Thirdhand Exposures to Tobacco-Specific Nitrosamines through Inhalation, Dust Ingestion, Dermal Uptake, and Epidermal Chemistry

Tobacco-specific nitrosamines (TSNAs) are emitted during smoking and form indoors by nitrosation of nicotine. Two of them, N′-nitrosonornicotine (NNN) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), are human carcinogens with No Significant Risk Levels (NSRLs) of 500 and 14 ng day–1, respe...

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Veröffentlicht in:	Environmental science & technology 2022-09, Vol.56 (17), p.12506-12516
Hauptverfasser:	Tang, Xiaochen, Benowitz, Neal, Gundel, Lara, Hang, Bo, Havel, Christopher M., Hoh, Eunha, Jacob III, Peyton, Mao, Jian-Hua, Martins-Green, Manuela, Matt, Georg E., Quintana, Penelope J. E., Russell, Marion L., Sarker, Altaf, Schick, Suzaynn F., Snijders, Antoine M., Destaillats, Hugo
Format:	Artikel
Sprache:	eng
Schlagworte:	4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone Animals Carcinogens Carcinogens - toxicity Cellulose Cotton Dust Eating Ecotoxicology and Public Health Exposure Genotoxicity Health risks Humans Ingestion Inhalation Metabolites Mice N'-Nitrosonornicotine Nicotine Nicotine - chemistry Nitrosamines Nitrosamines - chemistry Nitrosation Nitrous acid Respiration Risk levels Skin Substrates Tobacco Tobacco Products
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