AI-based IsAb2.0 for antibody design

Abstract Therapeutic antibody design has garnered widespread attention, highlighting its interdisciplinary importance. Advancements in technology emphasize the critical role of designing nanobodies and humanized antibodies in antibody engineering. However, current experimental methods are costly and...

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Veröffentlicht in:	Briefings in bioinformatics 2024-07, Vol.25 (5)
Hauptverfasser:	Liang, Tianjian, Sun, Ze-Yu, Hines, Margaret G, Penrose, Kerri Jo, Hao, Yixuan, Chu, Xiaojie, Mellors, John W, Dimitrov, Dimiter S, Xie, Xiang-Qun, Li, Wei, Feng, Zhiwei
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Artificial Intelligence Binding Computer Simulation Design Design standards Drug Design Experimental methods Glycoprotein gp120 HIV Envelope Protein gp120 - chemistry HIV Envelope Protein gp120 - immunology Humans Immunotherapy Nanobodies Neutralization Optimization Predictions Problem Solving Protocol Protein Engineering - methods Single-Domain Antibodies - chemistry Single-Domain Antibodies - genetics
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