Evolutionary dynamics in gut-colonizing Candida glabrata during caspofungin therapy: Emergence of clinically important mutations in sphingolipid biosynthesis

Invasive fungal infections are associated with high mortality, which is exacerbated by the limited antifungal drug armamentarium and increasing antifungal drug resistance. Echinocandins are a frontline antifungal drug class targeting β-glucan synthase (GS), a fungal cell wall biosynthetic enzyme. Ec...

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Veröffentlicht in:	PLoS pathogens 2024-09, Vol.20 (9), p.e1012521
Hauptverfasser:	Hassoun, Yasmine, Aptekmann, Ariel A, Keniya, Mikhail V, Gomez, Rosa Y, Alayo, Nicole, Novi, Giovanna, Quinteros, Christopher, Kaya, Firat, Zimmerman, Matthew, Caceres, Diego H, Chow, Nancy A, Perlin, David S, Shor, Erika
Format:	Artikel
Sprache:	eng
Schlagworte:	Biology and Life Sciences Biosynthesis Candida Caspofungin Dosage and administration Gene mutations Genetic aspects Medicine and Health Sciences Microbiological research Physiological aspects Sphingolipids
Online-Zugang:	Volltext
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