A reappraisal of the value of carcinoembryonic antigen in the management of patients with various neoplasms
Eight hundred and eight patients with histologically proved malignant disease had carcinoembryonic antigen (CEA) estimations performed at the time of tissue diagnosis. An elevated level was found in 384 of 518 patients with gastrointestinal neoplasms (74 per cent) and in 162 of 290 patients with oth...
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| Veröffentlicht in: | British journal of surgery 1979-02, Vol.66 (2), p.120-123 |
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| container_title | British journal of surgery |
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| creator | Cooper, M. J. Mackie, C. R. Skinner, D. B. Moossa, A. R. |
| description | Eight hundred and eight patients with histologically proved malignant disease had carcinoembryonic antigen (CEA) estimations performed at the time of tissue diagnosis. An elevated level was found in 384 of 518 patients with gastrointestinal neoplasms (74 per cent) and in 162 of 290 patients with other neoplasms (56 per cent). No correlation was found between CEA elevations and tumour differentiation. There was a good correlation between tumour staging and CEA levels for patients with colorectal cancer; the more advanced the tumour, the higher the CEA.
Several illustrative cases are presented and the role of CEA assay in the diagnosis and management of neoplasia is discussed. CEA assay is a poor screening test for neoplastic disease, but serial CEA monitoring is valuable in the detection of residual or recurrent cancer. |
| doi_str_mv | 10.1002/bjs.1800660212 |
| format | Article |
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Several illustrative cases are presented and the role of CEA assay in the diagnosis and management of neoplasia is discussed. CEA assay is a poor screening test for neoplastic disease, but serial CEA monitoring is valuable in the detection of residual or recurrent cancer.</description><identifier>ISSN: 0007-1323</identifier><identifier>EISSN: 1365-2168</identifier><identifier>DOI: 10.1002/bjs.1800660212</identifier><identifier>PMID: 420982</identifier><language>eng</language><publisher>Bristol: John Wiley & Sons, Ltd</publisher><subject>Adult ; Aged ; Carcinoembryonic Antigen - analysis ; Colonic Neoplasms - immunology ; Colonic Neoplasms - pathology ; Female ; Gastrointestinal Neoplasms - immunology ; Humans ; Male ; Neoplasm Metastasis ; Neoplasm Staging ; Neoplasms - diagnosis ; Neoplasms - immunology ; Neoplasms - pathology ; Prognosis ; Rectal Neoplasms - immunology ; Rectal Neoplasms - pathology</subject><ispartof>British journal of surgery, 1979-02, Vol.66 (2), p.120-123</ispartof><rights>Copyright © 1979 British Journal of Surgery Society Ltd.</rights><rights>Copyright © 1979 British Journal of Surgery Society Ltd. 1979</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3942-f867314c14f22de297cf0a65730b6061741b4f69469dc4ac008ac5b3a50a8d983</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fbjs.1800660212$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fbjs.1800660212$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/420982$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cooper, M. J.</creatorcontrib><creatorcontrib>Mackie, C. R.</creatorcontrib><creatorcontrib>Skinner, D. B.</creatorcontrib><creatorcontrib>Moossa, A. R.</creatorcontrib><title>A reappraisal of the value of carcinoembryonic antigen in the management of patients with various neoplasms</title><title>British journal of surgery</title><addtitle>Br J Surg</addtitle><description>Eight hundred and eight patients with histologically proved malignant disease had carcinoembryonic antigen (CEA) estimations performed at the time of tissue diagnosis. An elevated level was found in 384 of 518 patients with gastrointestinal neoplasms (74 per cent) and in 162 of 290 patients with other neoplasms (56 per cent). No correlation was found between CEA elevations and tumour differentiation. There was a good correlation between tumour staging and CEA levels for patients with colorectal cancer; the more advanced the tumour, the higher the CEA.
