A unifying mechanism for seipin‐mediated lipid droplet formation

Lipid droplets (LDs) are dynamic organelles essential for cellular lipid homeostasis. Assembly of LDs occurs in the endoplasmic reticulum (ER), and the conserved ER membrane protein seipin emerged as a key player in this process. Here, we review recent advances provided by structural, biochemical, a...

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Veröffentlicht in:	FEBS letters 2024-05, Vol.598 (10), p.1116-1126
Hauptverfasser:	Klug, Yoel A., Ferreira, Joana V., Carvalho, Pedro
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals biogenesis computer simulation droplets endoplasmic reticulum Endoplasmic Reticulum - metabolism GTP-Binding Protein gamma Subunits - chemistry GTP-Binding Protein gamma Subunits - genetics GTP-Binding Protein gamma Subunits - metabolism homeostasis Humans lipid droplet Lipid Droplets - metabolism Lipid Metabolism Lipids membrane proteins neutral lipids pathogenesis Review Reviews seipin triglyceride
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