The Role of Zinc on Liver Fibrosis by Modulating ZIP14 Expression Throughout Epigenetic Regulatory Mechanisms

Zinc plays a pivotal role in tissue regeneration and maintenance being as a central cofactor in a plethora of enzymatic activities. Hypozincemia is commonly seen with chronic liver disease and is associated with an increased risk of liver fibrosis development and hepatocellular carcinoma. Previously...

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Veröffentlicht in:	Biological trace element research 2024-11, Vol.202 (11), p.5094-5105
Hauptverfasser:	Aksoy-Ozer, Zeynep Busra, Bitirim, Ceylan Verda, Turan, Belma, Akcali, Kamil Can
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Animals Binding Biochemistry Biomedical and Life Sciences Biotechnology Carbon Tetrachloride Cation Transport Proteins - genetics Cation Transport Proteins - metabolism Chlorides - metabolism Chlorides - pharmacology Chromatin Deacetylation DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Enzymatic activity Enzyme activity Epigenesis, Genetic - drug effects Epigenetics Fibrosis Heavy metals Hepatocellular carcinoma Hepatocytes Hepatocytes - drug effects Hepatocytes - metabolism Histone deacetylase Histone Deacetylases - metabolism Histones Immunoprecipitation Intracellular Life Sciences Liver Liver cirrhosis Liver Cirrhosis - chemically induced Liver Cirrhosis - drug therapy Liver Cirrhosis - metabolism Liver Cirrhosis - pathology Liver diseases Male Mice Mice, Inbred C57BL Neoplasms Nutrition Oncology Promoter Regions, Genetic Promoters Regeneration (biological) Regeneration (physiology) Regulatory mechanisms (biology) Smooth muscle Tissue engineering Transcription Factor MTF-1 Transcription Factors - genetics Transcription Factors - metabolism Zinc Zinc - metabolism Zinc - pharmacology Zinc chloride Zinc Compounds - pharmacology
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