Iron Deficiency and Restless Sleep/Wake Behaviors in Neurodevelopmental Disorders and Mental Health Conditions
Iron deficiency (ID) and restlessness are associated with sleep/wake-disorders (e.g., restless legs syndrome (RLS)) and neurodevelopmental disorders (attention deficit/hyperactivity and autism spectrum disorders (ADHD; ASD)). However, a standardized approach to assessing ID and restlessness is missi...
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| Veröffentlicht in: | Nutrients 2024-09, Vol.16 (18), p.3064 |
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| creator | Ipsiroglu, Osman S Pandher, Parveer K Hill, Olivia McWilliams, Scout Braschel, Melissa Edwards, Katherine Friedlander, Robin Keys, Elizabeth Kuo, Calvin Lewis, Marion Suzanne Richardson, Anamaria Wagner, Alexandra L Wensley, David |
| description | Iron deficiency (ID) and restlessness are associated with sleep/wake-disorders (e.g., restless legs syndrome (RLS)) and neurodevelopmental disorders (attention deficit/hyperactivity and autism spectrum disorders (ADHD; ASD)). However, a standardized approach to assessing ID and restlessness is missing. We reviewed iron status and family sleep/ID history data collected at a sleep/wake behavior clinic under a quality improvement/quality assurance project. Restlessness was explored through patient and parental narratives and a 'suggested clinical immobilization test'. Of 199 patients, 94% had ID, with 43% having a family history of ID. ADHD (46%) and ASD (45%) were common conditions, along with chronic insomnia (61%), sleep-disordered breathing (50%), and parasomnias (22%). In unadjusted analysis, a family history of ID increased the odds (95% CI) of familial RLS (OR: 5.98,
= 0.0002, [2.35-15.2]), insomnia/DIMS (OR: 3.44,
= 0.0084, [1.37-8.64]), and RLS (OR: 7.00,
= 0.01, [1.49-32.93]) in patients with ADHD, and of insomnia/DIMS (OR: 4.77,
= 0.0014, [1.82-12.5]), RLS/PLMS (OR: 5.83,
= 0.009, [1.54-22.1]), RLS (OR: 4.05,
= 0.01, [1.33-12.3]), and familial RLS (OR: 2.82,
= 0.02, [1.17-6.81]) in patients with ASD. ID and restlessness were characteristics of ADHD and ASD, and a family history of ID increased the risk of sleep/wake-disorders. These findings highlight the need to integrate comprehensive blood work and family history to capture ID in children and adolescents with restless behaviors. |
| doi_str_mv | 10.3390/nu16183064 |
| format | Article |
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= 0.0002, [2.35-15.2]), insomnia/DIMS (OR: 3.44,
= 0.0084, [1.37-8.64]), and RLS (OR: 7.00,
= 0.01, [1.49-32.93]) in patients with ADHD, and of insomnia/DIMS (OR: 4.77,
= 0.0014, [1.82-12.5]), RLS/PLMS (OR: 5.83,
= 0.009, [1.54-22.1]), RLS (OR: 4.05,
= 0.01, [1.33-12.3]), and familial RLS (OR: 2.82,
= 0.02, [1.17-6.81]) in patients with ASD. ID and restlessness were characteristics of ADHD and ASD, and a family history of ID increased the risk of sleep/wake-disorders. These findings highlight the need to integrate comprehensive blood work and family history to capture ID in children and adolescents with restless behaviors.</description><identifier>ISSN: 2072-6643</identifier><identifier>EISSN: 2072-6643</identifier><identifier>DOI: 10.3390/nu16183064</identifier><identifier>PMID: 39339663</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Adolescent ; Adults ; Anemia ; Anemia, Iron-Deficiency - epidemiology ; Attention Deficit Disorder with Hyperactivity ; Attention deficit hyperactivity disorder ; Autism ; Autism Spectrum Disorder ; Behavior ; blood ; Brain ; Cardiac patients ; Child ; Child & adolescent psychiatry ; Child, Preschool ; Data collection ; Dopamine ; Families & family life ; family ; Female ; Fetal alcohol syndrome ; Hemoglobin ; Humans ; Iron ; Iron Deficiencies ; Male ; Medical research ; Medicine, Experimental ; Mental disorders ; Mental Health ; Nervous system ; Neurodevelopmental Disorders ; Patients ; Pediatrics ; quality control ; Regression analysis ; Restless legs syndrome ; Restless Legs Syndrome - epidemiology ; risk ; Sleep ; Sleep disorders ; Sleep Initiation and Maintenance Disorders ; Trace elements ; Work-life balance</subject><ispartof>Nutrients, 2024-09, Vol.16 (18), p.3064</ispartof><rights>COPYRIGHT 2024 MDPI AG</rights><rights>2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2024 by the authors. 