Several illustrative cases are presented and the role of CEA assay in the diagnosis and management of neoplasia is discussed. CEA assay is a poor screening test for neoplastic disease, but serial CEA monitoring is valuable in the detection of residual or recurrent cancer.</description><subject>Adult</subject><subject>Aged</subject><subject>Carcinoembryonic Antigen - analysis</subject><subject>Colonic Neoplasms - immunology</subject><subject>Colonic Neoplasms - pathology</subject><subject>Female</subject><subject>Gastrointestinal Neoplasms - immunology</subject><subject>Humans</subject><subject>Male</subject><subject>Neoplasm Metastasis</subject><subject>Neoplasm Staging</subject><subject>Neoplasms - diagnosis</subject><subject>Neoplasms - immunology</subject><subject>Neoplasms - pathology</subject><subject>Prognosis</subject><subject>Rectal Neoplasms - immunology</subject><subject>Rectal Neoplasms - pathology</subject><issn>0007-1323</issn><issn>1365-2168</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1979</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVUUtv1DAQthCvpXDlxCEnbinjR2znhEoF26LykAqCmzXxOrtuEyfYScv-e7xstYXTzOh7jD0fIS8pHFMA9qa5SsdUA0gJjLIHZEG5rEpGpX5IFgCgSsoZf0qepXQFQDlU7Al5LBjUmi3I9UkRHY5jRJ-wK4a2mDauuMFudrvBYrQ-DK5v4nYI3hYYJr92ofDhL7HHgGvXuzDt2CNOPrepuPXTJptEP8ypCG4YO0x9ek4etdgl9-KuHpHvH95_Oz0rL74sz09PLkrLa8HKVkvFqbBUtIytHKuVbQFlpTg0EiRVgjailbWQ9coKtAAabdVwrAD1qtb8iLzd-45z07uVzU-K2Jkx-h7j1gzozf9I8BuzHm4MpYIpzSA7vL5ziMOv2aXJ9D5Z13WYPzMno4SogFKWia_-XXXYsT9vhus9fOs7tz2gFMwuOpOjM_fRmXcfL--nrC33Wp8m9_ugxXht8n1UZX58Xpqf6vIrVXppPvE_LbOeKg</recordid><startdate>197902</startdate><enddate>197902</enddate><creator>Cooper, M. J.</creator><creator>Mackie, C. R.</creator><creator>Skinner, D. B.</creator><creator>Moossa, A. R.</creator><general>John Wiley & Sons, Ltd</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>197902</creationdate><title>A reappraisal of the value of carcinoembryonic antigen in the management of patients with various neoplasms</title><author>Cooper, M. J. ; Mackie, C. R. ; Skinner, D. B. ; Moossa, A. R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3942-f867314c14f22de297cf0a65730b6061741b4f69469dc4ac008ac5b3a50a8d983</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1979</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Carcinoembryonic Antigen - analysis</topic><topic>Colonic Neoplasms - immunology</topic><topic>Colonic Neoplasms - pathology</topic><topic>Female</topic><topic>Gastrointestinal Neoplasms - immunology</topic><topic>Humans</topic><topic>Male</topic><topic>Neoplasm Metastasis</topic><topic>Neoplasm Staging</topic><topic>Neoplasms - diagnosis</topic><topic>Neoplasms - immunology</topic><topic>Neoplasms - pathology</topic><topic>Prognosis</topic><topic>Rectal Neoplasms - immunology</topic><topic>Rectal Neoplasms - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cooper, M. J.</creatorcontrib><creatorcontrib>Mackie, C. R.</creatorcontrib><creatorcontrib>Skinner, D. B.</creatorcontrib><creatorcontrib>Moossa, A. R.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cooper, M. J.</au><au>Mackie, C. R.</au><au>Skinner, D. B.</au><au>Moossa, A. R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A reappraisal of the value of carcinoembryonic antigen in the management of patients with various neoplasms</atitle><jtitle>British journal of surgery</jtitle><addtitle>Br J Surg</addtitle><date>1979-02</date><risdate>1979</risdate><volume>66</volume><issue>2</issue><spage>120</spage><epage>123</epage><pages>120-123</pages><issn>0007-1323</issn><eissn>1365-2168</eissn><abstract>Eight hundred and eight patients with histologically proved malignant disease had carcinoembryonic antigen (CEA) estimations performed at the time of tissue diagnosis. An elevated level was found in 384 of 518 patients with gastrointestinal neoplasms (74 per cent) and in 162 of 290 patients with other neoplasms (56 per cent). No correlation was found between CEA elevations and tumour differentiation. There was a good correlation between tumour staging and CEA levels for patients with colorectal cancer; the more advanced the tumour, the higher the CEA.
Several illustrative cases are presented and the role of CEA assay in the diagnosis and management of neoplasia is discussed. CEA assay is a poor screening test for neoplastic disease, but serial CEA monitoring is valuable in the detection of residual or recurrent cancer.</abstract><cop>Bristol</cop><pub>John Wiley & Sons, Ltd</pub><pmid>420982</pmid><doi>10.1002/bjs.1800660212</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0007-1323 |
| ispartof | British journal of surgery, 1979-02, Vol.66 (2), p.120-123 |
| issn | 0007-1323 1365-2168 |
| language | eng |
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| source | MEDLINE; Wiley Journals |
| subjects | Adult Aged Carcinoembryonic Antigen - analysis Colonic Neoplasms - immunology Colonic Neoplasms - pathology Female Gastrointestinal Neoplasms - immunology Humans Male Neoplasm Metastasis Neoplasm Staging Neoplasms - diagnosis Neoplasms - immunology Neoplasms - pathology Prognosis Rectal Neoplasms - immunology Rectal Neoplasms - pathology |
| title | A reappraisal of the value of carcinoembryonic antigen in the management of patients with various neoplasms |
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