Predictive Value of the D-Dimer-to-Fibrinogen Ratio for Acute Kidney Injury after Living-Donor Liver Transplantation: A Retrospective Observational Cohort Study Using Logistic Regression and Propensity Score Matching Analyses
Liver transplantation (LT) is typically performed as a surgery to treat end-stage liver disease (ESLD). Factors influencing acute kidney injury (AKI) post-living-donor LT (LDLT) have been identified; however, the potential role of the D-dimer-to-fibrinogen ratio (DFR) in predicting AKI remains unexp...
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| Veröffentlicht in: | Journal of clinical medicine 2024-09, Vol.13 (18), p.5499 |
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| creator | Park, Jaesik Kim, Minju Kim, Jong-Woan Choi, Ho Joong Hong, Sang Hyun |
| description | Liver transplantation (LT) is typically performed as a surgery to treat end-stage liver disease (ESLD). Factors influencing acute kidney injury (AKI) post-living-donor LT (LDLT) have been identified; however, the potential role of the D-dimer-to-fibrinogen ratio (DFR) in predicting AKI remains unexplored. Therefore, we analyzed the relationship between DFR levels and the occurrence of AKI following LT.
We retrospectively analyzed 648 recipients after 76 were excluded based on the exclusion criteria. Multivariate logistic regression and propensity score (PS) matching analyses were performed to evaluate the association between a high DFR (>1.05) and AKI.
After LDLT, AKI was observed in 148 patients (22.8%). A high DFR (>1.05) was independently associated with AKI. Multivariate logistic regression analysis showed that patients with a DFR above this threshold were four times more susceptible to AKI than those with a low DFR. A high DFR was also significantly associated with AKI in the propensity score-matched patients.
Our findings suggest that incorporating preoperative DFR assessment into the management of patients undergoing LDLT could enhance the risk stratification for postoperative AKI. |
| doi_str_mv | 10.3390/jcm13185499 |
| format | Article |
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We retrospectively analyzed 648 recipients after 76 were excluded based on the exclusion criteria. Multivariate logistic regression and propensity score (PS) matching analyses were performed to evaluate the association between a high DFR (>1.05) and AKI.
After LDLT, AKI was observed in 148 patients (22.8%). A high DFR (>1.05) was independently associated with AKI. Multivariate logistic regression analysis showed that patients with a DFR above this threshold were four times more susceptible to AKI than those with a low DFR. A high DFR was also significantly associated with AKI in the propensity score-matched patients.
Our findings suggest that incorporating preoperative DFR assessment into the management of patients undergoing LDLT could enhance the risk stratification for postoperative AKI.</description><identifier>ISSN: 2077-0383</identifier><identifier>EISSN: 2077-0383</identifier><identifier>DOI: 10.3390/jcm13185499</identifier><identifier>PMID: 39336986</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Acute renal failure ; Age ; Ascites ; Blood platelets ; Blood pressure ; Body mass index ; Creatinine ; Ejection fraction ; Fibrinogen ; Health aspects ; Hemodynamics ; Hepatitis ; Hypertension ; Ischemia ; Kidney diseases ; Laboratories ; Liver ; Liver cirrhosis ; Liver diseases ; Liver transplants ; Physiological aspects ; Postoperative period ; Potassium ; Regression analysis ; Risk factors ; Transplantation ; Urine</subject><ispartof>Journal of clinical medicine, 2024-09, Vol.13 (18), p.5499</ispartof><rights>COPYRIGHT 2024 MDPI AG</rights><rights>2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2024 by the authors. 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c365t-21c0e37b7924bcebc3e57108c8b6bd5f2f8db993c8a73f2a25cf5151afb193903</cites><orcidid>0000-0002-0862-098X ; 0000-0001-5472-9567 ; 0000-0002-7091-8963</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11432109/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11432109/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39336986$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Park, Jaesik</creatorcontrib><creatorcontrib>Kim, Minju</creatorcontrib><creatorcontrib>Kim, Jong-Woan</creatorcontrib><creatorcontrib>Choi, Ho Joong</creatorcontrib><creatorcontrib>Hong, Sang Hyun</creatorcontrib><title>Predictive Value of the D-Dimer-to-Fibrinogen Ratio for Acute Kidney Injury after Living-Donor Liver Transplantation: A Retrospective Observational Cohort Study Using Logistic Regression and Propensity Score Matching Analyses</title><title>Journal of clinical medicine</title><addtitle>J Clin Med</addtitle><description>Liver transplantation (LT) is typically performed as a surgery to treat end-stage liver disease (ESLD). Factors influencing acute kidney injury (AKI) post-living-donor LT (LDLT) have been identified; however, the potential role of the D-dimer-to-fibrinogen ratio (DFR) in predicting AKI remains unexplored. Therefore, we analyzed the relationship between DFR levels and the occurrence of AKI following LT.
