Effects of Life-Long Exercise on Age-Related Inflammation, Apoptosis, Oxidative Stress, Ferroptosis Markers, and NRF2/KAEP 1/Klotho Pathway in Rat Kidneys

Xi-Kun Yuan Pin-Shi Ni Zhen-Hao Yan Zhi Yu Zhuang-Zhi Wang Chen-Kai Zhang Fang-Hui Li Xiao-Ming Yu 1Sports Department, Nanjing University of Science and Technology ZiJin College, Nanjing, China, 2School of Sport Sciences, Nanjing Normal University, Nanjing, China, 3Shanghai Seventh People's Hos...

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Veröffentlicht in:	Physiological research 2024-08, Vol.73 (4), p.577-591
Hauptverfasser:	Yuan, Xi-Kun, Ni, Pin-Shi, Yan, Zhen-Hao, Yu, Zhi, Wang, Zhuang-Zhi, Zhang, Chen-Kai, Li, Fang-Hui, Yu, Xiao-Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Aging - metabolism Aging - pathology Animals Apoptosis Apoptosis - physiology Autophagy Biomarkers - metabolism Cardiomyocytes Chronic illnesses Cyclin-dependent kinase inhibitor p21 Cytokines Ethanol Exercise Experiments Female Ferroptosis Ferroptosis - physiology Fluorescence Glomerulus Glucuronidase - metabolism GTP-binding protein IL-1β Immunofluorescence Inflammation Inflammation - metabolism Inflammation - pathology Interleukin 6 Kidney - metabolism Kidney - pathology Kidney diseases Kidneys Klotho protein Klotho Proteins Laboratory animals Medical research Metabolism NF-E2-Related Factor 2 - metabolism NRF2 protein Oxidative stress Oxidative Stress - physiology p53 Protein Physical Conditioning, Animal - physiology Physical fitness Protein expression Proteins Rats Rats, Sprague-Dawley Renal tubules Senescence Senescence-associated protein Signal Transduction - physiology Tumor necrosis factor-α Western blotting
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