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c396t-c91cf3f9b6e0f2ae19b0c081dcdec594c480c4b2eb01a5f101f7d40b8a171683</cites><orcidid>0000-0003-1141-2775 ; 0000-0001-7228-4274 ; 0000-0002-6300-5381 ; 0000-0002-0251-0720 ; 0000-0001-8401-9136</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11435348/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11435348/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,725,778,782,883,27911,27912,53778,53780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39339663$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ipsiroglu, Osman S</creatorcontrib><creatorcontrib>Pandher, Parveer K</creatorcontrib><creatorcontrib>Hill, Olivia</creatorcontrib><creatorcontrib>McWilliams, Scout</creatorcontrib><creatorcontrib>Braschel, Melissa</creatorcontrib><creatorcontrib>Edwards, Katherine</creatorcontrib><creatorcontrib>Friedlander, Robin</creatorcontrib><creatorcontrib>Keys, Elizabeth</creatorcontrib><creatorcontrib>Kuo, Calvin</creatorcontrib><creatorcontrib>Lewis, Marion Suzanne</creatorcontrib><creatorcontrib>Richardson, Anamaria</creatorcontrib><creatorcontrib>Wagner, Alexandra L</creatorcontrib><creatorcontrib>Wensley, David</creatorcontrib><title>Iron Deficiency and Restless Sleep/Wake Behaviors in Neurodevelopmental Disorders and Mental Health Conditions</title><title>Nutrients</title><addtitle>Nutrients</addtitle><description>Iron deficiency (ID) and restlessness are associated with sleep/wake-disorders (e.g., restless legs syndrome (RLS)) and neurodevelopmental disorders (attention deficit/hyperactivity and autism spectrum disorders (ADHD; ASD)). However, a standardized approach to assessing ID and restlessness is missing. We reviewed iron status and family sleep/ID history data collected at a sleep/wake behavior clinic under a quality improvement/quality assurance project. Restlessness was explored through patient and parental narratives and a 'suggested clinical immobilization test'. Of 199 patients, 94% had ID, with 43% having a family history of ID. ADHD (46%) and ASD (45%) were common conditions, along with chronic insomnia (61%), sleep-disordered breathing (50%), and parasomnias (22%). In unadjusted analysis, a family history of ID increased the odds (95% CI) of familial RLS (OR: 5.98,
= 0.0002, [2.35-15.2]), insomnia/DIMS (OR: 3.44,
= 0.0084, [1.37-8.64]), and RLS (OR: 7.00,
= 0.01, [1.49-32.93]) in patients with ADHD, and of insomnia/DIMS (OR: 4.77,
= 0.0014, [1.82-12.5]), RLS/PLMS (OR: 5.83,
= 0.009, [1.54-22.1]), RLS (OR: 4.05,
= 0.01, [1.33-12.3]), and familial RLS (OR: 2.82,
= 0.02, [1.17-6.81]) in patients with ASD. ID and restlessness were characteristics of ADHD and ASD, and a family history of ID increased the risk of sleep/wake-disorders. These findings highlight the need to integrate comprehensive blood work and family history to capture ID in children and adolescents with restless behaviors.</description><subject>Adolescent</subject><subject>Adults</subject><subject>Anemia</subject><subject>Anemia, Iron-Deficiency - epidemiology</subject><subject>Attention Deficit Disorder with Hyperactivity</subject><subject>Attention deficit hyperactivity disorder</subject><subject>Autism</subject><subject>Autism Spectrum Disorder</subject><subject>Behavior</subject><subject>blood</subject><subject>Brain</subject><subject>Cardiac patients</subject><subject>Child</subject><subject>Child & adolescent psychiatry</subject><subject>Child, Preschool</subject><subject>Data collection</subject><subject>Dopamine</subject><subject>Families & family life</subject><subject>family</subject><subject>Female</subject><subject>Fetal alcohol syndrome</subject><subject>Hemoglobin</subject><subject>Humans</subject><subject>Iron</subject><subject>Iron Deficiencies</subject><subject>Male</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Mental disorders</subject><subject>Mental Health</subject><subject>Nervous system</subject><subject>Neurodevelopmental Disorders</subject><subject>Patients</subject><subject>Pediatrics</subject><subject>quality control</subject><subject>Regression analysis</subject><subject>Restless legs syndrome</subject><subject>Restless Legs Syndrome - 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epidemiology</topic><topic>Attention Deficit Disorder with Hyperactivity</topic><topic>Attention deficit hyperactivity disorder</topic><topic>Autism</topic><topic>Autism Spectrum Disorder</topic><topic>Behavior</topic><topic>blood</topic><topic>Brain</topic><topic>Cardiac patients</topic><topic>Child</topic><topic>Child & adolescent psychiatry</topic><topic>Child, Preschool</topic><topic>Data collection</topic><topic>Dopamine</topic><topic>Families & family life</topic><topic>family</topic><topic>Female</topic><topic>Fetal alcohol syndrome</topic><topic>Hemoglobin</topic><topic>Humans</topic><topic>Iron</topic><topic>Iron Deficiencies</topic><topic>Male</topic><topic>Medical research</topic><topic>Medicine, Experimental</topic><topic>Mental disorders</topic><topic>Mental Health</topic><topic>Nervous system</topic><topic>Neurodevelopmental Disorders</topic><topic>Patients</topic><topic>Pediatrics</topic><topic>quality