Lactate and base excess (BE) as markers of hypoperfusion and mortality in traumatic hemorrhagic shock in patients undergoing Damage Control: a historical cohort
hemorrhagic shock is a significant cause of trauma-related deaths in Brazil and worldwide. This study aims to compare BE and lactate values at ICU admission and twenty-four hours after in identifying tissue hypoperfusion and mortality. examines a historical cohort of trauma patients over eitheen yea...
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| Veröffentlicht in: | Revista do Colegio Brasileiro de Cirurgioes 2024, Vol.51, p.e20243699 |
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| creator | Reese, Fernanda Baeumle Hubert, Flavia Castanho Cosentino, Mariana Bruinje Oliveira, Mirella Cristine DE Réa Neto, Álvaro Bernardelli, Rafaella Stradiotto Matias, Jorge Eduardo |
| description | hemorrhagic shock is a significant cause of trauma-related deaths in Brazil and worldwide. This study aims to compare BE and lactate values at ICU admission and twenty-four hours after in identifying tissue hypoperfusion and mortality.
examines a historical cohort of trauma patients over eitheen years old submittet to damage control resuscitation approch upon hospital admission and were then admitted to the ICU. We collected and analyzed ISS, mechanism and type of trauma, need for renal replacement therapy, massive transfusion. BE, lactate, pH, bicarbonate at ICU admission and twenty-four hours later, and mortality data. The patients were grouped based on their BE values (≥-6 and |
| doi_str_mv | 10.1590/0100-6991e-20243699-en |
| format | Article |
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examines a historical cohort of trauma patients over eitheen years old submittet to damage control resuscitation approch upon hospital admission and were then admitted to the ICU. We collected and analyzed ISS, mechanism and type of trauma, need for renal replacement therapy, massive transfusion. BE, lactate, pH, bicarbonate at ICU admission and twenty-four hours later, and mortality data. The patients were grouped based on their BE values (≥-6 and <-6mmol/L), which were previously identified in the literature as predictors of severity. They were subsequently redivided using the most accurate values found in this sample. In addition to performing multivariate binary logistic regression. The data were compared using several statistical tests due to diversity and according to the indication for each variable.
there were significant changes in perfusion upon admission to the Intensive Care Unit. BE is a statistically significant value for predicting mortality, as determined by using values from previous literature and from this study.
the results demonstrate the importance of monitoring BE levels in the prediction of ICU mortality. BE proves to be a valuable bedside marker with quick results and wide availability.</description><identifier>ISSN: 0100-6991</identifier><identifier>EISSN: 1809-4546</identifier><identifier>DOI: 10.1590/0100-6991e-20243699-en</identifier><identifier>PMID: 38985036</identifier><language>eng ; por</language><publisher>Brazil: Colégio Brasileiro de Cirurgiões</publisher><subject>Acidosis, Lactic ; Adult ; Biomarkers - blood ; Blood Gas Analysis ; Cohort Studies ; Female ; Hemorrhagic ; Humans ; Intensive Care Units ; Lactic Acid - blood ; Male ; Middle Aged ; Multiple Trauma ; Original ; Shock ; Shock, Hemorrhagic - blood ; Shock, Hemorrhagic - mortality</subject><ispartof>Revista do Colegio Brasileiro de Cirurgioes, 2024, Vol.51, p.e20243699</ispartof><rights>2024 Revista do Colégio Brasileiro de Cirurgiões 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c312n-7582bbbb998a1bcea3b8340091ff9e4a40cb9968d96db12a379cce81651c52323</cites><orcidid>0000-0002-6731-3664 ; 0000-0001-6377-8870 ; 0000-0001-5524-0907 ; 0000-0002-7653-9710 ; 0009-0006-7472-8637 ; 0000-0002-4613-0834 ; 0000-0001-8086-1203</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11449522/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11449522/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38985036$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Reese, Fernanda Baeumle</creatorcontrib><creatorcontrib>Hubert, Flavia Castanho</creatorcontrib><creatorcontrib>Cosentino, Mariana Bruinje</creatorcontrib><creatorcontrib>Oliveira, Mirella Cristine DE</creatorcontrib><creatorcontrib>Réa Neto, Álvaro</creatorcontrib><creatorcontrib>Bernardelli, Rafaella Stradiotto</creatorcontrib><creatorcontrib>Matias, Jorge Eduardo</creatorcontrib><title>Lactate and base excess (BE) as markers of hypoperfusion and mortality in traumatic hemorrhagic shock in patients undergoing Damage Control: a historical cohort</title><title>Revista do Colegio Brasileiro de Cirurgioes</title><addtitle>Rev Col Bras Cir</addtitle><description>hemorrhagic shock is a significant cause of trauma-related deaths in Brazil and worldwide. This study aims to compare BE and lactate values at ICU admission and twenty-four hours after in identifying tissue hypoperfusion and mortality.
