Equine pregnancy-specific glycoprotein CEACAM49 secreted by endometrial cup cells activates TGFB

In early equine pregnancy, a highly invasive trophoblast cell subpopulation, the chorionic girdle cells, invade the endometrium and form endometrial cups (EC). These cells express classical MHC molecules, thereby stimulating a humoral and cellular immune response, resulting in a massive accumulation...

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Veröffentlicht in:	Reproduction (Cambridge, England) England), 2020-11, Vol.160 (5), p.685-694
Hauptverfasser:	Kammerer, Robert, Ballesteros, Angela, Bonsor, Daniel, Warren, James, Williams, John M, Moore, Tom, Dveksler, Gabriela
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carcinoembryonic Antigen - metabolism Endometrium - immunology Endometrium - metabolism Endometrium - pathology Female Glycoproteins - metabolism Horses Pregnancy T-Lymphocytes, Regulatory - immunology Transforming Growth Factor beta1 - genetics Transforming Growth Factor beta1 - metabolism Trophoblasts - immunology Trophoblasts - metabolism Trophoblasts - pathology
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