disk - anatomy & histology</subject><subject>Reference Values</subject><subject>Retinal Ganglion Cells - cytology</subject><subject>Tomography, Optical Coherence - methods</subject><issn>2164-2591</issn><issn>2164-2591</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkU1v3CAQhlHVqomS3HKuOPZQb_kyi09VtcqXtN1GUXJG2B5naTCkgFfy3-gvLqt8KOHAMMzDO2hehE4pWVAql9_zLuUF5YuSyw_okFEpKlY39OOb8wE6SekPKUuqWgj5GR3whkvK6fIQ_duEOJpsd4CvYxisAxwGfAPZeuPwBmIpnNsWIl6buey3W9s9eEgJG9-Xu7FweBVtG0My1Q04k6HH1yaaETLEhK3HBl-CcXk7403w1YUzUxfG8mr2YQzufkr4V_APMONVcMHPx-jTYFyCk-d4hO7Oz25Xl9X698XV6ue66hgXuWoUU6AaslSqF73smKkJH4BxDgOp-5ZJIaAZTAl1S8TACVNLXobGhap7JvgR-vGk-zi1I_Qd-ByN04_RjibOOhir31e83er7sNOUipoqVheFr88KMfydIGU92tSBc8ZDmJLmlBaKKLFv9u0J7cqgUoThtQ8lem-l3lupKd_nsuBf3v7tFX4xjv8H46acHw</recordid><startdate>20241001</startdate><enddate>20241001</enddate><creator>Wu, Jian</creator><creator>Li, Ruyue</creator><creator>Zhu, Sirui</creator><creator>Chen, Kezhe</creator><creator>Lin, Caixia</creator><creator>Tian, Jiaxin</creator><creator>Pan, Lijie</creator><creator>Liu, Hongyi</creator><creator>Jia, Xu</creator><creator>Yu, Ziyu</creator><creator>Li, Zhidong</creator><creator>Zhu, Yingting</creator><creator>Liu, Wei</creator><creator>Yang, Chenlong</creator><creator>Wong, Chiwai</creator><creator>Wang, Ningli</creator><creator>Zhuo, Yehong</creator><general>The Association for Research in Vision and Ophthalmology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20241001</creationdate><title>Normative Profile of Retinal Nerve Fiber Layer Thickness and Lamina Cribrosa-Related Parameters in a Healthy Non-Glaucoma Cynomolgus Monkey Colony</title><author>Wu, Jian ; Li, Ruyue ; Zhu, Sirui ; Chen, Kezhe ; Lin, Caixia ; Tian, Jiaxin ; Pan, Lijie ; Liu, Hongyi ; Jia, Xu ; Yu, Ziyu ; Li, Zhidong ; Zhu, Yingting ; Liu, Wei ; Yang, Chenlong ; Wong, Chiwai ; Wang, Ningli ; Zhuo, Yehong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c234t-9828e890788d4d6c2a503fe233ef05db2644e9fa6445b04f3028731673485d243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Animals</topic><topic>Female</topic><topic>Glaucoma</topic><topic>Intraocular Pressure - physiology</topic><topic>Macaca fascicularis - anatomy & histology</topic><topic>Male</topic><topic>Nerve Fibers</topic><topic>Optic Disk - anatomy & histology</topic><topic>Reference Values</topic><topic>Retinal Ganglion Cells - cytology</topic><topic>Tomography, Optical Coherence - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wu, Jian</creatorcontrib><creatorcontrib>Li, Ruyue</creatorcontrib><creatorcontrib>Zhu, Sirui</creatorcontrib><creatorcontrib>Chen, Kezhe</creatorcontrib><creatorcontrib>Lin, Caixia</creatorcontrib><creatorcontrib>Tian, Jiaxin</creatorcontrib><creatorcontrib>Pan, Lijie</creatorcontrib><creatorcontrib>Liu, Hongyi</creatorcontrib><creatorcontrib>Jia, Xu</creatorcontrib><creatorcontrib>Yu, Ziyu</creatorcontrib><creatorcontrib>Li, Zhidong</creatorcontrib><creatorcontrib>Zhu, Yingting</creatorcontrib><creatorcontrib>Liu, Wei</creatorcontrib><creatorcontrib>Yang, Chenlong</creatorcontrib><creatorcontrib>Wong, Chiwai</creatorcontrib><creatorcontrib>Wang, Ningli</creatorcontrib><creatorcontrib>Zhuo, Yehong</creatorcontrib><creatorcontrib>Non-Human Primate Eye Study Group</creatorcontrib><creatorcontrib>for the Non-Human Primate Eye Study Group</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Translational vision science & technology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, Jian</au><au>Li, Ruyue</au><au>Zhu, Sirui</au><au>Chen, Kezhe</au><au>Lin, Caixia</au><au>Tian, Jiaxin</au><au>Pan, Lijie</au><au>Liu, Hongyi</au><au>Jia, Xu</au><au>Yu, Ziyu</au><au>Li, Zhidong</au><au>Zhu, Yingting</au><au>Liu, Wei</au><au>Yang, Chenlong</au><au>Wong, Chiwai</au><au>Wang, Ningli</au><au>Zhuo, Yehong</au><aucorp>Non-Human Primate Eye Study Group</aucorp><aucorp>for the Non-Human Primate Eye Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Normative Profile of Retinal Nerve Fiber Layer Thickness and Lamina Cribrosa-Related Parameters in a Healthy Non-Glaucoma Cynomolgus Monkey Colony</atitle><jtitle>Translational vision science & technology</jtitle><addtitle>Transl Vis Sci Technol</addtitle><date>2024-10-01</date><risdate>2024</risdate><volume>13</volume><issue>10</issue><spage>6</spage><pages>6-</pages><issn>2164-2591</issn><eissn>2164-2591</eissn><abstract>The purpose of this study was to investigate the normal range of ophthalmic parameters and the correlations between systematic and ocular parameters and retinal nerve fiber layer (RNFL) thickness among a healthy non-glaucoma cynomolgus monkey colony.
All included monkeys were given detailed ophthalmic examinations, including anterior and posterior segments. Furthermore, univariate and multivariate linear regression models were conducted to estimate the relationship between systemic and ophthalmic parameters and global RNFL thickness.
A total of 349 non-glaucoma monkeys (18.69 ± 2.88 years old) were collected. The global RNFL thickness was 94.61 ± 10.13 µm, and sex-specific differences existed in all sectors. The decreasing trend of RNFL is as follows: inferotemporal, superotemporal, inferonasal, superonasal, temporal, and nasal. For lamina cribrosa (LC)-related parameters, cup depth (P < 0.01), LC thickness (P = 0.014), and Bruch's membrane opening (BMO) - minimum rim width 2 (P = 0.002) were greater in the male group. However, LC depth (P = 0.02), anterior laminar insertion depth-1 (P = 0.009), and mean anterior laminar insertion depth (P = 0.029) of female monkeys were greater than those of male monkeys. In multivariate linear regression, only older age was significantly related to reduced global RNFL thickness (P < 0.001).
Our findings suggest the differences in RNFL thickness distribution and sex between non-glaucoma cynomolgus monkeys and humans. Therefore, the impact of this difference on outcomes should be fully considered in laboratory animal studies. Our findings are also significant in terms of developing a normative optical coherence tomography (OCT) database in nonhuman primates (NHPs).
We found that the differences in RNFL thickness distribution and sex between non-glaucoma cynomolgus monkey colonies and humans should be thoroughly taken into account in laboratory animal studies.</abstract><cop>United States</cop><pub>The Association for Research in Vision and Ophthalmology</pub><pmid>39361317</pmid><doi>10.1167/tvst.13.10.6</doi><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Animals Female Glaucoma Intraocular Pressure - physiology Macaca fascicularis - anatomy & histology Male Nerve Fibers Optic Disk - anatomy & histology Reference Values Retinal Ganglion Cells - cytology Tomography, Optical Coherence - methods |
| title | Normative Profile of Retinal Nerve Fiber Layer Thickness and Lamina Cribrosa-Related Parameters in a Healthy Non-Glaucoma Cynomolgus Monkey Colony |
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