Effect of sex-specific abdominal fat tissue composition on WHO/ISUP nuclear grade of clear cell renal cell carcinoma

To investigate the relationship between sex-related visceral obesity and WHO/ISUP nuclear grade in clear cell renal cell carcinoma (ccRCC). Between January 2018 and June 2022, 95 patients (56 men and 39 women) with pathologically proven ccRCC who underwent abdominal computed tomography examination w...

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Veröffentlicht in:	Turkish journal of medical sciences 2024-01, Vol.54 (4), p.784-791
Hauptverfasser:	Bulut, Eser, Küpeli, Ali, Ramazanoğlu, Mehmet Akif, Aydin, Hasan Rıza, Sibal, İbrahim, Biçaklioğlu, Fatih, Yildirim, Fatih, Adanur, Şenol, Al, Salih
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Schlagworte:	Abdominal Fat - diagnostic imaging Abdominal Fat - pathology Adult Aged Body Mass Index Carcinoma, Renal Cell - diagnostic imaging Carcinoma, Renal Cell - pathology Female Humans Intra-Abdominal Fat - diagnostic imaging Intra-Abdominal Fat - pathology Kidney Neoplasms - diagnostic imaging Kidney Neoplasms - pathology Male Middle Aged Neoplasm Grading Retrospective Studies Sex Factors Tomography, X-Ray Computed
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container_title	Turkish journal of medical sciences
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creator	Bulut, Eser Küpeli, Ali Ramazanoğlu, Mehmet Akif Aydin, Hasan Rıza Sibal, İbrahim Biçaklioğlu, Fatih Yildirim, Fatih Adanur, Şenol Al, Salih
description	To investigate the relationship between sex-related visceral obesity and WHO/ISUP nuclear grade in clear cell renal cell carcinoma (ccRCC). Between January 2018 and June 2022, 95 patients (56 men and 39 women) with pathologically proven ccRCC who underwent abdominal computed tomography examination were retrospectively examined. The patients were classified into two groups: low- and high-WHO/ISUP nuclear grade ccRCC (n = 58 and n = 37), respectively. Patient height, weight, body mass index (BMI), sex, age, subcutaneous fat area (SFA), visceral fat area (VFA), total fat area (TFA), and percentage of visceral fat (VF%) were recorded for the two groups. No significant differences were found in age, BMI, SFA, or TFA, but VFA and VF% were significantly higher in the high-grade patient group. In males, maximal tumor diameter (MTD) (67.8% sensitivity and 76.9% specificity) had the highest area under the curve (AUC), while in females, VF% (70.0% sensitivity and 73.7% specificity) had the highest AUC. VF% revealed an odds ratio (OR) of 1.09 in females with high-grade ccRCC, and in males, MTD was an independent predictor of ccRCC with an OR of 1.03. Sex-related body fat tissue, including VFA and VF%, could be used for estimating WHO/ISUP nuclear grade in patients with ccRCC, especially in females.
