Dysregulated FOXO1 activity drives skeletal muscle intrinsic dysfunction in amyotrophic lateral sclerosis

Amyotrophic Lateral Sclerosis (ALS) is a multisystemic neurodegenerative disorder, with accumulating evidence indicating metabolic disruptions in the skeletal muscle preceding disease symptoms, rather than them manifesting as a secondary consequence of motor neuron (MN) degeneration. Hence, energy h...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Acta neuropathologica 2024-09, Vol.148 (1), p.43, Article 43
Hauptverfasser:	Zufiría, Mónica, Pikatza-Menoio, Oihane, Garciandia-Arcelus, Maddi, Bengoetxea, Xabier, Jiménez, Andrés, Elicegui, Amaia, Levchuk, María, Arnold-García, Olatz, Ondaro, Jon, Iruzubieta, Pablo, Rodríguez-Gómez, Laura, Fernández-Pelayo, Uxoa, Muñoz-Oreja, Mikel, Aiastui, Ana, García-Verdugo, José Manuel, Herranz-Pérez, Vicente, Zulaica, Miren, Poza, Juan José, Ruiz-Onandi, Rebeca, Fernández-Torrón, Roberto, Espinal, Juan Bautista, Bonilla, Mario, Lersundi, Ana, Fernández-Eulate, Gorka, Riancho, Javier, Vallejo-Illarramendi, Ainara, Holt, Ian James, Sáenz, Amets, Malfatti, Edoardo, Duguez, Stéphanie, Blázquez, Lorea, López de Munain, Adolfo, Gerenu, Gorka, Gil-Bea, Francisco, Alonso-Martín, Sonia
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis - genetics Amyotrophic Lateral Sclerosis - metabolism Amyotrophic Lateral Sclerosis - pathology Animals Cell lines DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Drosophila Energy balance Female Forkhead Box Protein O1 - genetics Forkhead Box Protein O1 - metabolism Forkhead protein FOXO1 protein FUS gene Gene expression Homeostasis Humans Innervation Life span Male Medicine Medicine & Public Health Metabolism Middle Aged Motor Neurons - metabolism Motor Neurons - pathology Muscle Development - physiology Muscle, Skeletal - metabolism Muscle, Skeletal - pathology Musculoskeletal system Myoblasts Myoblasts - metabolism Myogenesis Nerve endings Neurodegeneration Neurodegenerative diseases Neuromuscular junctions Neurosciences Original Paper Pathology Phenotypes RNA-Binding Protein FUS - genetics RNA-Binding Protein FUS - metabolism Skeletal muscle Synapses Therapeutic targets
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!