Evaluation of the Importance of Capsule Transparency in Dry Powder Inhalation Devices
The aim of this work is to test whether the use of a transparent capsule affects the residual capsule weight after inhalation as a surrogate of the inhaled delivered dose for patients with non-reversible chronic airway disease. Researchers conducted an observational cross-sectional study with patien...
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| Veröffentlicht in: | Annals of family medicine 2024-09, Vol.22 (5), p.417-420 |
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| container_title | Annals of family medicine |
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| creator | Arija, Rocío Reinoso de la Espada, Rosario Ruiz-Serrano Ollero, Mª Dolores Núñez Hernandez, Laura Carrasco Gallego, Esther Quintana López-Campos, Jose Luis |
| description | The aim of this work is to test whether the use of a transparent capsule affects the residual capsule weight after inhalation as a surrogate of the inhaled delivered dose for patients with non-reversible chronic airway disease. Researchers conducted an observational cross-sectional study with patients using a single-dose dry powder inhaler. The weight of the capsule was measured with a precision microbalance before and after inhalation. Ninety-one patients were included, of whom 63 (69.2%) used a transparent capsule. Inhalation with a transparent capsule achieved a weight decrease of 30.1% vs 8.6% for devices with an opaque capsule ( |
| doi_str_mv | 10.1370/afm.3147 |
| format | Article |
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<0.001). These data reinforce the need to provide patients with mechanisms that verify the correct inhalation technique.</description><identifier>ISSN: 1544-1709</identifier><identifier>ISSN: 1544-1717</identifier><identifier>EISSN: 1544-1717</identifier><identifier>DOI: 10.1370/afm.3147</identifier><identifier>PMID: 39313335</identifier><language>eng</language><publisher>United States: Annals of Family Medicine</publisher><subject>Administration, Inhalation ; Adult ; Aged ; Capsules ; Capsules (Pharmacy) ; Cross-Sectional Studies ; Design and construction ; Dry Powder Inhalers ; Equipment Design ; Evaluation ; Female ; Humans ; Inhalers ; Male ; Medical research ; Medicine, Experimental ; Middle Aged ; Pharmaceutical research ; Research Briefs ; Tiotropium</subject><ispartof>Annals of family medicine, 2024-09, Vol.22 (5), p.417-420</ispartof><rights>2024 Annals of Family Medicine, Inc.</rights><rights>COPYRIGHT 2024 Annals of Family Medicine</rights><rights>2024 Annals of Family Medicine, Inc. 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11419709/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11419709/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39313335$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Arija, Rocío Reinoso</creatorcontrib><creatorcontrib>de la Espada, Rosario Ruiz-Serrano</creatorcontrib><creatorcontrib>Ollero, Mª Dolores Núñez</creatorcontrib><creatorcontrib>Hernandez, Laura Carrasco</creatorcontrib><creatorcontrib>Gallego, Esther Quintana</creatorcontrib><creatorcontrib>López-Campos, Jose Luis</creatorcontrib><title>Evaluation of the Importance of Capsule Transparency in Dry Powder Inhalation Devices</title><title>Annals of family medicine</title><addtitle>Ann Fam Med</addtitle><description>The aim of this work is to test whether the use of a transparent capsule affects the residual capsule weight after inhalation as a surrogate of the inhaled delivered dose for patients with non-reversible chronic airway disease. Researchers conducted an observational cross-sectional study with patients using a single-dose dry powder inhaler. The weight of the capsule was measured with a precision microbalance before and after inhalation. Ninety-one patients were included, of whom 63 (69.2%) used a transparent capsule. Inhalation with a transparent capsule achieved a weight decrease of 30.1% vs 8.6% for devices with an opaque capsule (
<0.001). These data reinforce the need to provide patients with mechanisms that verify the correct inhalation technique.</description><subject>Administration, Inhalation</subject><subject>Adult</subject><subject>Aged</subject><subject>Capsules</subject><subject>Capsules (Pharmacy)</subject><subject>Cross-Sectional Studies</subject><subject>Design and construction</subject><subject>Dry Powder Inhalers</subject><subject>Equipment Design</subject><subject>Evaluation</subject><subject>Female</subject><subject>Humans</subject><subject>Inhalers</subject><subject>Male</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Middle Aged</subject><subject>Pharmaceutical research</subject><subject>Research Briefs</subject><subject>Tiotropium</subject><issn>1544-1709</issn><issn>1544-1717</issn><issn>1544-1717</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkkGL2zAQhU1p6W63hf6CYiiUXpxqJDuKT2XJbtvAQnvYPQtZGscqsuRKdkr-fWWShg0EHSRG37xhHi_L3gNZAOPki2z7BYOSv8iuoSrLAjjwl6c3qa-yNzH-JoQCZfR1dsVqBoyx6jp7ut9JO8nReJf7Nh87zDf94MMoncK5spZDnCzmj0G6OMiATu1z4_K7sM9_-b8aQ75xnbQHiTvcGYXxbfaqlTbiu-N9kz19u39c_ygefn7frG8fClUSMhaSk0YqXPFKKaD1siaoS11r2qBC2tBSa1RVWXFaLWkFRAJysmpbViOjjW7YTfb1oDtMTY9aoRuDtGIIppdhL7w04vzHmU5s_U4AlFAnY5LC56NC8H8mjKPoTVRorXTopygYkBVPwxlJ6McDupUWhXGtT5JqxsXtChipljUsE1VcoLboMM33DluTymf84gKfjsbeqIsNn541dCjt2EVvp9n_eA4eV1PBxxiwPfkCRMyxESk2Yo5NQj889_EE_s8J-wc_cbwm</recordid><startdate>20240901</startdate><enddate>20240901</enddate><creator>Arija, Rocío Reinoso</creator><creator>de la Espada, Rosario Ruiz-Serrano</creator><creator>Ollero, Mª Dolores Núñez</creator><creator>Hernandez, Laura Carrasco</creator><creator>Gallego, Esther Quintana</creator><creator>López-Campos, Jose Luis</creator><general>Annals of Family Medicine</general><general>American Academy of Family Physicians</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20240901</creationdate><title>Evaluation of the Importance of Capsule Transparency in Dry Powder Inhalation Devices</title><author>Arija, Rocío Reinoso ; 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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Administration, Inhalation Adult Aged Capsules Capsules (Pharmacy) Cross-Sectional Studies Design and construction Dry Powder Inhalers Equipment Design Evaluation Female Humans Inhalers Male Medical research Medicine, Experimental Middle Aged Pharmaceutical research Research Briefs Tiotropium |
| title | Evaluation of the Importance of Capsule Transparency in Dry Powder Inhalation Devices |
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