Harnessing biocatalysis as a green tool in antibiotic synthesis and discovery
Biocatalysis offers a sustainable approach to drug synthesis, leveraging the high selectivity and efficiency of enzymes. This review explores the application of biocatalysis in the early-stage synthesis of antimicrobial compounds, emphasizing its advantages over traditional chemical methods. We disc...
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| Veröffentlicht in: | RSC advances 2024-09, Vol.14 (41), p.3396-341 |
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| creator | Fernandes, Guilherme F. S Kim, Seong-Heun Castagnolo, Daniele |
| description | Biocatalysis offers a sustainable approach to drug synthesis, leveraging the high selectivity and efficiency of enzymes. This review explores the application of biocatalysis in the early-stage synthesis of antimicrobial compounds, emphasizing its advantages over traditional chemical methods. We discuss various biocatalysts, including enzymes and whole-cell systems, and their role in the selective functionalization and preparation of antimicrobials and antibacterial building blocks. The review underscores the potential of biocatalysis to advance the development of new antibiotics and suggests directions and potential applications of enzymes in drug development.
Biocatalysis offers a sustainable approach to drug synthesis, leveraging the high selectivity and efficiency of enzymes. |
| doi_str_mv | 10.1039/d4ra04824e |
| format | Article |
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Biocatalysis offers a sustainable approach to drug synthesis, leveraging the high selectivity and efficiency of enzymes.</description><subject>Antibiotics</subject><subject>Antiinfectives and antibacterials</subject><subject>Chemical compounds</subject><subject>Chemical synthesis</subject><subject>Chemistry</subject><subject>Enzymes</subject><issn>2046-2069</issn><issn>2046-2069</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNpd0UtLAzEQB_Agiop68a4seBGhOtm8NicpvkERpPeQzaZtZJtoshX67U0f1moIJDA_Jhn-CB1juMRA5FVDowZaldRuof0SKO-VwOX2xn0PHaX0DnlxhkuOd9EekQRXlIl99PKoo7cpOT8qaheM7nQ7Sy4VOu9iFK31RRdCWzhfaN-5bDpnijTz3dgunG-KxiUTvmycHaKdoW6TPVqdB2hwfze4eew9vz483fSfeya_2_VKTVltOUjMJei6EboGxpgUEhsqBK-xBmEkI7hugA1rw62uDBDAVFrZkAN0vWz7Ma0ntjHWd1G36iO6iY4zFbRTfyvejdUofCmMaQlCVLnD-apDDJ9Tmzo1yTPYttXehmlSBIOkBCrOMj37R9_DNPo83lxlUUnBs7pYKhNDStEO17_BoOZBqVv61l8EdZfx6eb_1_QnlgxOliAms67-Jk2-ASUCl-Y</recordid><startdate>20240918</startdate><enddate>20240918</enddate><creator>Fernandes, Guilherme F. S</creator><creator>Kim, Seong-Heun</creator><creator>Castagnolo, Daniele</creator><general>Royal Society of Chemistry</general><general>The Royal Society of Chemistry</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-7644-5466</orcidid><orcidid>https://orcid.org/0000-0002-7517-5732</orcidid></search><sort><creationdate>20240918</creationdate><title>Harnessing biocatalysis as a green tool in antibiotic synthesis and discovery</title><author>Fernandes, Guilherme F. S ; Kim, Seong-Heun ; Castagnolo, Daniele</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c318t-2a45be6091690abd7ab05559791c4776b1a07c9531bd05fbc6ea8c030149e9d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Antibiotics</topic><topic>Antiinfectives and antibacterials</topic><topic>Chemical compounds</topic><topic>Chemical synthesis</topic><topic>Chemistry</topic><topic>Enzymes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fernandes, Guilherme F. S</creatorcontrib><creatorcontrib>Kim, Seong-Heun</creatorcontrib><creatorcontrib>Castagnolo, Daniele</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>RSC advances</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fernandes, Guilherme F. S</au><au>Kim, Seong-Heun</au><au>Castagnolo, Daniele</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Harnessing biocatalysis as a green tool in antibiotic synthesis and discovery</atitle><jtitle>RSC advances</jtitle><addtitle>RSC Adv</addtitle><date>2024-09-18</date><risdate>2024</risdate><volume>14</volume><issue>41</issue><spage>3396</spage><epage>341</epage><pages>3396-341</pages><issn>2046-2069</issn><eissn>2046-2069</eissn><abstract>Biocatalysis offers a sustainable approach to drug synthesis, leveraging the high selectivity and efficiency of enzymes. This review explores the application of biocatalysis in the early-stage synthesis of antimicrobial compounds, emphasizing its advantages over traditional chemical methods. We discuss various biocatalysts, including enzymes and whole-cell systems, and their role in the selective functionalization and preparation of antimicrobials and antibacterial building blocks. The review underscores the potential of biocatalysis to advance the development of new antibiotics and suggests directions and potential applications of enzymes in drug development.
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| source | DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; PubMed Central Open Access |
| subjects | Antibiotics Antiinfectives and antibacterials Chemical compounds Chemical synthesis Chemistry Enzymes |
| title | Harnessing biocatalysis as a green tool in antibiotic synthesis and discovery |
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