We retrospectively analyzed 648 recipients after 76 were excluded based on the exclusion criteria. Multivariate logistic regression and propensity score (PS) matching analyses were performed to evaluate the association between a high DFR (>1.05) and AKI.
After LDLT, AKI was observed in 148 patients (22.8%). A high DFR (>1.05) was independently associated with AKI. Multivariate logistic regression analysis showed that patients with a DFR above this threshold were four times more susceptible to AKI than those with a low DFR. A high DFR was also significantly associated with AKI in the propensity score-matched patients.
Our findings suggest that incorporating preoperative DFR assessment into the management of patients undergoing LDLT could enhance the risk stratification for postoperative AKI.</description><subject>Acute renal failure</subject><subject>Age</subject><subject>Ascites</subject><subject>Blood platelets</subject><subject>Blood pressure</subject><subject>Body mass index</subject><subject>Creatinine</subject><subject>Ejection fraction</subject><subject>Fibrinogen</subject><subject>Health aspects</subject><subject>Hemodynamics</subject><subject>Hepatitis</subject><subject>Hypertension</subject><subject>Ischemia</subject><subject>Kidney diseases</subject><subject>Laboratories</subject><subject>Liver</subject><subject>Liver cirrhosis</subject><subject>Liver diseases</subject><subject>Liver transplants</subject><subject>Physiological aspects</subject><subject>Postoperative period</subject><subject>Potassium</subject><subject>Regression analysis</subject><subject>Risk factors</subject><subject>Transplantation</subject><subject>Urine</subject><issn>2077-0383</issn><issn>2077-0383</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNptkl1vFCEUhidGY5vaK-8NiTcmZuowzAd4Yza7VhvXtOmHt4RhDrNsZmAFZpP5uf4T2W6tWyNcAIfnfU_gnCR5jbMzQlj2YS0HTDAtC8aeJcd5VtdpRih5frA_Sk69X2dxUFrkuH6ZHBFGSMVodZz8unLQahn0FtAP0Y-ArEJhBWiRLvQALg02PdeN08Z2YNC1CNoiZR2ayTEA-qZbAxO6MOvRTUioAA4t9VabLl1YY-8PMXTrhPGbXpiw05uPaIauITjrN7BPfdl4cNv7S9GjuV1ZF9BNGNsJ3fnohpa20z5oGXWdA-8jiIRp0ZWzGzBehwndSOsAfRdBrnaKWXSaPPhXyQsleg-nD-tJcnf--Xb-NV1efrmYz5apJFUZ0hzLDEjd1CwvGgmNJFDWOKOSNlXTlipXtG0YI5KKmqhc5KVUJS6xUA1msRLkJPm0992MzQCtBBOc6PnG6UG4iVuh-dMbo1e8s1uOcUFynLHo8O7BwdmfI_jAB-0l9PHfwI6eExwpjDHboW__Qdd2dPHFe6rEFOf5X6oTPXBtlI2J5c6Uz2hMW2S0rCJ19h8qzhYGLa0BpWP8ieD9XiBjBb0D9fhInPFdV_KDroz0m8N_eWT_9CD5DWRy4Tw</recordid><startdate>20240917</startdate><enddate>20240917</enddate><creator>Park, Jaesik</creator><creator>Kim, Minju</creator><creator>Kim, Jong-Woan</creator><creator>Choi, Ho Joong</creator><creator>Hong, Sang Hyun</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>COVID</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-0862-098X</orcidid><orcidid>https://orcid.org/0000-0001-5472-9567</orcidid><orcidid>https://orcid.org/0000-0002-7091-8963</orcidid></search><sort><creationdate>20240917</creationdate><title>Predictive Value of the D-Dimer-to-Fibrinogen Ratio for Acute Kidney Injury after Living-Donor Liver Transplantation: A Retrospective Observational Cohort Study Using Logistic Regression and Propensity Score Matching Analyses</title><author>Park, Jaesik ; Kim, Minju ; Kim, Jong-Woan ; Choi, Ho Joong ; Hong, Sang Hyun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c365t-21c0e37b7924bcebc3e57108c8b6bd5f2f8db993c8a73f2a25cf5151afb193903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Acute renal failure</topic><topic>Age</topic><topic>Ascites</topic><topic>Blood platelets</topic><topic>Blood pressure</topic><topic>Body mass index</topic><topic>Creatinine</topic><topic>Ejection fraction</topic><topic>Fibrinogen</topic><topic>Health