Condensation of RNase L promotes its rapid activation in response to viral infection in mammalian cells

Oligoadenylate synthetase 3 (OAS3) and ribonuclease L (RNase L) are components of a pathway that combats viral infection in mammals. Upon detection of viral double-stranded RNA (dsRNA), OAS3 synthesizes 2'-5'-oligo(A), which activates the RNase domain of RNase L by promoting the homodimeri...

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Veröffentlicht in:	Science signaling 2024-05, Vol.17 (837), p.eadi9844-eadi9844
Hauptverfasser:	Cusic, Renee, Burke, James M
Format:	Artikel
Sprache:	eng
Schlagworte:	2',5'-Oligoadenylate Synthetase - chemistry 2',5'-Oligoadenylate Synthetase - genetics 2',5'-Oligoadenylate Synthetase - metabolism Animals Cell activation Degradation Dengue Virus - metabolism Double-stranded RNA Endoribonucleases - chemistry Endoribonucleases - genetics Endoribonucleases - metabolism Enzyme Activation Granular materials HEK293 Cells HeLa Cells Humans Mammalian cells Mammals mRNA Ribonuclease L RNA Stability RNA viruses RNA, Double-Stranded - chemistry RNA, Double-Stranded - genetics RNA, Double-Stranded - metabolism RNA, Viral - genetics RNA, Viral - metabolism Vector-borne diseases West Nile virus West Nile virus - genetics West Nile virus - metabolism Zika Virus - metabolism Zika Virus Infection - metabolism Zika Virus Infection - virology
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