Efficacy and safety of lenvatinib combined with anti-PD-1 antibodies plus GEMOX chemotherapy as non-first-line systemic therapy in advanced gallbladder cancer

Background Lenvatinib, programmed cell death 1 (PD-1) antibodies, and gemcitabine and oxaliplatin (GEMOX) chemotherapy have shown significant antitumor activity as first-line therapy against biliary tract cancer. This study evaluated their efficacy and safety as non-first-line therapy in advanced ga...

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Veröffentlicht in:	Cancer Immunology, Immunotherapy : CII Immunotherapy : CII, 2024-10, Vol.73 (12), p.240, Article 240
Hauptverfasser:	Tan, Yang, Liu, Kai, Zhu, Chengpei, Wang, Shanshan, Wang, Yunchao, Xue, Jingnan, Ning, Cong, Zhang, Nan, Chao, Jiashuo, Zhang, Longhao, Long, Junyu, Yang, Xiaobo, Zeng, Daobing, Zhao, Lijin, Zhao, Haitao
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Alanine transaminase Antibodies Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Antitumor activity Apoptosis Aspartate transaminase Biliary tract Biliary tract diseases Cancer Research Cancer therapies Cell death Chemotherapy Deoxycytidine - administration & dosage Deoxycytidine - analogs & derivatives Deoxycytidine - therapeutic use Diarrhea Disease control Female Gallbladder cancer Gallbladder Neoplasms - drug therapy Gallbladder Neoplasms - mortality Gemcitabine Humans Immune Checkpoint Inhibitors - administration & dosage Immune Checkpoint Inhibitors - adverse effects Immune Checkpoint Inhibitors - therapeutic use Immunology Leukocytes (neutrophilic) Lymphocytes Male Medicine Medicine & Public Health Middle Aged Myelosuppression Oncology Organoplatinum Compounds Oxaliplatin Patients PD-1 protein PD-L1 protein Phenylurea Compounds - administration & dosage Phenylurea Compounds - adverse effects Phenylurea Compounds - therapeutic use Programmed Cell Death 1 Receptor - antagonists & inhibitors Quinolines - administration & dosage Quinolines - adverse effects Quinolines - therapeutic use Retrospective Studies
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