The m6A methyltransferase METTL14 promotes cell proliferation via SETBP1-mediated activation of PI3K-AKT signaling pathway in myelodysplastic neoplasms

N6-methyladenosine (m 6 A) is the most prevalent epitranscriptomic modification in mammalian mRNA. Recent studies have revealed m 6 A is involved in the pathogenesis of various malignant tumors including hematologic neoplasms. Nevertheless, the specific roles of m 6 A modification and m 6 A regulato...

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Veröffentlicht in:	Leukemia 2024-10, Vol.38 (10), p.2246-2258
Hauptverfasser:	Jiang, Lingxu, Zhang, Yudi, Qian, Jiejing, Zhou, Xinping, Ma, Liya, Zhu, Shuanghong, Wang, Lu, Wang, Wei, Yang, Wenli, Luo, Yingwan, Lang, Wei, Xu, Gaixiang, Ren, Yanling, Mei, Chen, Ye, Li, Zhang, Qi, Liu, Xiaozhen, Jin, Jie, Sun, Jie, Tong, Hongyan
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase 38/77 38/90 38/91 59/5 631/67/1990/1673 631/67/395 64/60 692/420/755 82/1 AKT protein Bone marrow Cancer Research Cell activation Cell growth Cell proliferation Critical Care Medicine Health risks Hematology Intensive Internal Medicine Medicine Medicine & Public Health Methyltransferase mRNA N6-methyladenosine Neoplasms Oncology Pathogenesis RNA modification Signal transduction Tumors
Online-Zugang:	Volltext
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