Ionic mechanisms of action potential prolongation at low temperature in guinea-pig ventricular myocytes

1. We studied the effects of low temperature on the action potentials and membrane currents of guinea-pig ventricular myocytes, using a tight-seal whole-cell clamp technique. 2. The action potential duration at 95% repolarization was prolonged from 146 +/- 33 ms (mean +/- S.D., n = 6) at 33-34 degre...

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Veröffentlicht in:	The Journal of physiology 1993-08, Vol.468 (1), p.85-106
Hauptverfasser:	Kiyosue, T, Arita, M, Muramatsu, H, Spindler, A J, Noble, D
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials Animals Calcium - metabolism Cold Temperature Guinea Pigs Heart - physiology In Vitro Techniques Kinetics Male Membrane Potentials Models, Cardiovascular Myocardium - metabolism Potassium - metabolism Sodium - metabolism Ventricular Function
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