Fexinidazole optimization: enhancing anti-leishmanial profile, metabolic stability and hERG safety

The lack of adequate anti-leishmanial therapies has led to the continued suffering of millions of people from developing nations. Moreover, optimism for a therapeutic intervention by fexinidazole was dashed due to the inability to maintain cures and control unwanted side effects. To solve these shor...

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Veröffentlicht in:	MedChemComm 2024-11, Vol.15 (11), p.3837-3852
Hauptverfasser:	Surur, Abdrrahman Shemsu, Chan, Chin Fung, Bartz, Frieda-Marie, Wong, Iris L. K, Nguyen, Van T. D, Schulig, Lukas, Link, Andreas, Chan, Tak Hang, Chow, Larry M. C, Bednarski, Patrick J
Format:	Artikel
Sprache:	eng
Schlagworte:	Amastigotes Chemistry Cyano groups Developing countries LDCs Metabolism Miltefosine Receptors Side effects Structural members Structural stability
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