control</topic><topic>Regression analysis</topic><topic>Restless legs syndrome</topic><topic>Restless Legs Syndrome - epidemiology</topic><topic>risk</topic><topic>Sleep</topic><topic>Sleep disorders</topic><topic>Sleep Initiation and Maintenance Disorders</topic><topic>Trace elements</topic><topic>Work-life balance</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ipsiroglu, Osman S</creatorcontrib><creatorcontrib>Pandher, Parveer K</creatorcontrib><creatorcontrib>Hill, Olivia</creatorcontrib><creatorcontrib>McWilliams, Scout</creatorcontrib><creatorcontrib>Braschel, Melissa</creatorcontrib><creatorcontrib>Edwards, Katherine</creatorcontrib><creatorcontrib>Friedlander, Robin</creatorcontrib><creatorcontrib>Keys, Elizabeth</creatorcontrib><creatorcontrib>Kuo, Calvin</creatorcontrib><creatorcontrib>Lewis, Marion Suzanne</creatorcontrib><creatorcontrib>Richardson, Anamaria</creatorcontrib><creatorcontrib>Wagner, Alexandra L</creatorcontrib><creatorcontrib>Wensley, David</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nutrients</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ipsiroglu, Osman S</au><au>Pandher, Parveer K</au><au>Hill, Olivia</au><au>McWilliams, Scout</au><au>Braschel, Melissa</au><au>Edwards, Katherine</au><au>Friedlander, Robin</au><au>Keys, Elizabeth</au><au>Kuo, Calvin</au><au>Lewis, Marion Suzanne</au><au>Richardson, Anamaria</au><au>Wagner, Alexandra L</au><au>Wensley, David</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Iron Deficiency and Restless Sleep/Wake Behaviors in Neurodevelopmental Disorders and Mental Health Conditions</atitle><jtitle>Nutrients</jtitle><addtitle>Nutrients</addtitle><date>2024-09-11</date><risdate>2024</risdate><volume>16</volume><issue>18</issue><spage>3064</spage><pages>3064-</pages><issn>2072-6643</issn><eissn>2072-6643</eissn><abstract>Iron deficiency (ID) and restlessness are associated with sleep/wake-disorders (e.g., restless legs syndrome (RLS)) and neurodevelopmental disorders (attention deficit/hyperactivity and autism spectrum disorders (ADHD; ASD)). However, a standardized approach to assessing ID and restlessness is missing. We reviewed iron status and family sleep/ID history data collected at a sleep/wake behavior clinic under a quality improvement/quality assurance project. Restlessness was explored through patient and parental narratives and a 'suggested clinical immobilization test'. Of 199 patients, 94% had ID, with 43% having a family history of ID. ADHD (46%) and ASD (45%) were common conditions, along with chronic insomnia (61%), sleep-disordered breathing (50%), and parasomnias (22%). In unadjusted analysis, a family history of ID increased the odds (95% CI) of familial RLS (OR: 5.98,
= 0.0002, [2.35-15.2]), insomnia/DIMS (OR: 3.44,
= 0.0084, [1.37-8.64]), and RLS (OR: 7.00,
= 0.01, [1.49-32.93]) in patients with ADHD, and of insomnia/DIMS (OR: 4.77,
= 0.0014, [1.82-12.5]), RLS/PLMS (OR: 5.83,
= 0.009, [1.54-22.1]), RLS (OR: 4.05,
= 0.01, [1.33-12.3]), and familial RLS (OR: 2.82,
= 0.02, [1.17-6.81]) in patients with ASD. ID and restlessness were characteristics of ADHD and ASD, and a family history of ID increased the risk of sleep/wake-disorders. These findings highlight the need to integrate comprehensive blood work and family history to capture ID in children and adolescents with restless behaviors.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>39339663</pmid><doi>10.3390/nu16183064</doi><orcidid>https://orcid.org/0000-0003-1141-2775</orcidid><orcidid>https://orcid.org/0000-0001-7228-4274</orcidid><orcidid>https://orcid.org/0000-0002-6300-5381</orcidid><orcidid>https://orcid.org/0000-0002-0251-0720</orcidid><orcidid>https://orcid.org/0000-0001-8401-9136</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; MDPI - Multidisciplinary Digital Publishing Institute; PubMed Central |
| subjects | Adolescent Adults Anemia Anemia, Iron-Deficiency - epidemiology Attention Deficit Disorder with Hyperactivity Attention deficit hyperactivity disorder Autism Autism Spectrum Disorder Behavior blood Brain Cardiac patients Child Child & adolescent psychiatry Child, Preschool Data collection Dopamine Families & family life family Female Fetal alcohol syndrome Hemoglobin Humans Iron Iron Deficiencies Male Medical research Medicine, Experimental Mental disorders Mental Health Nervous system Neurodevelopmental Disorders Patients Pediatrics quality control Regression analysis Restless legs syndrome Restless Legs Syndrome - epidemiology risk Sleep Sleep disorders Sleep Initiation and Maintenance Disorders Trace elements Work-life balance |
| title | Iron Deficiency and Restless Sleep/Wake Behaviors in Neurodevelopmental Disorders and Mental Health Conditions |
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