The effects of insulin and glucagon on ketone-body turnover
A double-isotope procedure was used to measure the effects of insulin and glucagon on ketone-body production and utilization (i.e. turnover) in the starved rat. Somatostatin was infused during the experiment to suppress the pancreatic release of either hormone. The immediate action of insulin in ter...
Gespeichert in:
| Veröffentlicht in: | Biochemical journal 1984-07, Vol.221 (2), p.439-444 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 444 |
|---|---|
| container_issue | 2 |
| container_start_page | 439 |
| container_title | Biochemical journal |
| container_volume | 221 |
| creator | Reed, W D Baab, P J Hawkins, R L Ozand, P T |
| description | A double-isotope procedure was used to measure the effects of insulin and glucagon on ketone-body production and utilization (i.e. turnover) in the starved rat. Somatostatin was infused during the experiment to suppress the pancreatic release of either hormone. The immediate action of insulin in terms of ketone-body turnover that was most evident was a decreased production of 3-hydroxybutyrate, with no significant change in the turnover of acetoacetate. Similarly, the significant effect of glucagon infusion was to increase the production of 3-hydroxybutyrate, with minimum increase in acetoacetate turnover. The data support a direct effect of both hormones on the distribution of acetyl units derived from fatty acid beta-oxidation. |
| doi_str_mv | 10.1042/bj2210439 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1144056</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>81241133</sourcerecordid><originalsourceid>FETCH-LOGICAL-c370t-29132d0a93904026306169e05f6ae14467451dec041948b2062aef56d3b0579b3</originalsourceid><addsrcrecordid>eNpVkE1Lw0AQhhdRaq0e_AFCToKH6MzuZpMgCFL8goKXel42yaRNTXd1Nyn03xtpKQoDMzAPzwwvY5cItwiS3xUrzodB5EdsjDKFOEt5dszGwJWMFXA8ZWchrABQgoQRGymRCSGzMbufLymiuqayC5Gro8aGvm1sZGwVLdq-NAtno6E-qXOW4sJV26jrvXUb8ufspDZtoIt9n7CP56f59DWevb-8TR9ncSlS6GKeo-AVmFzkw3GuBChUOUFSK0MopUplghWVIDGXWcFBcUN1oipRQJLmhZiwh533qy_WVJVkO29a_eWbtfFb7Uyj_29ss9QLt9E42CFRg-B6L_Duu6fQ6XUTSmpbY8n1QWfIJaIQA3izA0vvQvBUH44g6N-k9SHpgb36-9WB3EcrfgD-Unef</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>81241133</pqid></control><display><type>article</type><title>The effects of insulin and glucagon on ketone-body turnover</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Reed, W D ; Baab, P J ; Hawkins, R L ; Ozand, P T</creator><creatorcontrib>Reed, W D ; Baab, P J ; Hawkins, R L ; Ozand, P T</creatorcontrib><description>A double-isotope procedure was used to measure the effects of insulin and glucagon on ketone-body production and utilization (i.e. turnover) in the starved rat. Somatostatin was infused during the experiment to suppress the pancreatic release of either hormone. The immediate action of insulin in terms of ketone-body turnover that was most evident was a decreased production of 3-hydroxybutyrate, with no significant change in the turnover of acetoacetate. Similarly, the significant effect of glucagon infusion was to increase the production of 3-hydroxybutyrate, with minimum increase in acetoacetate turnover. The data support a direct effect of both hormones on the distribution of acetyl units derived from fatty acid beta-oxidation.</description><identifier>ISSN: 0264-6021</identifier><identifier>EISSN: 1470-8728</identifier><identifier>DOI: 10.1042/bj2210439</identifier><identifier>PMID: 6383348</identifier><language>eng</language><publisher>England</publisher><subject>3-Hydroxybutyric Acid ; Acetoacetates - blood ; Animals ; Blood Glucose - metabolism ; Caprylates - blood ; Female ; Glucagon - blood ; Glucagon - pharmacology ; Hydroxybutyrates - blood ; Insulin - blood ; Insulin - pharmacology ; Ketone Bodies - metabolism ; Male ; Rats ; Rats, Inbred Strains</subject><ispartof>Biochemical journal, 1984-07, Vol.221 (2), p.439-444</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c370t-29132d0a93904026306169e05f6ae14467451dec041948b2062aef56d3b0579b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1144056/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1144056/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6383348$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Reed, W D</creatorcontrib><creatorcontrib>Baab, P J</creatorcontrib><creatorcontrib>Hawkins, R L</creatorcontrib><creatorcontrib>Ozand, P T</creatorcontrib><title>The effects of insulin and glucagon on ketone-body turnover</title><title>Biochemical journal</title><addtitle>Biochem J</addtitle><description>A double-isotope procedure was used to measure the effects of insulin and glucagon on ketone-body production and utilization (i.e. turnover) in the starved rat. Somatostatin was infused during the experiment to suppress the pancreatic release of either hormone. The immediate action of insulin in terms of ketone-body turnover that was most evident was a decreased production of 3-hydroxybutyrate, with no significant change in the turnover of acetoacetate. Similarly, the significant effect of glucagon infusion was to increase the production of 3-hydroxybutyrate, with minimum increase in acetoacetate turnover. The data support a direct effect of both hormones on the distribution of acetyl units derived from fatty acid beta-oxidation.