Temporal epigenome modulation enables efficient bacteriophage engineering and functional analysis of phage DNA modifications

Lytic bacteriophages hold substantial promise in medical and biotechnological applications. Therefore a comprehensive understanding of phage infection mechanisms is crucial. CRISPR-Cas systems offer a way to explore these mechanisms via site-specific phage mutagenesis. However, phages can resist Cas...

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Veröffentlicht in:	PLoS genetics 2024-09, Vol.20 (9), p.e1011384
Hauptverfasser:	Pozhydaieva, Nadiia, Billau, Franziska Anna, Wolfram-Schauerte, Maik, Ramírez Rojas, Adán Andrés, Paczia, Nicole, Schindler, Daniel, Höfer, Katharina
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Bacteriophage T4 - genetics Bacteriophages Bacteriophages - genetics Biology and Life Sciences CRISPR-Cas Systems DNA DNA, Viral - genetics Engineering and Technology Enzymes Epigenome Escherichia coli - genetics Escherichia coli - virology Gene mutations Genetic aspects Genetic Engineering - methods Genome, Viral Genomes Health aspects Identification and classification Infection Medical research Medicine and Health Sciences Medicine, Experimental Mutagenesis, Site-Directed - methods Research and Analysis Methods
Online-Zugang:	Volltext
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