Ostarine blunts the effect of endurance training on submaximal endurance in rats
The purpose of this study is to study the effects of ostarine alone and in combination with endurance training in sexually mature, male Wistar rats. The rats were divided into a treadmill-trained group and a sedentary group. Half of each group received either ostarine or vehicle for 8 weeks ( n = 1...
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| creator | Vasilev, Veselin Boyadjiev, Nikolay Hrischev, Petar Gerginska, Fanka Delchev, Slavi Arabadzhiyska, Desislava Komrakova, Marina Boeker, Kai O. Schilling, Arndt F. Georgieva, Katerina |
| description | The purpose of this study is to study the effects of ostarine alone and in combination with endurance training in sexually mature, male Wistar rats. The rats were divided into a treadmill-trained group and a sedentary group. Half of each group received either ostarine or vehicle for 8 weeks (
n
= 10 each, in total
n
= 40). We examined some functional, hormonal, and anthropometric parameters and the myogenic gene expression of myostatin, insulin-like growth factor-1 (IGF-1), and vascular endothelial growth factor-A (VEGF-A) in m. gastrocnemius. Ostarine decreased submaximal endurance and increased myogenic gene expression of myostatin but had no effect on maximal time to exhaustion and grip strength. Training increased submaximal endurance, maximal time to exhaustion, and grip strength. Our results indicate that both exercise and ostarine treatment had no significant effects on serum levels of luteinizing hormone, follicle-stimulating hormone, and testosterone, or on the myogenic gene expression of IGF-1 and VEGF-A. Neither ostarine nor the training had a significant effect on the testis, liver, and heart weights. In conclusion, ostarine had no effect on anthropometric and hormonal parameters but increased the myostatin gene expression in muscle. The SARM treatment decreased submaximal endurance without affecting maximal time to exhaustion, and training increased both metrics. |
| doi_str_mv | 10.1007/s00210-024-03030-w |
| format | Article |
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n
= 10 each, in total
n
= 40). We examined some functional, hormonal, and anthropometric parameters and the myogenic gene expression of myostatin, insulin-like growth factor-1 (IGF-1), and vascular endothelial growth factor-A (VEGF-A) in m. gastrocnemius. Ostarine decreased submaximal endurance and increased myogenic gene expression of myostatin but had no effect on maximal time to exhaustion and grip strength. Training increased submaximal endurance, maximal time to exhaustion, and grip strength. Our results indicate that both exercise and ostarine treatment had no significant effects on serum levels of luteinizing hormone, follicle-stimulating hormone, and testosterone, or on the myogenic gene expression of IGF-1 and VEGF-A. Neither ostarine nor the training had a significant effect on the testis, liver, and heart weights. In conclusion, ostarine had no effect on anthropometric and hormonal parameters but increased the myostatin gene expression in muscle. The SARM treatment decreased submaximal endurance without affecting maximal time to exhaustion, and training increased both metrics.</description><identifier>ISSN: 0028-1298</identifier><identifier>ISSN: 1432-1912</identifier><identifier>EISSN: 1432-1912</identifier><identifier>DOI: 10.1007/s00210-024-03030-w</identifier><identifier>PMID: 38451281</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Animals ; Biomedical and Life Sciences ; Biomedicine ; Endurance Training ; Follicle-stimulating hormone ; Gene expression ; Insulin-like growth factor I ; Insulin-Like Growth Factor I - genetics ; Insulin-Like Growth Factor I - metabolism ; Insulin-like growth factors ; Luteinizing hormone ; Male ; Muscle, Skeletal - drug effects ; Muscle, Skeletal - metabolism ; Muscle, Skeletal - physiology ; Myostatin ; Myostatin - genetics ; Myostatin - metabolism ; Neurosciences ; Pharmacology/Toxicology ; Physical Conditioning, Animal - physiology ; Physical Endurance - drug effects ; Rats ; Rats, Wistar ; Resins, Plant - pharmacology ; Serum levels ; Testosterone ; Testosterone - blood ; Vascular endothelial growth factor ; Vascular Endothelial Growth Factor A - genetics ; Vascular Endothelial Growth Factor A - metabolism</subject><ispartof>Naunyn-Schmiedeberg's archives of pharmacology, 2024-09, Vol.397 (9), p.6523-6532</ispartof><rights>The Author(s) 2024</rights><rights>2024. The Author(s).</rights><rights>The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s) 2024 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c426t-63ee49d488bbdd416eb3f371bf74cd10f9887f48a8bd984520206914e4e655453</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00210-024-03030-w$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00210-024-03030-w$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,315,781,785,886,27929,27930,41493,42562,51324</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38451281$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vasilev, Veselin</creatorcontrib><creatorcontrib>Boyadjiev, Nikolay</creatorcontrib><creatorcontrib>Hrischev, Petar</creatorcontrib><creatorcontrib>Gerginska, Fanka</creatorcontrib><creatorcontrib>Delchev, Slavi</creatorcontrib><creatorcontrib>Arabadzhiyska, Desislava</creatorcontrib><creatorcontrib>Komrakova, Marina</creatorcontrib><creatorcontrib>Boeker, Kai O.