28-day repeated dose response study of diglycolic acid: Renal and hepatic effects

The acute oral toxicity of diglycolic acid (DGA) was evaluated. Groups of female rats (n = 8 rats/group) received 28 consecutive daily single doses of 0.3, 1.0, 3.0, 10.0, 30.0, 100.0 or 300.0 mg DGA/kg body weight by gastric intubation. One group of animals served as vehicle control. Tissues and bl...

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Veröffentlicht in:	Food and chemical toxicology 2017-08, Vol.106 (Pt A), p.558-567
Hauptverfasser:	Sprando, Robert L., Mossoba, Miriam E., Black, Thomas, Keltner, Zachary, Vohra, Sanah, Olejnik, Nicholas, Toomer, Howard, Stine, Cynthia, Evans, Eric, Sprando, Jessica L., Ferguson, Martine
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Structures - drug effects Animal Structures - pathology Animals Diglycolic acid Dose-Response Relationship, Drug Female Glycolates - administration & dosage Glycolates - toxicity Hepatic toxicity Kidney - drug effects Kidney - pathology Liver - drug effects Liver - pathology Oral exposure Rats Rats, Sprague-Dawley Renal toxicity Toxicity Tests
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