Fine-Scale Haplotype Mapping Reveals an Association of the FTO Gene with Osteoporosis and Fracture Risk in Postmenopausal Women

The Fat Mass and Obesity-Associated ( ) gene encodes a demethylase, which modulates RNA N6-methyladenosine (m6A) and plays a regulatory role in adipocyte differentiation and the pathogenesis of human obesity. To understand the potential role of in osteoporosis (OP), we investigated five single nucle...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Genes 2024-09, Vol.15 (9), p.1152
Hauptverfasser:	Greere, Daniela, Haydar, Sara, Grigorescu, Florin, Manda, Dana, Voicu, Gabriela, Lautier, Corinne, Poiana, Catalina
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Alleles Alpha-Ketoglutarate-Dependent Dioxygenase FTO - genetics Blood pressure Body fat Body mass index Bone Density - genetics Bone marrow Bone mineral density Bone turnover Communication Epigenetic inheritance Epigenetics Female Fractures Fractures, Bone - genetics Fto gene Gene mapping Genes Genetic aspects Genetic Predisposition to Disease Genotyping Haplotypes Humans Insulin resistance Low Density Lipoprotein Receptor-Related Protein-5 - genetics LRP5 protein Metabolism Middle Aged N6-methyladenosine Obesity Older people Osteoporosis Osteoporosis, Postmenopausal - genetics Osteoporotic Fractures - genetics Phenotypes Physiological aspects Polymorphism, Single Nucleotide Population genetics Post-menopause Postmenopausal women Postmenopause - genetics Regression analysis Risk factors Type 2 diabetes White people Womens health
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!