Regulation of primary cilia disassembly through HUWE1-mediated TTBK2 degradation plays a crucial role in cerebellar development and medulloblastoma growth

Development of the cerebellum requires precise regulation of granule neuron progenitor (GNP) proliferation. Although it is known that primary cilia are necessary to support GNP proliferation, the exact molecular mechanism governing primary cilia dynamics within GNPs remains elusive. Here, we establi...

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Veröffentlicht in:	Cell death and differentiation 2024-10, Vol.31 (10), p.1349-1361
Hauptverfasser:	Lin, I-Hsuan, Li, Yue-Ru, Chang, Chia-Hsiang, Cheng, Yu-Wen, Wang, Yu-Ting, Tsai, Yu-Shuen, Lin, Pei-Yi, Kao, Chien-Han, Su, Ting-Yu, Hsu, Chih-Sin, Tung, Chien-Yi, Hsu, Pang-Hung, Ayrault, Olivier, Chung, Bon-chu, Tsai, Jin-Wu, Wang, Won-Jing
Format:	Artikel
Sprache:	eng
Schlagworte:	13/109 13/89 14/19 14/34 14/63 38/1 38/23 38/39 38/91 42/70 631/337 631/67/1922 631/80 82 96 96/31 96/34 Animals Apoptosis Biochemistry Biomedical and Life Sciences Cancer Cell Biology Cell cycle Cell Cycle Analysis Cell Differentiation Cell Proliferation Cerebellar Neoplasms - genetics Cerebellar Neoplasms - metabolism Cerebellar Neoplasms - pathology Cerebellum Cerebellum - metabolism Cilia Cilia - metabolism Hedgehog protein Hedgehog Proteins - metabolism Humans Huwe1 protein Kinases Life Sciences Medulloblastoma Medulloblastoma - genetics Medulloblastoma - metabolism Medulloblastoma - pathology Mice Molecular biology Molecular modelling Neural Stem Cells - metabolism Postpartum period Protein Serine-Threonine Kinases - genetics Protein Serine-Threonine Kinases - metabolism Research centers Stem Cells Tau protein Therapeutic targets Tubulin Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism Ubiquitin-protein ligase Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism
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