</creatorcontrib><creatorcontrib>Schilling, Arndt F.</creatorcontrib><creatorcontrib>Georgieva, Katerina</creatorcontrib><title>Ostarine blunts the effect of endurance training on submaximal endurance in rats</title><title>Naunyn-Schmiedeberg's archives of pharmacology</title><addtitle>Naunyn-Schmiedeberg's Arch Pharmacol</addtitle><addtitle>Naunyn Schmiedebergs Arch Pharmacol</addtitle><description>The purpose of this study is to study the effects of ostarine alone and in combination with endurance training in sexually mature, male Wistar rats. The rats were divided into a treadmill-trained group and a sedentary group. Half of each group received either ostarine or vehicle for 8 weeks (
n
= 10 each, in total
n
= 40). We examined some functional, hormonal, and anthropometric parameters and the myogenic gene expression of myostatin, insulin-like growth factor-1 (IGF-1), and vascular endothelial growth factor-A (VEGF-A) in m. gastrocnemius. Ostarine decreased submaximal endurance and increased myogenic gene expression of myostatin but had no effect on maximal time to exhaustion and grip strength. Training increased submaximal endurance, maximal time to exhaustion, and grip strength. Our results indicate that both exercise and ostarine treatment had no significant effects on serum levels of luteinizing hormone, follicle-stimulating hormone, and testosterone, or on the myogenic gene expression of IGF-1 and VEGF-A. Neither ostarine nor the training had a significant effect on the testis, liver, and heart weights. In conclusion, ostarine had no effect on anthropometric and hormonal parameters but increased the myostatin gene expression in muscle. The SARM treatment decreased submaximal endurance without affecting maximal time to exhaustion, and training increased both metrics.</description><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Endurance Training</subject><subject>Follicle-stimulating hormone</subject><subject>Gene expression</subject><subject>Insulin-like growth factor I</subject><subject>Insulin-Like Growth Factor I - genetics</subject><subject>Insulin-Like Growth Factor I - metabolism</subject><subject>Insulin-like growth factors</subject><subject>Luteinizing hormone</subject><subject>Male</subject><subject>Muscle, Skeletal - drug effects</subject><subject>Muscle, Skeletal - metabolism</subject><subject>Muscle, Skeletal - physiology</subject><subject>Myostatin</subject><subject>Myostatin - genetics</subject><subject>Myostatin - metabolism</subject><subject>Neurosciences</subject><subject>Pharmacology/Toxicology</subject><subject>Physical Conditioning, Animal - physiology</subject><subject>Physical Endurance - drug effects</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Resins, Plant - pharmacology</subject><subject>Serum levels</subject><subject>Testosterone</subject><subject>Testosterone - blood</subject><subject>Vascular endothelial growth factor</subject><subject>Vascular Endothelial Growth Factor A - genetics</subject><subject>Vascular Endothelial Growth Factor A - metabolism</subject><issn>0028-1298</issn><issn>1432-1912</issn><issn>1432-1912</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><recordid>eNp9kUtP3TAQhS0EglvaP9BFZYlNNykzthM7qwpd0YeEBAtYW04yvgTlOtROePz7ml6gwAJ54cX55swZHcY-I3xDAH2YAARCAUIVIPMrbrfYApUUBdYottki66ZAUZs99iGlKwCosCx32Z40qkRhcMHOTtPkYh-IN8McpsSnS-LkPbUTHz2n0M3RhZb4FF0f-rDiY-Bpbtburl-74QXQBx7dlD6yHe-GRJ8e_3128eP4fPmrODn9-Xt5dFK0SlRTUUkiVXfKmKbpOoUVNdJLjY3Xqu0QfG2M9so403R1TitAQFWjIkVVWapS7rPvG9_rHIa6lkJOONjrmGPFezu63r5WQn9pV-ONRVRCKC2zw9dHhzj-mSlNdt2nlobBBRrnZEWtBBot9MOygzfo1TjHkO-zEsGYUoNWmRIbqo1jSpH8cxoE-9CY3TRmc2P2X2P2Ng99eXnH88hTRRmQGyBlKawo_t_9ju1f8P6h0Q</recordid><startdate>20240901</startdate><enddate>20240901</enddate><creator>Vasilev, Veselin</creator><creator>Boyadjiev, Nikolay</creator><creator>Hrischev, Petar</creator><creator>Gerginska, Fanka</creator><creator>Delchev, Slavi</creator><creator>Arabadzhiyska, Desislava</creator><creator>Komrakova, Marina</creator><creator>Boeker, Kai O.</creator><creator>Schilling, Arndt F.