Exploration of compounds to inhibit the Panton-Valentine leukocidin of Staphylococcus aureus

The Panton-Valentine leukocidin (PVL) of Staphylococcus aureus is associated with necrotizing infections. After binding to complement 5a receptor (C5aR/CD88) and CD45 it causes cytolysis in polymorphonuclear neutrophils (PMNs) as well as inflammasome activation in monocytes. The objective of this st...

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Veröffentlicht in:	Medical microbiology and immunology 2024-12, Vol.213 (1), p.19, Article 19
Hauptverfasser:	Grebe, Tobias, Sarkari, Mithra Tatjana, Cherkaoui, Angelika, Schaumburg, Frieder
Format:	Artikel
Sprache:	eng
Schlagworte:	Agonists Anti-Bacterial Agents - pharmacology Bacterial Toxins - metabolism Biomedical and Life Sciences Biomedicine CD45 antigen Cell activation Cytolysis Cytotoxicity Exotoxins - antagonists & inhibitors Exotoxins - metabolism Exotoxins - pharmacology Flow cytometry Humans IL-1β Immunology Inflammasomes Inflammasomes - metabolism Interleukin-1beta - metabolism Leukocidin Leukocidins - antagonists & inhibitors Leukocidins - metabolism Leukocyte Common Antigens - metabolism Leukocytes (neutrophilic) Leukocytes (polymorphonuclear) Medical Microbiology Monocytes Monocytes - drug effects Monocytes - immunology Monocytes - metabolism Neutrophils - drug effects Neutrophils - immunology Neutrophils - metabolism Receptor, Anaphylatoxin C5a - antagonists & inhibitors Receptor, Anaphylatoxin C5a - metabolism Staphylococcal Infections - drug therapy Staphylococcal Infections - microbiology Staphylococcus aureus Staphylococcus aureus - drug effects Virology
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