Conformational ensembles in Klebsiella pneumoniae FimH impact uropathogenesis

is an important pathogen causing difficult-to-treat urinary tract infections (UTIs). Over 1.5 million women per year suffer from recurrent UTI, reducing quality of life and causing substantial morbidity and mortality, especially in the hospital setting. Uropathogenic (UPEC) is the most prevalent cau...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2024-09, Vol.121 (39), p.e2409655121
Hauptverfasser:	Lopatto, Edward D B, Pinkner, Jerome S, Sanick, Denise A, Potter, Robert F, Liu, Lily X, Bazán Villicaña, Jesús, Tamadonfar, Kevin O, Ye, Yijun, Zimmerman, Maxwell I, Gualberto, Nathaniel C, Dodson, Karen W, Janetka, James W, Hunstad, David A, Hultgren, Scott J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesins, Bacterial - chemistry Adhesins, Bacterial - genetics Adhesins, Bacterial - metabolism Adhesins, Escherichia coli - chemistry Adhesins, Escherichia coli - genetics Adhesins, Escherichia coli - metabolism Adhesives Affinity Binding Binding Sites Biological Sciences Crystallography Crystallography, X-Ray E coli Female Fimbriae Proteins - chemistry Fimbriae Proteins - genetics Fimbriae Proteins - metabolism Fimbriae, Bacterial - metabolism Gene sequencing Humans Klebsiella Klebsiella Infections - microbiology Klebsiella pneumoniae Klebsiella pneumoniae - genetics Klebsiella pneumoniae - metabolism Mannose Mannose - metabolism Models, Molecular Morbidity Phylogeny Pilin Protein Binding Protein Conformation Protein Domains Quality of life Urinary tract Urinary tract infections Urinary Tract Infections - microbiology Urogenital system
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