aspects</topic><topic>Hemodynamics</topic><topic>Hepatitis</topic><topic>Hypertension</topic><topic>Ischemia</topic><topic>Kidney diseases</topic><topic>Laboratories</topic><topic>Liver</topic><topic>Liver cirrhosis</topic><topic>Liver diseases</topic><topic>Liver transplants</topic><topic>Physiological aspects</topic><topic>Postoperative period</topic><topic>Potassium</topic><topic>Regression analysis</topic><topic>Risk factors</topic><topic>Transplantation</topic><topic>Urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Park, Jaesik</creatorcontrib><creatorcontrib>Kim, Minju</creatorcontrib><creatorcontrib>Kim, Jong-Woan</creatorcontrib><creatorcontrib>Choi, Ho Joong</creatorcontrib><creatorcontrib>Hong, Sang Hyun</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Coronavirus Research Database</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of clinical medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Park, Jaesik</au><au>Kim, Minju</au><au>Kim, Jong-Woan</au><au>Choi, Ho Joong</au><au>Hong, Sang Hyun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Predictive Value of the D-Dimer-to-Fibrinogen Ratio for Acute Kidney Injury after Living-Donor Liver Transplantation: A Retrospective Observational Cohort Study Using Logistic Regression and Propensity Score Matching Analyses</atitle><jtitle>Journal of clinical medicine</jtitle><addtitle>J Clin Med</addtitle><date>2024-09-17</date><risdate>2024</risdate><volume>13</volume><issue>18</issue><spage>5499</spage><pages>5499-</pages><issn>2077-0383</issn><eissn>2077-0383</eissn><abstract>Liver transplantation (LT) is typically performed as a surgery to treat end-stage liver disease (ESLD). Factors influencing acute kidney injury (AKI) post-living-donor LT (LDLT) have been identified; however, the potential role of the D-dimer-to-fibrinogen ratio (DFR) in predicting AKI remains unexplored. Therefore, we analyzed the relationship between DFR levels and the occurrence of AKI following LT.
We retrospectively analyzed 648 recipients after 76 were excluded based on the exclusion criteria. Multivariate logistic regression and propensity score (PS) matching analyses were performed to evaluate the association between a high DFR (>1.05) and AKI.
After LDLT, AKI was observed in 148 patients (22.8%). A high DFR (>1.05) was independently associated with AKI. Multivariate logistic regression analysis showed that patients with a DFR above this threshold were four times more susceptible to AKI than those with a low DFR. A high DFR was also significantly associated with AKI in the propensity score-matched patients.
Our findings suggest that incorporating preoperative DFR assessment into the management of patients undergoing LDLT could enhance the risk stratification for postoperative AKI.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>39336986</pmid><doi>10.3390/jcm13185499</doi><orcidid>https://orcid.org/0000-0002-0862-098X</orcidid><orcidid>https://orcid.org/0000-0001-5472-9567</orcidid><orcidid>https://orcid.org/0000-0002-7091-8963</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Acute renal failure Age Ascites Blood platelets Blood pressure Body mass index Creatinine Ejection fraction Fibrinogen Health aspects Hemodynamics Hepatitis Hypertension Ischemia Kidney diseases Laboratories Liver Liver cirrhosis Liver diseases Liver transplants Physiological aspects Postoperative period Potassium Regression analysis Risk factors Transplantation Urine |
| title | Predictive Value of the D-Dimer-to-Fibrinogen Ratio for Acute Kidney Injury after Living-Donor Liver Transplantation: A Retrospective Observational Cohort Study Using Logistic Regression and Propensity Score Matching Analyses |
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