examines a historical cohort of trauma patients over eitheen years old submittet to damage control resuscitation approch upon hospital admission and were then admitted to the ICU. We collected and analyzed ISS, mechanism and type of trauma, need for renal replacement therapy, massive transfusion. BE, lactate, pH, bicarbonate at ICU admission and twenty-four hours later, and mortality data. The patients were grouped based on their BE values (≥-6 and <-6mmol/L), which were previously identified in the literature as predictors of severity. They were subsequently redivided using the most accurate values found in this sample. In addition to performing multivariate binary logistic regression. The data were compared using several statistical tests due to diversity and according to the indication for each variable.
there were significant changes in perfusion upon admission to the Intensive Care Unit. BE is a statistically significant value for predicting mortality, as determined by using values from previous literature and from this study.
the results demonstrate the importance of monitoring BE levels in the prediction of ICU mortality. BE proves to be a valuable bedside marker with quick results and wide availability.</description><subject>Acidosis, Lactic</subject><subject>Adult</subject><subject>Biomarkers - blood</subject><subject>Blood Gas Analysis</subject><subject>Cohort Studies</subject><subject>Female</subject><subject>Hemorrhagic</subject><subject>Humans</subject><subject>Intensive Care Units</subject><subject>Lactic Acid - blood</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multiple Trauma</subject><subject>Original</subject><subject>Shock</subject><subject>Shock, Hemorrhagic - blood</subject><subject>Shock, Hemorrhagic - mortality</subject><issn>0100-6991</issn><issn>1809-4546</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>DOA</sourceid><recordid>eNpVksFu1DAQhiMEotvCK1Q-wiHFEzvZmAuCpUCllbjA2Zo4k8RtYkd2FrFvw6Pi3aUr6otH_v1_9mj-LLsGfgOl4u84cJ5XSgHlBS-kSGVO7lm2gpqrXJayep6tzpcusssY7zmXApR4mV2IWtUlF9Uq-7NFs-BCDF3LGozE6LehGNmbT7dvGUY2YXigEJnv2LCf_Uyh20Xr3dEw-bDgaJc9s44tAXcTLtawgZIQBuxTHQdvHg7ynCRyS2Q711LovXU9-4wT9sQ23i3Bj-8ZssHGxQdrcGTGDwn_KnvR4Rjp9b_9Kvv55fbH5lu-_f71bvNxmxsBhcvXZV00aSlVIzSGUDS1kJwr6DpFEiU3SavqVlVtAwWKtTKGaqhKMGUhCnGV3Z24rcd7PQebGt9rj1YfD3zoNYbU3Ei6hSZh15yUaSXvCEF0AKYSsFZNxXlifTix5l0zUWtS2wHHJ9CnirOD7v0vDSClKovDb6oTwQQfY6DubAauDwHQh9nqYwD0YwA0uWS8_v_ps-1x4uIvXbyxGA</recordid><startdate>202401</startdate><enddate>202401</enddate><creator>Reese, Fernanda Baeumle</creator><creator>Hubert, Flavia Castanho</creator><creator>Cosentino, Mariana Bruinje</creator><creator>Oliveira, Mirella Cristine DE</creator><creator>Réa Neto, Álvaro</creator><creator>Bernardelli, Rafaella Stradiotto</creator><creator>Matias, Jorge Eduardo</creator><general>Colégio Brasileiro de Cirurgiões</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-6731-3664</orcidid><orcidid>https://orcid.org/0000-0001-6377-8870</orcidid><orcidid>https://orcid.org/0000-0001-5524-0907</orcidid><orcidid>https://orcid.org/0000-0002-7653-9710</orcidid><orcidid>https://orcid.org/0009-0006-7472-8637</orcidid><orcidid>https://orcid.org/0000-0002-4613-0834</orcidid><orcidid>https://orcid.org/0000-0001-8086-1203</orcidid></search><sort><creationdate>202401</creationdate><title>Lactate and base excess (BE) as markers of hypoperfusion and mortality in traumatic hemorrhagic shock in patients undergoing Damage Control: a historical cohort</title><author>Reese, Fernanda Baeumle ; Hubert, Flavia Castanho ; Cosentino, Mariana Bruinje ; Oliveira, Mirella Cristine DE ; Réa Neto, Álvaro ; Bernardelli, Rafaella Stradiotto ; Matias, Jorge Eduardo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c312n-7582bbbb998a1bcea3b8340091ff9e4a40cb9968d96db12a379cce81651c52323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng ; por</language><creationdate>2024</creationdate><topic>Acidosis, Lactic</topic><topic>Adult</topic><topic>Biomarkers - blood</topic><topic>Blood Gas Analysis</topic><topic>Cohort Studies</topic><topic>Female</topic><topic>Hemorrhagic</topic><topic>Humans</topic><topic>Intensive