CircMAN1A2_009 facilitates YBX1 nuclear localization to induce GLO1 activation for cervical adenocarcinoma cell growth

The molecular mechanisms driving the development of cervical adenocarcinoma (CADC) and optimal patient management strategies remain elusive. In this study, we have identified circMAN1A2_009 as an oncogenic circular RNA (circRNA) in CADC. Clinically, circMAN1A2_009 showed significant upregulation in...

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Veröffentlicht in:	Cancer science 2024-10, Vol.115 (10), p.3273-3287
Hauptverfasser:	Huang, Yongjie, Wei, Xinyi, Tu, Mengyan, Lu, Weiguo, Xu, Junfen
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Adenocarcinoma - genetics Adenocarcinoma - metabolism Adenocarcinoma - pathology Animals Apoptosis Apoptosis - genetics Binding sites Bioinformatics Cell activation Cell growth Cell Line, Tumor Cell Nucleus - metabolism Cell Proliferation - genetics Cell viability cervical adenocarcinoma Cervical cancer circRNA Circular RNA Female Gene Expression Regulation, Neoplastic Humans Lactoylglutathione Lyase - genetics Lactoylglutathione Lyase - metabolism Localization Mass spectrometry Mice Middle Aged Molecular modelling nuclear localization Original Phosphorylation Proteins Reactive oxygen species Reactive Oxygen Species - metabolism RNA, Circular - genetics RNA, Circular - metabolism Scientific imaging Signal transduction transcriptional activation Up-Regulation Uterine Cervical Neoplasms - genetics Uterine Cervical Neoplasms - metabolism Uterine Cervical Neoplasms - pathology Y-Box-Binding Protein 1 - genetics Y-Box-Binding Protein 1 - metabolism
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