doi_str_mv	10.55730/1300-0144.5850
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Between January 2018 and June 2022, 95 patients (56 men and 39 women) with pathologically proven ccRCC who underwent abdominal computed tomography examination were retrospectively examined. The patients were classified into two groups: low- and high-WHO/ISUP nuclear grade ccRCC (n = 58 and n = 37), respectively. Patient height, weight, body mass index (BMI), sex, age, subcutaneous fat area (SFA), visceral fat area (VFA), total fat area (TFA), and percentage of visceral fat (VF%) were recorded for the two groups. No significant differences were found in age, BMI, SFA, or TFA, but VFA and VF% were significantly higher in the high-grade patient group. In males, maximal tumor diameter (MTD) (67.8% sensitivity and 76.9% specificity) had the highest area under the curve (AUC), while in females, VF% (70.0% sensitivity and 73.7% specificity) had the highest AUC. VF% revealed an odds ratio (OR) of 1.09 in females with high-grade ccRCC, and in males, MTD was an independent predictor of ccRCC with an OR of 1.03. Sex-related body fat tissue, including VFA and VF%, could be used for estimating WHO/ISUP nuclear grade in patients with ccRCC, especially in females.</description><identifier>ISSN: 1300-0144</identifier><identifier>EISSN: 1303-6165</identifier><identifier>EISSN: 1300-0144</identifier><identifier>DOI: 10.55730/1300-0144.5850</identifier><identifier>PMID: 39295621</identifier><language>eng</language><publisher>Turkey: Scientific and Technological Research Council of Turkey (TUBITAK)</publisher><subject>Abdominal Fat - diagnostic imaging ; Abdominal Fat - pathology ; Adult ; Aged ; Body Mass Index ; Carcinoma, Renal Cell - diagnostic imaging ; Carcinoma, Renal Cell - pathology ; Female ; Humans ; Intra-Abdominal Fat - diagnostic imaging ; Intra-Abdominal Fat - pathology ; Kidney Neoplasms - diagnostic imaging ; Kidney Neoplasms - pathology ; Male ; Middle Aged ; Neoplasm Grading ; Retrospective Studies ; Sex Factors ; Tomography, X-Ray Computed</subject><ispartof>Turkish journal of medical sciences, 2024-01, Vol.54 (4), p.784-791</ispartof><rights>TÜBİTAK.</rights><rights>TÜBİTAK 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0002-7544-9430 ; 0000-0002-6765-6552 ; 0000-0001-6999-5745 ; 0000-0002-5322-2972 ; 0000-0002-6272-6929 ; 0000-0001-7175-713X ; 0000-0001-6033-7500 ; 0000-0002-7637-133X ; 0000-0003-0859-1741</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11407362/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11407362/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,886,27929,27930,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39295621$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bulut, Eser</creatorcontrib><creatorcontrib>Küpeli, Ali</creatorcontrib><creatorcontrib>Ramazanoğlu, Mehmet Akif</creatorcontrib><creatorcontrib>Aydin, Hasan Rıza</creatorcontrib><creatorcontrib>Sibal, İbrahim</creatorcontrib><creatorcontrib>Biçaklioğlu, Fatih</creatorcontrib><creatorcontrib>Yildirim, Fatih</creatorcontrib><creatorcontrib>Adanur, Şenol</creatorcontrib><creatorcontrib>Al, Salih</creatorcontrib><title>Effect of sex-specific abdominal fat tissue composition on WHO/ISUP nuclear grade of clear cell renal cell carcinoma</title><title>Turkish journal of medical sciences</title><addtitle>Turk J Med Sci</addtitle><description>To investigate the relationship between sex-related visceral obesity and WHO/ISUP nuclear grade in clear cell renal cell carcinoma (ccRCC). Between January 2018 and June 2022, 95 patients (56 men and 39 women) with pathologically proven ccRCC who underwent abdominal computed tomography examination were retrospectively examined. The patients were classified into two groups: low- and high-WHO/ISUP nuclear grade ccRCC (n = 58 and n = 37), respectively. Patient height, weight, body mass index (BMI), sex, age, subcutaneous fat area (SFA), visceral fat area (VFA), total fat area (TFA), and percentage of visceral fat (VF%) were recorded for the two groups. No significant differences were found in age, BMI, SFA, or TFA, but VFA and VF% were significantly higher in the high-grade patient group. In males, maximal tumor diameter (MTD) (67.8% sensitivity and 76.9% specificity) had the highest area under the curve (AUC), while in females, VF% (70.0% sensitivity and 73.7% specificity) had the highest AUC. VF% revealed an odds ratio (OR) of 1.09 in females with high-grade ccRCC, and in males, MTD was an independent predictor of ccRCC with an OR of 1.03. Sex-related body fat tissue, including VFA and VF%, could be used for estimating WHO/ISUP nuclear grade in patients with ccRCC, especially in females.</description><subject>Abdominal Fat - diagnostic imaging</subject><subject>Abdominal Fat - pathology</subject><subject>Adult</subject><subject>Aged</subject><subject>Body Mass Index</subject><subject>Carcinoma, Renal Cell - diagnostic imaging</subject><subject>Carcinoma, Renal Cell - pathology</subject><subject>Female</subject><subject>Humans</subject><subject>Intra-Abdominal Fat - diagnostic imaging</subject><subject>Intra-Abdominal Fat - pathology</subject><subject>Kidney Neoplasms - diagnostic imaging</subject><subject>Kidney Neoplasms - pathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasm Grading</subject><subject>Retrospective Studies</subject><subject>Sex Factors</subject><subject>Tomography, X-Ray Computed</subject><issn>1300-0144</issn><issn>1303-6165</issn><issn>1300-0144</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkVFLwzAQx4Mobk6ffZN8gW5J07TNk8iYbiBMcOJjSNPLjLTNSDrRb2-76lAI5J-73C-X_yF0TcmU84yRGWWERIQmyZTnnJygcRdgUUpTfnrQQ3KELkJ4JyRmCRfnaMRELHga0zFqF8aAbrEzOMBnFHagrbEaq6J0tW1UhY1qcWtD2APWrt65YFvrGtyt1-V6tnp-ecLNXlegPN56VUKPGo4aqgp76CEHqZXXtnG1ukRnRlUBrn72CdrcLzbzZfS4fljN7x4jHWd5G-UFKSA2XSslL0kOGnKd5DGUtFNU0YKCEkwJIsruW0QbJrQgRZ6alCqdsQm6HbC7fVFDqaFpvarkztta-S_plJX_M419k1v3ISlNSMbSuCPMBoL2LgQP5lhMiTwMQPYey95j2Q-gq7j5--bx_q_j7BsGdoOd</recordid><startdate>20240101</startdate><enddate>20240101</enddate><creator>Bulut, Eser</creator><creator>Küpeli, Ali</creator><creator>Ramazanoğlu, Mehmet Akif</creator><creator>Aydin, Hasan Rıza</creator><creator>Sibal, İbrahim</creator><creator>Biçaklioğlu, Fatih</creator><creator>Yildirim, Fatih</creator><creator>Adanur, Şenol</creator><creator>Al, Salih</creator><general>Scientific and Technological Research Council of Turkey (TUBITAK)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-7544-9430</orcidid><orcidid>https://orcid.org/0000-0002-6765-6552</orcidid><orcidid>https://orcid.org/0000-0001-6999-5745</orcidid><orcidid>https://orcid.org/0000-0002-5322-2972</orcidid><orcidid>https://orcid.org/0000-0002-6272-6929</orcidid><orcidid>https://orcid.org/0000-0001-7175-713X</orcidid><orcidid>https://orcid.org/0000-0001-6033-7500</orcidid><orcidid>https://orcid.org/0000-0002-7637-133X</orcidid><orcidid>https://orcid.org/0000-0003-0859-1741</orcidid></search><sort><creationdate>20240101</creationdate><title>Effect of sex-specific abdominal fat tissue composition on WHO/ISUP nuclear grade of clear cell renal cell carcinoma</title><author>Bulut, Eser ; Küpeli, Ali ; Ramazanoğlu, Mehmet Akif ; Aydin, Hasan Rıza ; Sibal, İbrahim ; Biçaklioğlu, Fatih ; Yildirim, Fatih ; Adanur, Şenol ; Al, Salih</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c278t-8b0be2fabdd5d08ece8c482ed1ce81a1b1ea93a909d4590cf39c90b86f61ac73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Abdominal Fat - diagnostic imaging</topic><topic>Abdominal Fat - pathology</topic><topic>Adult</topic><topic>Aged</topic><topic>Body Mass Index</topic><topic>Carcinoma, Renal Cell - diagnostic imaging</topic><topic>Carcinoma, Renal Cell - pathology</topic><topic>Female</topic><topic>Humans</topic><topic>Intra-Abdominal Fat - diagnostic imaging</topic><topic>Intra-Abdominal Fat - pathology</topic><topic>Kidney Neoplasms - diagnostic imaging</topic><topic>Kidney Neoplasms - pathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasm Grading</topic><topic>Retrospective