Care Units</topic><topic>Lactic Acid - blood</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multiple Trauma</topic><topic>Original</topic><topic>Shock</topic><topic>Shock, Hemorrhagic - blood</topic><topic>Shock, Hemorrhagic - mortality</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Reese, Fernanda Baeumle</creatorcontrib><creatorcontrib>Hubert, Flavia Castanho</creatorcontrib><creatorcontrib>Cosentino, Mariana Bruinje</creatorcontrib><creatorcontrib>Oliveira, Mirella Cristine DE</creatorcontrib><creatorcontrib>Réa Neto, Álvaro</creatorcontrib><creatorcontrib>Bernardelli, Rafaella Stradiotto</creatorcontrib><creatorcontrib>Matias, Jorge Eduardo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Revista do Colegio Brasileiro de Cirurgioes</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Reese, Fernanda Baeumle</au><au>Hubert, Flavia Castanho</au><au>Cosentino, Mariana Bruinje</au><au>Oliveira, Mirella Cristine DE</au><au>Réa Neto, Álvaro</au><au>Bernardelli, Rafaella Stradiotto</au><au>Matias, Jorge Eduardo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lactate and base excess (BE) as markers of hypoperfusion and mortality in traumatic hemorrhagic shock in patients undergoing Damage Control: a historical cohort</atitle><jtitle>Revista do Colegio Brasileiro de Cirurgioes</jtitle><addtitle>Rev Col Bras Cir</addtitle><date>2024-01</date><risdate>2024</risdate><volume>51</volume><spage>e20243699</spage><pages>e20243699-</pages><issn>0100-6991</issn><eissn>1809-4546</eissn><abstract>hemorrhagic shock is a significant cause of trauma-related deaths in Brazil and worldwide. This study aims to compare BE and lactate values at ICU admission and twenty-four hours after in identifying tissue hypoperfusion and mortality.
examines a historical cohort of trauma patients over eitheen years old submittet to damage control resuscitation approch upon hospital admission and were then admitted to the ICU. We collected and analyzed ISS, mechanism and type of trauma, need for renal replacement therapy, massive transfusion. BE, lactate, pH, bicarbonate at ICU admission and twenty-four hours later, and mortality data. The patients were grouped based on their BE values (≥-6 and <-6mmol/L), which were previously identified in the literature as predictors of severity. They were subsequently redivided using the most accurate values found in this sample. In addition to performing multivariate binary logistic regression. The data were compared using several statistical tests due to diversity and according to the indication for each variable.
there were significant changes in perfusion upon admission to the Intensive Care Unit. BE is a statistically significant value for predicting mortality, as determined by using values from previous literature and from this study.
the results demonstrate the importance of monitoring BE levels in the prediction of ICU mortality. BE proves to be a valuable bedside marker with quick results and wide availability.</abstract><cop>Brazil</cop><pub>Colégio Brasileiro de Cirurgiões</pub><pmid>38985036</pmid><doi>10.1590/0100-6991e-20243699-en</doi><orcidid>https://orcid.org/0000-0002-6731-3664</orcidid><orcidid>https://orcid.org/0000-0001-6377-8870</orcidid><orcidid>https://orcid.org/0000-0001-5524-0907</orcidid><orcidid>https://orcid.org/0000-0002-7653-9710</orcidid><orcidid>https://orcid.org/0009-0006-7472-8637</orcidid><orcidid>https://orcid.org/0000-0002-4613-0834</orcidid><orcidid>https://orcid.org/0000-0001-8086-1203</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Acidosis, Lactic Adult Biomarkers - blood Blood Gas Analysis Cohort Studies Female Hemorrhagic Humans Intensive Care Units Lactic Acid - blood Male Middle Aged Multiple Trauma Original Shock Shock, Hemorrhagic - blood Shock, Hemorrhagic - mortality |
| title | Lactate and base excess (BE) as markers of hypoperfusion and mortality in traumatic hemorrhagic shock in patients undergoing Damage Control: a historical cohort |
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