TRPM3, TRPM4, and TRPM5 as thermo-sensitive channels
Temperature detection is essential for the survival and perpetuation of any species. Thermoreceptors in the skin sense body temperature as well as the temperatures of ambient air and objects. Since Dr. David Julius and his colleagues discovered that TRPV1 is expressed in small-diameter primary senso...
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| Veröffentlicht in: | The journal of physiological sciences 2024-09, Vol.74 (1), p.43, Article 43 |
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| description | Temperature detection is essential for the survival and perpetuation of any species. Thermoreceptors in the skin sense body temperature as well as the temperatures of ambient air and objects. Since Dr. David Julius and his colleagues discovered that TRPV1 is expressed in small-diameter primary sensory neurons, and activated by temperatures above 42 °C, 11 of thermo-sensitive TRP channels have been identified. TRPM3 expressed in sensory neurons acts as a sensor for noxious heat. TRPM4 and TRPM5 are Ca
⁺-activated monovalent cation channels, and their activity is drastically potentiated by temperature increase. This review aims to summarize the expression patterns, electrophysiological properties, and physiological roles of TRPM3, TRPM4, and TRPM5 associated with thermosensation. |
| doi_str_mv | 10.1186/s12576-024-00937-0 |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; SpringerLink Journals; Springer Nature OA Free Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Animals Humans Neurons Physiological aspects Primidone Review Sensory Receptor Cells - metabolism Sensory Receptor Cells - physiology Skin Thermoreceptors - metabolism Thermoreceptors - physiology Thermosensing - physiology TRPM Cation Channels - metabolism |
| title | TRPM3, TRPM4, and TRPM5 as thermo-sensitive channels |
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