Studies</topic><topic>Sex Factors</topic><topic>Tomography, X-Ray Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bulut, Eser</creatorcontrib><creatorcontrib>Küpeli, Ali</creatorcontrib><creatorcontrib>Ramazanoğlu, Mehmet Akif</creatorcontrib><creatorcontrib>Aydin, Hasan Rıza</creatorcontrib><creatorcontrib>Sibal, İbrahim</creatorcontrib><creatorcontrib>Biçaklioğlu, Fatih</creatorcontrib><creatorcontrib>Yildirim, Fatih</creatorcontrib><creatorcontrib>Adanur, Şenol</creatorcontrib><creatorcontrib>Al, Salih</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Turkish journal of medical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bulut, Eser</au><au>Küpeli, Ali</au><au>Ramazanoğlu, Mehmet Akif</au><au>Aydin, Hasan Rıza</au><au>Sibal, İbrahim</au><au>Biçaklioğlu, Fatih</au><au>Yildirim, Fatih</au><au>Adanur, Şenol</au><au>Al, Salih</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of sex-specific abdominal fat tissue composition on WHO/ISUP nuclear grade of clear cell renal cell carcinoma</atitle><jtitle>Turkish journal of medical sciences</jtitle><addtitle>Turk J Med Sci</addtitle><date>2024-01-01</date><risdate>2024</risdate><volume>54</volume><issue>4</issue><spage>784</spage><epage>791</epage><pages>784-791</pages><issn>1300-0144</issn><eissn>1303-6165</eissn><eissn>1300-0144</eissn><abstract>To investigate the relationship between sex-related visceral obesity and WHO/ISUP nuclear grade in clear cell renal cell carcinoma (ccRCC). Between January 2018 and June 2022, 95 patients (56 men and 39 women) with pathologically proven ccRCC who underwent abdominal computed tomography examination were retrospectively examined. The patients were classified into two groups: low- and high-WHO/ISUP nuclear grade ccRCC (n = 58 and n = 37), respectively. Patient height, weight, body mass index (BMI), sex, age, subcutaneous fat area (SFA), visceral fat area (VFA), total fat area (TFA), and percentage of visceral fat (VF%) were recorded for the two groups. No significant differences were found in age, BMI, SFA, or TFA, but VFA and VF% were significantly higher in the high-grade patient group. In males, maximal tumor diameter (MTD) (67.8% sensitivity and 76.9% specificity) had the highest area under the curve (AUC), while in females, VF% (70.0% sensitivity and 73.7% specificity) had the highest AUC. VF% revealed an odds ratio (OR) of 1.09 in females with high-grade ccRCC, and in males, MTD was an independent predictor of ccRCC with an OR of 1.03. Sex-related body fat tissue, including VFA and VF%, could be used for estimating WHO/ISUP nuclear grade in patients with ccRCC, especially in females.</abstract><cop>Turkey</cop><pub>Scientific and Technological Research Council of Turkey (TUBITAK)</pub><pmid>39295621</pmid><doi>10.55730/1300-0144.5850</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-7544-9430</orcidid><orcidid>https://orcid.org/0000-0002-6765-6552</orcidid><orcidid>https://orcid.org/0000-0001-6999-5745</orcidid><orcidid>https://orcid.org/0000-0002-5322-2972</orcidid><orcidid>https://orcid.org/0000-0002-6272-6929</orcidid><orcidid>https://orcid.org/0000-0001-7175-713X</orcidid><orcidid>https://orcid.org/0000-0001-6033-7500</orcidid><orcidid>https://orcid.org/0000-0002-7637-133X</orcidid><orcidid>https://orcid.org/0000-0003-0859-1741</orcidid><oa>free_for_read</oa></addata></record>
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subjects	Abdominal Fat - diagnostic imaging Abdominal Fat - pathology Adult Aged Body Mass Index Carcinoma, Renal Cell - diagnostic imaging Carcinoma, Renal Cell - pathology Female Humans Intra-Abdominal Fat - diagnostic imaging Intra-Abdominal Fat - pathology Kidney Neoplasms - diagnostic imaging Kidney Neoplasms - pathology Male Middle Aged Neoplasm Grading Retrospective Studies Sex Factors Tomography, X-Ray Computed
title	Effect of sex-specific abdominal fat tissue composition on WHO/ISUP nuclear grade of clear cell renal cell carcinoma
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