</creator><creator>Georgieva, Katerina</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20240901</creationdate><title>Ostarine blunts the effect of endurance training on submaximal endurance in rats</title><author>Vasilev, Veselin ; Boyadjiev, Nikolay ; Hrischev, Petar ; Gerginska, Fanka ; Delchev, Slavi ; Arabadzhiyska, Desislava ; Komrakova, Marina ; Boeker, Kai O. ; Schilling, Arndt F. ; Georgieva, Katerina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c426t-63ee49d488bbdd416eb3f371bf74cd10f9887f48a8bd984520206914e4e655453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Animals</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Endurance Training</topic><topic>Follicle-stimulating hormone</topic><topic>Gene expression</topic><topic>Insulin-like growth factor I</topic><topic>Insulin-Like Growth Factor I - genetics</topic><topic>Insulin-Like Growth Factor I - metabolism</topic><topic>Insulin-like growth factors</topic><topic>Luteinizing hormone</topic><topic>Male</topic><topic>Muscle, Skeletal - drug effects</topic><topic>Muscle, Skeletal - metabolism</topic><topic>Muscle, Skeletal - physiology</topic><topic>Myostatin</topic><topic>Myostatin - genetics</topic><topic>Myostatin - metabolism</topic><topic>Neurosciences</topic><topic>Pharmacology/Toxicology</topic><topic>Physical Conditioning, Animal - physiology</topic><topic>Physical Endurance - drug effects</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Resins, Plant - pharmacology</topic><topic>Serum levels</topic><topic>Testosterone</topic><topic>Testosterone - blood</topic><topic>Vascular endothelial growth factor</topic><topic>Vascular Endothelial Growth Factor A - genetics</topic><topic>Vascular Endothelial Growth Factor A - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vasilev, Veselin</creatorcontrib><creatorcontrib>Boyadjiev, Nikolay</creatorcontrib><creatorcontrib>Hrischev, Petar</creatorcontrib><creatorcontrib>Gerginska, Fanka</creatorcontrib><creatorcontrib>Delchev, Slavi</creatorcontrib><creatorcontrib>Arabadzhiyska, Desislava</creatorcontrib><creatorcontrib>Komrakova, Marina</creatorcontrib><creatorcontrib>Boeker, Kai O.</creatorcontrib><creatorcontrib>Schilling, Arndt F.</creatorcontrib><creatorcontrib>Georgieva, Katerina</creatorcontrib><collection>Springer Nature OA/Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Naunyn-Schmiedeberg's archives of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vasilev, Veselin</au><au>Boyadjiev, Nikolay</au><au>Hrischev, Petar</au><au>Gerginska, Fanka</au><au>Delchev, Slavi</au><au>Arabadzhiyska, Desislava</au><au>Komrakova, Marina</au><au>Boeker, Kai O.</au><au>Schilling, Arndt F.</au><au>Georgieva, Katerina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ostarine blunts the effect of endurance training on submaximal endurance in rats</atitle><jtitle>Naunyn-Schmiedeberg's archives of pharmacology</jtitle><stitle>Naunyn-Schmiedeberg's Arch Pharmacol</stitle><addtitle>Naunyn Schmiedebergs Arch Pharmacol</addtitle><date>2024-09-01</date><risdate>2024</risdate><volume>397</volume><issue>9</issue><spage>6523</spage><epage>6532</epage><pages>6523-6532</pages><issn>0028-1298</issn><issn>1432-1912</issn><eissn>1432-1912</eissn><abstract>The purpose of this study is to study the effects of ostarine alone and in combination with endurance training in sexually mature, male Wistar rats. The rats were divided into a treadmill-trained group and a sedentary group. Half of each group received either ostarine or vehicle for 8 weeks (
n
= 10 each, in total
n
= 40). We examined some functional, hormonal, and anthropometric parameters and the myogenic gene expression of myostatin, insulin-like growth factor-1 (IGF-1), and vascular endothelial growth factor-A (VEGF-A) in m. gastrocnemius. Ostarine decreased submaximal endurance and increased myogenic gene expression of myostatin but had no effect on maximal time to exhaustion and grip strength. Training increased submaximal endurance, maximal time to exhaustion, and grip strength. Our results indicate that both exercise and ostarine treatment had no significant effects on serum levels of luteinizing hormone, follicle-stimulating hormone, and testosterone, or on the myogenic gene expression of IGF-1 and VEGF-A. Neither ostarine nor the training had a significant effect on the testis, liver, and heart weights. In conclusion, ostarine had no effect on anthropometric and hormonal parameters but increased the myostatin gene expression in muscle. The SARM treatment decreased submaximal endurance without affecting maximal time to exhaustion, and training increased both metrics.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>38451281</pmid><doi>10.1007/s00210-024-03030-w</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Animals Biomedical and Life Sciences Biomedicine Endurance Training Follicle-stimulating hormone Gene expression Insulin-like growth factor I Insulin-Like Growth Factor I - genetics Insulin-Like Growth Factor I - metabolism Insulin-like growth factors Luteinizing hormone Male Muscle, Skeletal - drug effects Muscle, Skeletal - metabolism Muscle, Skeletal - physiology Myostatin Myostatin - genetics Myostatin - metabolism Neurosciences Pharmacology/Toxicology Physical Conditioning, Animal - physiology Physical Endurance - drug effects Rats Rats, Wistar Resins, Plant - pharmacology Serum levels Testosterone Testosterone - blood Vascular endothelial growth factor Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor A - metabolism |
| title | Ostarine blunts the effect of endurance training on submaximal endurance in rats |
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