</description><subject>3-Hydroxybutyric Acid</subject><subject>Acetoacetates - blood</subject><subject>Animals</subject><subject>Blood Glucose - metabolism</subject><subject>Caprylates - blood</subject><subject>Female</subject><subject>Glucagon - blood</subject><subject>Glucagon - pharmacology</subject><subject>Hydroxybutyrates - blood</subject><subject>Insulin - blood</subject><subject>Insulin - pharmacology</subject><subject>Ketone Bodies - metabolism</subject><subject>Male</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><issn>0264-6021</issn><issn>1470-8728</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkE1Lw0AQhhdRaq0e_AFCToKH6MzuZpMgCFL8goKXel42yaRNTXd1Nyn03xtpKQoDMzAPzwwvY5cItwiS3xUrzodB5EdsjDKFOEt5dszGwJWMFXA8ZWchrABQgoQRGymRCSGzMbufLymiuqayC5Gro8aGvm1sZGwVLdq-NAtno6E-qXOW4sJV26jrvXUb8ufspDZtoIt9n7CP56f59DWevb-8TR9ncSlS6GKeo-AVmFzkw3GuBChUOUFSK0MopUplghWVIDGXWcFBcUN1oipRQJLmhZiwh533qy_WVJVkO29a_eWbtfFb7Uyj_29ss9QLt9E42CFRg-B6L_Duu6fQ6XUTSmpbY8n1QWfIJaIQA3izA0vvQvBUH44g6N-k9SHpgb36-9WB3EcrfgD-Unef</recordid><startdate>19840715</startdate><enddate>19840715</enddate><creator>Reed, W D</creator><creator>Baab, P J</creator><creator>Hawkins, R L</creator><creator>Ozand, P T</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19840715</creationdate><title>The effects of insulin and glucagon on ketone-body turnover</title><author>Reed, W D ; Baab, P J ; Hawkins, R L ; Ozand, P T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c370t-29132d0a93904026306169e05f6ae14467451dec041948b2062aef56d3b0579b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>3-Hydroxybutyric Acid</topic><topic>Acetoacetates - blood</topic><topic>Animals</topic><topic>Blood Glucose - metabolism</topic><topic>Caprylates - blood</topic><topic>Female</topic><topic>Glucagon - blood</topic><topic>Glucagon - pharmacology</topic><topic>Hydroxybutyrates - blood</topic><topic>Insulin - blood</topic><topic>Insulin - pharmacology</topic><topic>Ketone Bodies - metabolism</topic><topic>Male</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Reed, W D</creatorcontrib><creatorcontrib>Baab, P J</creatorcontrib><creatorcontrib>Hawkins, R L</creatorcontrib><creatorcontrib>Ozand, P T</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Biochemical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Reed, W D</au><au>Baab, P J</au><au>Hawkins, R L</au><au>Ozand, P T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effects of insulin and glucagon on ketone-body turnover</atitle><jtitle>Biochemical journal</jtitle><addtitle>Biochem J</addtitle><date>1984-07-15</date><risdate>1984</risdate><volume>221</volume><issue>2</issue><spage>439</spage><epage>444</epage><pages>439-444</pages><issn>0264-6021</issn><eissn>1470-8728</eissn><abstract>A double-isotope procedure was used to measure the effects of insulin and glucagon on ketone-body production and utilization (i.e. turnover) in the starved rat. Somatostatin was infused during the experiment to suppress the pancreatic release of either hormone. The immediate action of insulin in terms of ketone-body turnover that was most evident was a decreased production of 3-hydroxybutyrate, with no significant change in the turnover of acetoacetate. Similarly, the significant effect of glucagon infusion was to increase the production of 3-hydroxybutyrate, with minimum increase in acetoacetate turnover. The data support a direct effect of both hormones on the distribution of acetyl units derived from fatty acid beta-oxidation.</abstract><cop>England</cop><pmid>6383348</pmid><doi>10.1042/bj2210439</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0264-6021 |
| ispartof | Biochemical journal, 1984-07, Vol.221 (2), p.439-444 |
| issn | 0264-6021 1470-8728 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1144056 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | 3-Hydroxybutyric Acid Acetoacetates - blood Animals Blood Glucose - metabolism Caprylates - blood Female Glucagon - blood Glucagon - pharmacology Hydroxybutyrates - blood Insulin - blood Insulin - pharmacology Ketone Bodies - metabolism Male Rats Rats, Inbred Strains |
| title | The effects of insulin and glucagon on ketone-body turnover |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-24T03%3A41%3A33IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20effects%20of%20insulin%20and%20glucagon%20on%20ketone-body%20turnover&rft.jtitle=Biochemical%20journal&rft.au=Reed,%20W%20D&rft.date=1984-07-15&rft.volume=221&rft.issue=2&rft.spage=439&rft.epage=444&rft.pages=439-444&rft.issn=0264-6021&rft.eissn=1470-8728&rft_id=info:doi/10.1042/bj2210439&rft_dat=%3Cproquest_pubme%3E81241133%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=81241133&rft_id=info:pmid/6383348&rfr_iscdi=true |