A highly sensitive reporter system to monitor endogenous YAP1/TAZ activity and its application in various human cells

The activation of yes‐associated protein 1 (YAP1) and transcriptional co‐activator with PDZ‐binding motif (TAZ) has been implicated in both regeneration and tumorigenesis, thus representing a double‐edged sword in tissue homeostasis. However, how the activity of YAP1/TAZ is regulated or what leads t...

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Veröffentlicht in:	Cancer science 2024-10, Vol.115 (10), p.3370-3383
Hauptverfasser:	Hikasa, Hiroki, Kawahara, Kohichi, Inui, Masako, Yasuki, Yukichika, Yamashita, Keita, Otsubo, Kohei, Kitajima, Shojiro, Nishio, Miki, Arima, Kazunari, Endo, Motoyoshi, Taira, Masanori, Suzuki, Akira
Format:	Artikel
Sprache:	eng
Schlagworte:	Adapter proteins Adaptor Proteins, Signal Transducing - metabolism beta Catenin - metabolism Cancer Catenin Cell activation Cell growth cell‐based screening Cytokines Genes, Reporter Genotoxicity HEK293 Cells highly sensitive reporter system Hippo‐YAP1/TAZ pathway Homeostasis Humans Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Ionophores Janus kinase Kinases lentivirus Ligands Liver Lungs Medical prognosis NF-kappa B - metabolism Original ORIGINAL ARTICLE Phosphoproteins - metabolism Phosphorylation Response Elements Signal Transduction Trans-Activators - metabolism Transcription factors Transcription Factors - metabolism Transcriptional Coactivator with PDZ-Binding Motif Proteins - metabolism Tumorigenesis Wnt protein YAP-Signaling Proteins - metabolism YAP1/TAZ modulators Yes-associated protein
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